Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

por Homan, Kristoff T., Tesmer, John J. G.
Publicado 2014

G protein–coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias

por Chen, Qiuyan, Tesmer, John J.G.
Publicado 2022

Membrane Orientation and Binding Determinants of G Protein-Coupled Receptor Kinase 5 as Assessed by Combined Vibrational Spectroscopic Studies

por Yang, Pei, Glukhova, Alisa, Tesmer, John J. G., Chen, Zhan
Publicado 2013

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP(3)

por Cash, Jennifer N., Sharma, Prateek V., Tesmer, John J.G.
Publicado 2018

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

por Thapaliya, Monica, Amponnawarat, Aetas, Tesmer, John J. G., Ali, Hydar
Publicado 2022

Atypical Chemokine Receptor 3 ‘Senses’ CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

por Schafer, Christopher T., Chen, Qiuyan, Tesmer, John J. G., Handel, Tracy M.
Publicado 2023

Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

por Homan, Kristoff T., Wu, Emily, Cannavo, Alessandro, Koch, Walter J., Tesmer, John J. G.
Publicado 2014

Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain

por Lyon, Angeline M., Dutta, Somnath, Boguth, Cassandra A., Skiniotis, Georgios, Tesmer, John J. G.
Publicado 2013

Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

por Ding, Bei, Glukhova, Alisa, Sobczyk-Kojiro, Katarzyna, Mosberg, Henry I., Tesmer, John J. G., Chen, Zhan
Publicado 2014

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

por Homan, Kristoff T., Larimore, Kelly M., Elkins, Jonathan M., Szklarz, Marta, Knapp, Stefan, Tesmer, John J. G.
Publicado 2014

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ

por Chen, Chun-Liang, Syahirah, Ramizah, Ravala, Sandeep K., Yen, Yu-Chen, Klose, Thomas, Deng, Qing, Tesmer, John J. G.
Publicado 2023

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis

por Hinkovska-Galcheva, Vania, Treadwell, Taylour, Shillingford, Jonathan M., Lee, Angela, Abe, Akira, Tesmer, John J.G., Shayman, James A.
Publicado 2021

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

por Yen, Yu-Chen, Li, Yong, Chen, Chun-Liang, Klose, Thomas, Watts, Val J, Dessauer, Carmen W, Tesmer, John J. G.
Publicado 2023

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

por Inagaki, Sayaka, Ghirlando, Rodolfo, Vishnivetskiy, Sergey A., Homan, Kristoff T., White, Jim F., Tesmer, John J. G., Gurevich, Vsevolod V., Grisshammer, Reinhard
Publicado 2015

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

por Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Publicado 2018

A Global Map of G Protein Signaling Regulation by RGS Proteins

por Masuho, Ikuo, Balaji, Santhanam, Muntean, Brian S., Skamangas, Nickolas K., Chavali, Sreenivas, Tesmer, John J.G., Babu, M. Madan, Martemyanov, Kirill A.
Publicado 2020

The Open Question of How GPCRs Interact with GPCR Kinases (GRKs)

por Cato, M. Claire, Yen, Yu-Chen, Francis, Charnelle J., Elkins, Kaely E., Shareef, Afzaal, Sterne-Marr, Rachel, Tesmer, John J. G.
Publicado 2021

ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

por Chen, Qiuyan, Schafer, Christopher T., Mukherjee, Somnath, Gustavsson, Martin, Agrawal, Parth, Yao, Xin-Qiu, Kossiakoff, Anthony A., Handel, Tracy M., Tesmer, John J. G.
Publicado 2023

Biochemical characterization of the interaction between KRAS and Argonaute 2

por Waninger, Jessica J., Beyett, Tyler S., Gadkari, Varun V., Siebenaler, Ronald F., Kenum, Carson, Shankar, Sunita, Ruotolo, Brandon T., Chinnaiyan, Arul M., Tesmer, John J.G.
Publicado 2021

Structural and dynamic changes in P-Rex1 upon activation by PIP(3) and inhibition by IP(4)

por Ravala, Sandeep K., Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A., Gutkind, J. Silvio, Cash, Jennifer N., Tesmer, John J. G.
Publicado 2023