Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa

por Heitmeier, Stefan, Visser, Mayken, Tersteegen, Adrian, Dietze‐Torres, Julia, Glunz, Julia, Gerdes, Christoph, Laux, Volker, Stampfuss, Jan, Roehrig, Susanne
Publicado 2022

Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders

por Roehrig, Susanne, Ackerstaff, Jens, Jiménez Núñez, Eloísa, Teller, Henrik, Ellerbrock, Pascal, Meier, Katharina, Heitmeier, Stefan, Tersteegen, Adrian, Stampfuss, Jan, Lang, Dieter, Schlemmer, Karl-Heinz, Schaefer, Martina, Gericke, Kersten M., Kinzel, Tom, Meibom, Daniel, Schmidt, Martina, Gerdes, Christoph, Follmann, Markus, Hillisch, Alexander
Publicado 2023

BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor

por Meibom, Daniel, Micus, Sina, Andreevski, Anna Lena, Anlauf, Sonja, Bogner, Pamela, von Buehler, Clemens-Jeremias, Dieskau, André P., Dreher, Jan, Eitner, Frank, Fliegner, Daniela, Follmann, Markus, Gericke, Kersten Matthias, Maassen, Stefanie, Meyer, Jutta, Schlemmer, Karl-Heinz, Steuber, Holger, Tersteegen, Adrian, Wunder, Frank
Publicado 2022

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

por von Nussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian
Publicado 2015

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

por Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi
Publicado 2021