Synthesis, Characterization, and Antibacterial Studies of Mixed Ligand Dioxouranium Complexes with 8-Hydroxyquinoline and Some Amino Acids

por Patil, Sunil S., Thakur, Ganesh A., Shaikh, Manzoor M.
Publicado 2011

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

por Gazgalis, Dimitrios, Cantwell, Lucas, Xu, Yu, Thakur, Ganesh A., Cui, Meng, Guarnieri, Frank, Logothetis, Diomedes E.
Publicado 2022

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB(2) receptor activation and independent of CXCR4 signaling in mode...

por Deng, Liting, Guindon, Josée, Vemuri, V Kiran, Thakur, Ganesh A, White, Fletcher A, Makriyannis, Alexandros, Hohmann, Andrea G
Publicado 2012

Positive Allosteric Modulation of CB(1) Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Depen...

por Slivicki, Richard A., Iyer, Vishakh, Mali, Sonali S., Garai, Sumanta, Thakur, Ganesh A., Crystal, Jonathon D., Hohmann, Andrea G.
Publicado 2020

GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating m...

por Gauthier, Alex G., Lin, Mosi, Zefi, Sidorela, Kulkarni, Abhijit, Thakur, Ganesh A., Ashby, Charles R., Mantell, Lin L.
Publicado 2023

PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction

por Gardner, Eliot L., Bi, Guo-Hua, Thakur, Ganesh, Makriyannis, Alexandros, Seltzman, Herbert H., He, Xiang-Hu, Xi, Zheng-Xiong
Publicado 2016

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

por Mizrachi, Tehila, Marsha, Oshrit, Brusin, Karen, Ben-David, Yael, Thakur, Ganesh A., Vaknin-Dembinsky, Adi, Treinin, Millet, Brenner, Talma
Publicado 2021

Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors

por Fichna, Jakub, Bawa, Misha, Thakur, Ganesh A., Tichkule, Ritesh, Makriyannis, Alexandros, McCafferty, Donna-Marie, Sharkey, Keith A., Storr, Martin
Publicado 2014

Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

por Wilkerson, Jenny L., Alberti, Lauren B., Kerwin, Audra A., Ledent, Catherine A., Thakur, Ganesh A., Makriyannis, Alexandros, Milligan, Erin D.
Publicado 2020

Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery

por Rahn, Elizabeth J, Deng, Liting, Thakur, Ganesh A, Vemuri, Kiran, Zvonok, Alexander M, Lai, Yvonne Y, Makriyannis, Alexandros, Hohmann, Andrea G
Publicado 2014

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

por Thapa, Dinesh, Cairns, Elizabeth A., Szczesniak, Anna-Maria, Kulkarni, Pushkar M., Straiker, Alex J., Thakur, Ganesh A., Kelly, Melanie E. M.
Publicado 2020

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

por Laprairie, Robert B., Mohamed, Kawthar A., Zagzoog, Ayat, Kelly, Melanie E. M., Stevenson, Lesley A., Pertwee, Roger, Denovan-Wright, Eileen M., Thakur, Ganesh A.
Publicado 2019

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study...

por Brems, Brittany M., Sullivan, Erin E., Connolly, Jenna G., Zhang, Jingchun, Chang, Arnold, Ortiz, Richard, Cantwell, Lucas, Kulkarni, Praveen, Thakur, Ganesh A., Ferris, Craig F.
Publicado 2023

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrop...

por Gauthier, Alex G., Wu, Jiaqi, Lin, Mosi, Sitapara, Ravikumar, Kulkarni, Abhijit, Thakur, Ganesh A., Schmidt, Edward E., Perron, Jeanette C., Ashby, Charles R., Mantell, Lin L.
Publicado 2021

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

por Brandt, Asher L., Garai, Sumanta, Zagzoog, Ayat, Hurst, Dow P., Stevenson, Lesley A., Pertwee, Roger G., Imler, Gregory H., Reggio, Patricia H., Thakur, Ganesh A., Laprairie, Robert B.
Publicado 2022

Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief...

por Wilkerson, Jenny L, Gentry, Katherine R, Dengler, Ellen C, Wallace, James A, Kerwin, Audra A, Kuhn, Megan N, Zvonok, Alexander M, Thakur, Ganesh A, Makriyannis, Alexandros, Milligan, Erin D
Publicado 2012

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

por McElroy, Dan L., Roebuck, Andrew J., Greba, Quentin, Garai, Sumanta, Brandt, Asher L., Yilmaz, Orhan, Cain, Stuart M., Snutch, Terrance P., Thakur, Ganesh A., Laprairie, Robert B., Howland, John G.
Publicado 2022

Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats

por Oliva, Idaira, Saberi, Shahin A., Rangel‐Barajas, Claudia, Iyer, Vishakh, Bunner, Kendra D., Lai, Yvonne Y., Kulkarni, Pushkar M., Garai, Sumanta, Thakur, Ganesh A., Crystal, Jonathon D., Rebec, George V., Hohmann, Andrea G.
Publicado 2022

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

por Kulkarni, Pushkar M., Kulkarni, Abhijit R., Korde, Anisha, Tichkule, Ritesh B., Laprairie, Robert B., Denovan-Wright, Eileen M., Zhou, Han, Janero, David R., Zvonok, Nikolai, Makriyannis, Alexandros, Cascio, Maria G., Pertwee, Roger G., Thakur, Ganesh A.
Publicado 2015