Lysine specific demethylase 1 is a molecular driver and therapeutic target in sarcoma

por Dreher, Rachel D., Theisen, Emily R.
Publicado 2023

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting

por Theisen, Emily R., Pishas, Kathleen I., Saund, Ranajeet S., Lessnick, Stephen L.
Publicado 2016

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma

por Theisen, Emily R, Gajiwala, Snehal, Bearss, Jared, Sorna, Venkataswamy, Sharma, Sunil, Janat-Amsbury, Margit
Publicado 2014

Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis

por Theisen, Emily R., Miller, Kyle R., Showpnil, Iftekhar A., Taslim, Cenny, Pishas, Kathleen I., Lessnick, Stephen L.
Publicado 2019

Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma

por Patel, Priyal O., Pishas, Kathleen I., Taslim, Cenny, Selich-Anderson, Julia, Theisen, Emily R., Lessnick, Stephen L.
Publicado 2019

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma

por Showpnil, Iftekhar A, Selich-Anderson, Julia, Taslim, Cenny, Boone, Megann A, Crow, Jesse C, Theisen, Emily R, Lessnick, Stephen L
Publicado 2022

Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein

por Theisen, Emily R., Selich-Anderson, Julia, Miller, Kyle R., Tanner, Jason M., Taslim, Cenny, Pishas, Kathleen I., Sharma, Sunil, Lessnick, Stephen L.
Publicado 2020

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

por Boone, Megann A., Taslim, Cenny, Crow, Jesse C., Selich-Anderson, Julia, Byrum, Andrea K., Showpnil, Iftekhar A., Sunkel, Benjamin D., Wang, Meng, Stanton, Benjamin Z., Theisen, Emily R., Lessnick, Stephen L.
Publicado 2021

Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma

por Tokarsky, E. John, Crow, Jesse C., Guenther, Lillian M., Sherman, John, Taslim, Cenny, Alexe, Gabriela, Pishas, Kathleen I., Rask, Galen, Justis, Blake S., Kasumova, Ana, Stegmaier, Kimberly, Lessnick, Stephen L., Theisen, Emily R.
Publicado 2022