Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

por Hendrickson, Rebecca C., Thomas, Ronald G., Schork, Nicholas J., Raskind, Murray A.
Publicado 2020

Randomized controlled trials in mild cognitive impairment: Sources of variability

por Petersen, Ronald C., Thomas, Ronald G., Aisen, Paul S., Mohs, Richard C., Carrillo, Maria C., Albert, Marilyn S.
Publicado 2017

Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS‐Cog‐Exec

por Jacobs, Diane M., Thomas, Ronald G., Salmon, David P., Jin, Shelia, Feldman, Howard H., Cotman, Carl W., Baker, Laura D.
Publicado 2020

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease

por Gelmont, David, Thomas, Ronald G., Britt, Jonathan, Dyck-Jones, Jacqueline A., Doralt, Jennifer, Fritsch, Sandor, Brewer, James B., Rissman, Robert A., Aisen, Paul
Publicado 2016

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

por Hendrickson, Rebecca C., McCall, Catherine A., Rosser, Aaron F., Pagulayan, Kathleen F., Chang, Bernard P., Sano, Ellen D., Thomas, Ronald G., Raskind, Murray A.
Publicado 2022

The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers

por Hendrickson, Rebecca C., McCall, Catherine A., Rosser, Aaron F., Pagulayan, Kathleen F., Chang, Bernard P., Sano, Ellen D., Thomas, Ronald G., Raskind, Murray A.
Publicado 2023

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

por Turner, R. Scott, Thomas, Ronald G., Craft, Suzanne, van Dyck, Christopher H., Mintzer, Jacobo, Reynolds, Brigid A., Brewer, James B., Rissman, Robert A., Raman, Rema, Aisen, Paul S.
Publicado 2015

The Impact of the COVID-19 Pandemic on Mental Health, Occupational Functioning, and Professional Retention Among Health Care Workers and First Responders

por Hendrickson, Rebecca C., Slevin, Roisín A., Hoerster, Katherine D., Chang, Bernard P., Sano, Ellen, McCall, Catherine A., Monty, Gillian R., Thomas, Ronald G., Raskind, Murray A.
Publicado 2021

Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study

por Keil, Samantha A., Schindler, Abigail G., Wang, Marie X., Piantino, Juan, Silbert, Lisa C., Elliott, Jonathan E., Thomas, Ronald G., Willis, Sherry, Lim, Miranda M., Iliff, Jeffrey J.
Publicado 2023

Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease

por Doody, Rachelle S, Raman, Rema, Sperling, Reisa A, Seimers, Eric, Sethuraman, Gopalan, Mohs, Richard, Farlow, Martin, Iwatsubo, Takeshi, Vellas, Bruno, Sun, Xiaoying, Ernstrom, Karin, Thomas, Ronald G, Aisen, Paul S
Publicado 2015

The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease

por Langbaum, Jessica B., Ellison, Noel N., Caputo, Angelika, Thomas, Ronald G., Langlois, Carolyn, Riviere, Marie-Emmanuelle, Graf, Ana, Lopez Lopez, Cristina, Reiman, Eric M., Tariot, Pierre N., Hendrix, Suzanne B.
Publicado 2020

Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults

por Keil, Samantha A., Schindler, Abigail G., Wang, Marie X., Piantino, Juan, Silbert, Lisa C., Elliott, Jonathan E., Werhane, Madeleine L., Thomas, Ronald G., Willis, Sherry, Lim, Miranda M., Iliff, Jeffrey J.
Publicado 2023

Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia

por Matthews, Dawn C., Ritter, Aaron, Thomas, Ronald G., Andrews, Randolph D., Lukic, Ana S., Revta, Carolyn, Kinney, Jefferson W., Tousi, Babak, Leverenz, James B., Fillit, Howard, Zhong, Kate, Feldman, Howard H., Cummings, Jeffrey
Publicado 2021

Impact of potential modifications to Alzheimer’s disease clinical trials in response to disruption by COVID-19: a simulation study

por Schneider, Lon S., Qiu, Yuqi, Thomas, Ronald G., Evans, Carol, Jacobs, Diane M., Jin, Shelia, Kaye, Jeffrey A., LaCroix, Andrea Z., Messer, Karen, Salmon, David P., Sano, Mary, Schafer, Kimberly, Feldman, Howard H.
Publicado 2021

