Targeting MYC through WDR5

por Thomas, Lance R., Adams, Clare M., Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Publicado 2020

A common functional consequence of tumor-derived mutations within c-MYC

por Chakraborty, Abhishek A., Scuoppo, Claudio, Dey, Soumyadeep, Thomas, Lance R., Lorey, Shelly L., Lowe, Scott W., Tansey, William. P.
Publicado 2014

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

por Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Publicado 2019

Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue

por Jovanović, Bojana, Sheng, Quanhu, Seitz, Robert S., Lawrence, Kasey D., Morris, Stephan W., Thomas, Lance R., Hout, David R., Schweitzer, Brock L., Guo, Yan, Pietenpol, Jennifer A., Lehmann, Brian D.
Publicado 2017

Interaction of MYC with Host Cell Factor-1 is meditated by the evolutionarily-conserved Myc box IV motif

por Thomas, Lance R., Foshage, Audra M., Weissmiller, April M., Popay, Tessa M., Grieb, Brian C., Qualls, Susan J., Ng, Victoria, Carboneau, Bethany, Lorey, Shelly, Eischen, Christine M., Tansey, William P.
Publicado 2015

WIN site inhibition disrupts a subset of WDR5 function

por Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Publicado 2022

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

por Popay, Tessa M, Wang, Jing, Adams, Clare M, Howard, Gregory Caleb, Codreanu, Simona G, Sherrod, Stacy D, McLean, John A, Thomas, Lance R, Lorey, Shelly L, Machida, Yuichi J, Weissmiller, April M, Eischen, Christine M, Liu, Qi, Tansey, William P
Publicado 2021

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

por Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Publicado 2019