Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny

por Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven
Publicado 2023

Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs

por Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B.
Publicado 2016

Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia

por Sewing, Sabine, Roth, Adrian B., Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C., Singer, Thomas, Rothfuss, Andreas
Publicado 2017

Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

por Valenzuela, Allan, Tardiveau, Claire, Ayuso, Miriam, Buyssens, Laura, Bars, Chloe, Van Ginneken, Chris, Fant, Pierluigi, Leconte, Isabelle, Braendli-Baiocco, Annamaria, Parrott, Neil, Schmitt, Georg, Tessier, Yann, Barrow, Paul, Van Cruchten, Steven
Publicado 2021

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling

por Moisan, Annie, Gubler, Marcel, Zhang, Jitao David, Tessier, Yann, Dumong Erichsen, Kamille, Sewing, Sabine, Gérard, Régine, Avignon, Blandine, Huber, Sylwia, Benmansour, Fethallah, Chen, Xing, Villaseñor, Roberto, Braendli-Baiocco, Annamaria, Festag, Matthias, Maunz, Andreas, Singer, Thomas, Schuler, Franz, Roth, Adrian B.
Publicado 2017

From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides

por Braendli-Baiocco, Annamaria, Festag, Matthias, Dumong Erichsen, Kamille, Persson, Robert, Mihatsch, Michael J., Fisker, Niels, Funk, Juergen, Mohr, Susanne, Constien, Rainer, Ploix, Corinne, Brady, Kevin, Berrera, Marco, Altmann, Bernd, Lenz, Barbara, Albassam, Mudher, Schmitt, Georg, Weiser, Thomas, Schuler, Franz, Singer, Thomas, Tessier, Yann
Publicado 2017