Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

por DeKeyser, Jean-Marc, Thompson, Christopher H., George, Alfred L.
Publicado 2021

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

por Thompson, Christopher H., Ben-Shalom, Roy, Bender, Kevin J., George, Alfred L.
Publicado 2020

Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy

por Gertler, Tracy S., Thompson, Christopher H., Vanoye, Carlos G., Millichap, John J., George, Alfred L.
Publicado 2019

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

por Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.
Publicado 2017

Functional and pharmacological evaluation of a novel SCN2A variant linked to early‐onset epilepsy

por Adney, Scott K., Millichap, John J., DeKeyser, Jean‐Marc, Abramova, Tatiana, Thompson, Christopher H., George, Alfred L.
Publicado 2020

Epilepsy-associated SCN2A (Na(V)1.2) Variants Exhibit Diverse and Complex Functional Properties

por Thompson, Christopher H., Potet, Franck, Abramova, Tatiana V., DeKeyser, Jean-Marc, Ghabra, Nora F., Vanoye, Carlos G., Millichap, John, George, Alfred L.
Publicado 2023

Epilepsy-associated SCN2A (Na(V)1.2) variants exhibit diverse and complex functional properties

por Thompson, Christopher H., Potet, Franck, Abramova, Tatiana V., DeKeyser, Jean-Marc, Ghabra, Nora F., Vanoye, Carlos G., Millichap, John J., George, Alfred L.
Publicado 2023

Scanning mutagenesis of the voltage-gated sodium channel Na(V)1.2 using base editing

por Pablo, Juan Lorenzo B., Cornett, Savannah L., Wang, Lei A., Jo, Sooyeon, Brünger, Tobias, Budnik, Nikita, Hegde, Mudra, DeKeyser, Jean-Marc, Thompson, Christopher H., Doench, John G., Lal, Dennis, George, Alfred L., Pan, Jen Q.
Publicado 2023

Cellular and behavioral effects of altered Na(V)1.2 sodium channel ion permeability in Scn2a(K1422E) mice

por Echevarria-Cooper, Dennis M, Hawkins, Nicole A, Misra, Sunita N, Huffman, Alexandra M, Thaxton, Tyler, Thompson, Christopher H, Ben-Shalom, Roy, Nelson, Andrew D, Lipkin, Anna M, George Jr, Alfred L, Bender, Kevin J, Kearney, Jennifer A
Publicado 2022