Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

por Wang, Zongqiang, Forelli, Nicholas, Hernandez, Yozen, Ternei, Melinda, Brady, Sean F.
Publicado 2022

The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

por Biggins, John B., Kang, Hahk-Soo, Ternei, Melinda A., DeShazer, David, Brady, Sean F.
Publicado 2014

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

por Vila-Farres, Xavier, Chu, John, Ternei, Melinda A., Lemetre, Christophe, Park, Steven, Perlin, David S., Brady, Sean F.
Publicado 2018

Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens

por Li, Lei, Koirala, Bimal, Hernandez, Yozen, MacIntyre, Logan W., Ternei, Melinda A., Russo, Riccardo, Brady, Sean F.
Publicado 2021

Multiplexed mobilization and expression of biosynthetic gene clusters

por Libis, Vincent, MacIntyre, Logan W., Mehmood, Rabia, Guerrero, Liliana, Ternei, Melinda A., Antonovsky, Niv, Burian, Ján, Wang, Zongqiang, Brady, Sean F.
Publicado 2022

Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences

por Libis, Vincent, Antonovsky, Niv, Zhang, Mengyin, Shang, Zhuo, Montiel, Daniel, Maniko, Jeffrey, Ternei, Melinda A., Calle, Paula Y., Lemetre, Christophe, Owen, Jeremy G., Brady, Sean F.
Publicado 2019

Global biogeographic sampling of bacterial secondary metabolism

por Charlop-Powers, Zachary, Owen, Jeremy G, Reddy, Boojala Vijay B, Ternei, Melinda A, Guimarães, Denise O, de Frias, Ulysses A, Pupo, Monica T, Seepe, Prudy, Feng, Zhiyang, Brady, Sean F
Publicado 2015

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

por Hover, Bradley M., Kim, Seong-Hwan, Katz, Micah, Charlop-Powers, Zachary, Owen, Jeremy G., Ternei, Melinda A., Maniko, Jeffrey, Estrela, Andreia, Molina, Henrik, Park, Steven, Perlin, David S., Brady, Sean F.
Publicado 2018

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

por Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Ternei, Melinda, Cohen, Louis J., Gordon, Emma A., Reddy, Boojala Vijay B., Charlop-Powers, Zachary, Zebroski, Henry A., Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Park, Steven, Perlin, David S., Freundlich, Joel S., Brady, Sean F.
Publicado 2016

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

por Peek, James, Lilic, Mirjana, Montiel, Daniel, Milshteyn, Aleksandr, Woodworth, Ian, Biggins, John B., Ternei, Melinda A., Calle, Paula Y., Danziger, Michael, Warrier, Thulasi, Saito, Kohta, Braffman, Nathaniel, Fay, Allison, Glickman, Michael S., Darst, Seth A., Campbell, Elizabeth A., Brady, Sean F.
Publicado 2018