Netupitant and palonosetron trigger NK(1) receptor internalization in NG108-15 cells

por Thomas, Ajit G., Stathis, Marigo, Rojas, Camilo, Slusher, Barbara S.
Publicado 2014

Development of a primary microglia screening assay and its use to characterize inhibition of system x(c)(-) by erastin and its analogs

por Figuera-Losada, Mariana, Thomas, Ajit G., Stathis, Marigo, Stockwell, Brent R., Rojas, Camilo, Slusher, Barbara S.
Publicado 2017

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

por Thomas, Ajit G., Sattler, Rita, Tendyke, Karen, Loiacono, Kara A., Hansen, Hans, Sahni, Vishal, Hashizume, Yutaka, Rojas, Camilo, Slusher, Barbara S.
Publicado 2015

An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity

por Hossain, Md Imran, Thomas, Ajit G., Mahdi, Fakhri, Adam, Amna T., Akins, Nicholas S., Woodard, Morgan M., Paris, Jason J., Slusher, Barbara S., Le, Hoang V.
Publicado 2021

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d-Amino Acid Oxidase Inhibitors

por Hin, Niyada, Duvall, Bridget, Ferraris, Dana, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Rojas, Camilo, Wu, Ying, Wozniak, Krystyna M., Slusher, Barbara S., Tsukamoto, Takashi
Publicado 2015

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

por Zimmermann, Sarah C., Wolf, Emily F., Luu, Andrew, Thomas, Ajit G., Stathis, Marigo, Poore, Brad, Nguyen, Christopher, Le, Anne, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Publicado 2016

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

por Gori, Sadakatali S., Thomas, Ajit G., Pal, Arindom, Wiseman, Robyn, Ferraris, Dana V., Gao, Run-duo, Wu, Ying, Alt, Jesse, Tsukamoto, Takashi, Slusher, Barbara S., Rais, Rana
Publicado 2022

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

por Lee, Kyungho, Thompson, Elizabeth A., Gharaie, Sepideh, Patel, Chirag H., Kurzhagen, Johanna T., Pierorazio, Phillip M., Arend, Lois J., Thomas, Ajit G., Noel, Sanjeev, Slusher, Barbara S., Rabb, Hamid
Publicado 2023

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

por Dixon, Scott J, Patel, Darpan N, Welsch, Matthew, Skouta, Rachid, Lee, Eric D, Hayano, Miki, Thomas, Ajit G, Gleason, Caroline E, Tatonetti, Nicholas P, Slusher, Barbara S, Stockwell, Brent R
Publicado 2014

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

por Khoury, Elizabeth Smith, Sharma, Anjali, Ramireddy, Rajasekhar R, Thomas, Ajit G., Alt, Jesse, Fowler, Amanda, Rais, Rana, Tsukamoto, Takashi, Blue, Mary E., Slusher, Barbara, Kannan, Sujatha, Kannan, Rangaramanujam M.
Publicado 2020

Inhibition of neutral sphingomyelinase 2 promotes remyelination

por Yoo, Seung-Wan, Agarwal, Amit, Smith, Matthew D., Khuder, Saja S., Baxi, Emily G., Thomas, Ajit G., Rojas, Camilo, Moniruzzaman, Mohammed, Slusher, Barbara S., Bergles, Dwight E., Calabresi, Peter A., Haughey, Norman J.
Publicado 2020

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

por Huang, Meixiang, Tallon, Carolyn, Zhu, Xiaolei, Huizar, Kaitlyn D. J., Picciolini, Silvia, Thomas, Ajit G., Tenora, Lukas, Liyanage, Wathsala, Rodà, Francesca, Gualerzi, Alice, Kannan, Rangaramanujam M., Bedoni, Marzia, Rais, Rana, Slusher, Barbara S.
Publicado 2023

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

por Zhu, Xiaolei, Hollinger, Kristen R., Huang, Yiyao, Borjabad, Alejandra, Kim, Boe-Hyun, Arab, Tanina, Thomas, Ajit G., Moniruzzaman, Mohammed, Lovell, Lyndah, Turchinovich, Andrey, Witwer, Kenneth W., Volsky, David J., Haughey, Norman J., Slusher, Barbara S.
Publicado 2022

Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties

por Figuera-Losada, Mariana, Stathis, Marigo, Dorskind, Joelle M., Thomas, Ajit G., Bandaru, Veera Venkata Ratnam, Yoo, Seung-Wan, Westwood, Nicholas J., Rogers, Graeme W., McArthur, Justin C., Haughey, Norman J., Slusher, Barbara S., Rojas, Camilo
Publicado 2015

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

por Hollinger, Kristen R., Sharma, Anjali, Tallon, Carolyn, Lovell, Lyndah, Thomas, Ajit G., Zhu, Xiaolei, Wiseman, Robyn, Wu, Ying, Kambhampati, Siva P., Liaw, Kevin, Sharma, Rishi, Rojas, Camilo, Rais, Rana, Kannan, Sujatha, Kannan, Rangaramanujam M., Slusher, Barbara S.
Publicado 2022

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

por Tallon, Carolyn, Bell, Benjamin J., Sharma, Anjali, Pal, Arindom, Malvankar, Medhinee M., Thomas, Ajit G., Yoo, Seung-Wan, Hollinger, Kristen R., Coleman, Kaleem, Wilkinson, Elizabeth L., Kannan, Sujatha, Haughey, Norman J., Kannan, Rangaramanujam M., Rais, Rana, Slusher, Barbara S.
Publicado 2022

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease

por Tallon, Carolyn, Bell, Benjamin J, Malvankar, Medhinee M, Deme, Pragney, Nogueras-Ortiz, Carlos, Eren, Erden, Thomas, Ajit G, Hollinger, Kristen R, Pal, Arindom, Mustapic, Maja, Huang, Meixiang, Coleman, Kaleem, Joe, Tawnjerae R, Rais, Rana, Haughey, Norman J, Kapogiannis, Dimitrios, Slusher, Barbara S
Publicado 2023

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

por Tallon, Carolyn, Bell, Benjamin J., Malvankar, Medhinee M., Deme, Pragney, Nogueras-Ortiz, Carlos, Eren, Erden, Thomas, Ajit G., Hollinger, Kristen R., Pal, Arindom, Mustapic, Maja, Huang, Meixiang, Coleman, Kaleem, Joe, Tawnjerae R., Rais, Rana, Haughey, Norman J., Kapogiannis, Dimitrios, Slusher, Barbara S.
Publicado 2023

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

por Rojas, Camilo, Barnaeva, Elena, Thomas, Ajit G., Hu, Xin, Southall, Noel, Marugan, Juan, Chaudhuri, Amrita Datta, Yoo, Seung-Wan, Hin, Niyada, Stepanek, Ondrej, Wu, Ying, Zimmermann, Sarah C., Gadiano, Alexandra G., Tsukamoto, Takashi, Rais, Rana, Haughey, Norman, Ferrer, Marc, Slusher, Barbara S.
Publicado 2018

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

por Udupa, Sunag, Nguyen, Stephanie, Hoang, Giang, Nguyen, Tu, Quinones, Addison, Pham, Khoa, Asaka, Ryoichi, Nguyen, Kiet, Zhang, Cissy, Elgogary, Amira, Jung, Jin G., Xu, Qingguo, Fu, Jie, Thomas, Ajit G., Tsukamoto, Takashi, Hanes, Justin, Slusher, Barbara S., Cooper, Arthur J. L., Le, Anne
Publicado 2019