Lifting the veil on amyloid drug design

por Tiller, Kathryn E, Tessier, Peter M
Publicado 2013

Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis

por Zupancic, Jennifer M., Desai, Alec A., Tessier, Peter M.
Publicado 2022

Toward Drug-Like Multispecific Antibodies by Design

por Sawant, Manali S., Streu, Craig N., Wu, Lina, Tessier, Peter M.
Publicado 2020

Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods

por Makowski, Emily K., Wu, Lina, Gupta, Priyanka, Tessier, Peter M.
Publicado 2021

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

por Makowski, Emily K., Wu, Lina, Desai, Alec A., Tessier, Peter M.
Publicado 2021

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape

por Makowski, Emily K., Schardt, John S., Smith, Matthew D., Tessier, Peter M.
Publicado 2022

Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data

por Smith, Matthew D, Case, Marshall A, Makowski, Emily K, Tessier, Peter M
Publicado 2023

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

por Julian, Mark C., Li, Lijuan, Garde, Shekhar, Wilen, Rebecca, Tessier, Peter M.
Publicado 2017

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

por Limbocker, Ryan, Cremades, Nunilo, Cascella, Roberta, Tessier, Peter M., Vendruscolo, Michele, Chiti, Fabrizio
Publicado 2023

Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

por Tiller, Kathryn E., Chowdhury, Ratul, Li, Tong, Ludwig, Seth D., Sen, Sabyasachi, Maranas, Costas D., Tessier, Peter M.
Publicado 2017

A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain

por Pornnoppadol, Ghasidit, Zhang, Boya, Desai, Alec A., Berardi, Anthony, Remmer, Henriette A., Tessier, Peter M., Greineder, Colin F.
Publicado 2021

An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies

por Estep, Patricia, Caffry, Isabelle, Yu, Yao, Sun, Tingwan, Cao, Yuan, Lynaugh, Heather, Jain, Tushar, Vásquez, Maximiliano, Tessier, Peter M, Xu, Yingda
Publicado 2015

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

por Zupancic, Jennifer M., Smith, Matthew D., Trzeciakiewicz, Hanna, Skinner, Mary E., Ferris, Sean P., Makowski, Emily K., Lucas, Michael J., McArthur, Nikki, Kane, Ravi S., Paulson, Henry L., Tessier, Peter M.
Publicado 2023

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

por Makowski, Emily K., Kinnunen, Patrick C., Huang, Jie, Wu, Lina, Smith, Matthew D., Wang, Tiexin, Desai, Alec A., Streu, Craig N., Zhang, Yulei, Zupancic, Jennifer M., Schardt, John S., Linderman, Jennifer J., Tessier, Peter M.
Publicado 2022

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

por Zupancic, Jennifer M., Desai, Alec A., Schardt, John S., Pornnoppadol, Ghasidit, Makowski, Emily K., Smith, Matthew D., Kennedy, Andrew A., Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Tai, Andrew W., Tessier, Peter M.
Publicado 2021

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

por Schardt, John S., Pornnoppadol, Ghasidit, Desai, Alec A., Park, Kyung Soo, Zupancic, Jennifer M., Makowski, Emily K., Smith, Matthew D., Chen, Hongwei, Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Moon, James J., Tessier, Peter M.
Publicado 2021

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

por Makowski, Emily K., Chen, Hongwei, Lambert, Matthew, Bennett, Eric M., Eschmann, Nicole S., Zhang, Yulei, Zupancic, Jennifer M., Desai, Alec A., Smith, Matthew D., Lou, Wenjia, Fernando, Amendra, Tully, Timothy, Gallo, Christopher J., Lin, Laura, Tessier, Peter M.
Publicado 2022

Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

por Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
Publicado 2021

Assessing developability early in the discovery process for novel biologics

por Fernández-Quintero, Monica L., Ljungars, Anne, Waibl, Franz, Greiff, Victor, Andersen, Jan Terje, Gjølberg, Torleif T., Jenkins, Timothy P., Voldborg, Bjørn Gunnar, Grav, Lise Marie, Kumar, Sandeep, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R., Tessier, Peter M., McCafferty, John, Laustsen, Andreas H.
Publicado 2023

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

por Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George
Publicado 2019