Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca(2+)

por Terrar, Derek A.
Publicado 2023

Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node

por Capel, Rebecca A., Terrar, Derek A.
Publicado 2015

The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat

por Capel, Rebecca A., Terrar, Derek A.
Publicado 2015

Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP(3)-Evoked Calcium Release Stimulates Adenylyl Cyclases

por Burton, Rebecca-Ann B., Terrar, Derek A.
Publicado 2021

Contributions of cardiac “funny” (f) channels and sarcoplasmic reticulum Ca(2+) in regulating beating rate of mouse and guinea pig sinoatrial node

por Nazarov, Islom B., Schofield, Christopher J., Terrar, Derek A.
Publicado 2015

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

por Fan, Xuehui, Sun, Tianyi, Crawford, William, Tan, Xiaoqiu, Ou, Xianhong, Terrar, Derek A., Ebert, Steven N., Lei, Ming
Publicado 2019

Cardiac electrophysiological imaging systems scalable for high-throughput drug testing

por Lee, Peter, Wang, Ken, Woods, Christopher E., Yan, Ping, Kohl, Peter, Ewart, Paul, Loew, Leslie M., Terrar, Derek A., Bollensdorff, Christian
Publicado 2012

IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases

por Capel, Rebecca A., Bose, Samuel J., Collins, Thomas P., Rajasundaram, Skanda, Ayagama, Thamali, Zaccolo, Manuela, Burton, Rebecca-Ann Beatrice, Terrar, Derek A.
Publicado 2021

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP(3)-evoked changes in sino-atrial node beat rate

por Bose, Samuel J., Read, Matthew J., Akerman, Emily, Capel, Rebecca A., Ayagama, Thamali, Russell, Angela, Terrar, Derek A., Zaccolo, Manuela, Burton, Rebecca A. B.
Publicado 2022

Inhibition of Angiotensin II-Induced Cardiac Hypertrophy and Associated Ventricular Arrhythmias by a p21 Activated Kinase 1 Bioactive Peptide

por Wang, Rui, Wang, Yanwen, Lin, Wee K., Zhang, Yanmin, Liu, Wei, Huang, Kai, Terrar, Derek A., Solaro, R. John, Wang, Xin, Ke, Yunbo, Lei, Ming
Publicado 2014

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I(f): Novel electrophysiological insights and therapeutic potential

por Capel, Rebecca A., Herring, Neil, Kalla, Manish, Yavari, Arash, Mirams, Gary R., Douglas, Gillian, Bub, Gil, Channon, Keith, Paterson, David J., Terrar, Derek A., Burton, Rebecca-Ann B.
Publicado 2015

Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca(2+) transients in murine heart

por Wen, Q., Gandhi, K., Capel, Rebecca A., Hao, G., O'Shea, C., Neagu, G., Pearcey, S., Pavlovic, D., Terrar, Derek A., Wu, J., Faggian, G., Camelliti, Patrizia, Lei, M.
Publicado 2018

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

por Aston, Daniel, Capel, Rebecca A., Ford, Kerrie L., Christian, Helen C., Mirams, Gary R., Rog-Zielinska, Eva A., Kohl, Peter, Galione, Antony, Burton, Rebecca A. B., Terrar, Derek A.
Publicado 2017

Synthesis of the Ca(2+)-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

por Lin, Wee K., Bolton, Emma L., Cortopassi, Wilian A., Wang, Yanwen, O'Brien, Fiona, Maciejewska, Matylda, Jacobson, Matthew P., Garnham, Clive, Ruas, Margarida, Parrington, John, Lei, Ming, Sitsapesan, Rebecca, Galione, Antony, Terrar, Derek A.
Publicado 2017

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt(+) Cells in Murine Heart

por Wang, Yanwen, Lin, Wee Khang, Crawford, William, Ni, Haibo, Bolton, Emma L., Khan, Huma, Shanks, Julia, Bub, Gil, Wang, Xin, Paterson, David J., Zhang, Henggui, Galione, Antony, Ebert, Steven N., Terrar, Derek A., Lei, Ming
Publicado 2017

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Sig...

por Capel, Rebecca A., Bolton, Emma L., Lin, Wee K., Aston, Daniel, Wang, Yanwen, Liu, Wei, Wang, Xin, Burton, Rebecca-Ann B., Bloor-Young, Duncan, Shade, Kai-Ting, Ruas, Margarida, Parrington, John, Churchill, Grant C., Lei, Ming, Galione, Antony, Terrar, Derek A.
Publicado 2015

Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists

por Ahmad, Faizzan S., Jin, Yongcheng, Grassam-Rowe, Alexander, Zhou, Yafei, Yuan, Meng, Fan, Xuehui, Zhou, Rui, Mu-u-min, Razik, O'Shea, Christopher, Ibrahim, Ayman M., Hyder, Wajiha, Aguib, Yasmine, Yacoub, Magdi, Pavlovic, Davor, Zhang, Yanmin, Tan, Xiaoqiu, Lei, Ming, Terrar, Derek A.
Publicado 2023