T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer's disease

por Shadyab, Aladdin H., LaCroix, Andrea Z., Matthews, Genevieve, Bennett, Daniel, Shadyab, Alexandre A., Tan, Donna, Thomas, Ronald G., Mason, Jennifer, Lopez, Alex, Askew, Brianna, Donahue, Lia, Kaplita, Stephen, Qureshi, Irfan A., Huisa, Branko, Feldman, Howard H.
Publicado 2022

The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease

por Lopez Lopez, Cristina, Tariot, Pierre N., Caputo, Angelika, Langbaum, Jessica B., Liu, Fonda, Riviere, Marie-Emmanuelle, Langlois, Carolyn, Rouzade-Dominguez, Marie-Laure, Zalesak, Martin, Hendrix, Suzanne, Thomas, Ronald G., Viglietta, Vissia, Lenz, Rob, Ryan, J. Michael, Graf, Ana, Reiman, Eric M.
Publicado 2019

The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate ef...

por Tariot, Pierre N., Lopera, Francisco, Langbaum, Jessica B., Thomas, Ronald G., Hendrix, Suzanne, Schneider, Lon S., Rios-Romenets, Silvia, Giraldo, Margarita, Acosta, Natalia, Tobon, Carlos, Ramos, Claudia, Espinosa, Alejandro, Cho, William, Ward, Michael, Clayton, David, Friesenhahn, Michael, Mackey, Howard, Honigberg, Lee, Sanabria Bohorquez, Sandra, Chen, Kewei, Walsh, Trisha, Langlois, Carolyn, Reiman, Eric M.
Publicado 2018

Recruitment of a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial

por Shadyab, Aladdin H., LaCroix, Andrea Z., Feldman, Howard H., van Dyck, Christopher H., Okonkwo, Ozioma C., Tam, Steven P., Fairchild, J. Kaci, Welsh‐Bohmer, Kathleen A., Matthews, Genevieve, Bennett, Daniel, Shadyab, Alexandre A., Schafer, Kimberly A., Morrison, Rosemary H., Kipperman, Sean A., Mason, Jennifer, Tan, Donna, Thomas, Ronald G., Cotman, Carl W., Baker, Laura D.
Publicado 2021

PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer’s disease-causing Presenilin-1 E280A mutation carriers

por Ghisays, Valentina, Lopera, Francisco, Goradia, Dhruman D., Protas, Hillary D., Malek-Ahmadi, Michael H., Chen, Yinghua, Devadas, Vivek, Luo, Ji, Lee, Wendy, Baena, Ana, Bocanegra, Yamile, Guzmán-Vélez, Edmarie, Pardilla-Delgado, Enmanuelle, Vila-Castelar, Clara, Fox-Fuller, Joshua T., Hu, Nan, Clayton, David, Thomas, Ronald G., Alvarez, Sergio, Espinosa, Alejandro, Acosta-Baena, Natalia, Giraldo, Margarita M., Rios-Romenets, Silvia, Langbaum, Jessica B., Chen, Kewei, Su, Yi, Tariot, Pierre N., Quiroz, Yakeel T., Reiman, Eric M.
Publicado 2021

Baseline demographic, clinical, and cognitive characteristics of the Alzheimer's Prevention Initiative (API) Autosomal‐Dominant Alzheimer's Disease Colombia Trial

por Rios‐Romenets, Silvia, Lopera, Francisco, Sink, Kaycee M., Hu, Nan, Lian, Qinshu, Guthrie, Heather, Smith, Jillian, Cho, William, Mackey, Howard, Langbaum, Jessica B., Thomas, Ronald G., Giraldo‐Chica, Margarita, Tobon, Carlos, Acosta‐Baena, Natalia, Muñoz, Claudia, Ospina, Paula, Tirado, Victoria, Henao, Eliana, Bocanegra, Yamile, Chen, Kewei, Su, Yi, Goradia, Dhruman, Thiyyagura, Pradeep, VanGilder, Paul S., Luo, Ji, Ghisays, Valentina, Lee, Wendy, Malek‐Ahmadi, Michael H., Protas, Hillary D., Chen, Yinghua, Quiroz, Yakeel T., Reiman, Eric M., Tariot, Pierre N.
Publicado 2020