IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

por Barlow, Nicholas, Thompson, Philip E.
Publicado 2020

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

por Miller, Michelle S., Thompson, Philip E., Gabelli, Sandra B.
Publicado 2019

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

por Costacurta, Matteo, He, Jackson, Thompson, Philip E., Shortt, Jake
Publicado 2021

Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist—Implications for male fertility

por Eise, Nicole T., Simpson, Jamie S., Thompson, Philip E., Ventura, Sabatino
Publicado 2022

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

por Velkov, Tony, Roberts, Kade D., Nation, Roger L., Wang, Jiping, Thompson, Philip E., Li, Jian
Publicado 2014

Design and Evaluation of Novel Polymyxin Fluorescent Probes

por Yun, Bo, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Velkov, Tony, Li, Jian
Publicado 2017

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

por Li, Mengyao, Azad, Mohammad A. K., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Zhu, Yan, Li, Jian
Publicado 2023

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

por Chai, Siew Yeen, Yeatman, Holly R, Parker, Michael W, Ascher, David B, Thompson, Philip E, Mulvey, Hayley T, Albiston, Anthony L
Publicado 2008

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

por Deris, Zakuan Z., Akter, Jesmin, Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Li, Jian, Velkov, Tony
Publicado 2013

Thiazolidinedione-Based PI3Kα Inhibitors: An Analysis of Biochemical and Virtual Screening Methods

por Pinson, Jo-Anne, Schmidt-Kittler, Oleg, Zhu, Jiuxiang, Jennings, Ian G, Kinzler, Kenneth W, Vogelstein, Bert, Chalmers, David K, Thompson, Philip E
Publicado 2011

The major human and mouse granzymes are structurally and functionally divergent

por Kaiserman, Dion, Bird, Catherina H., Sun, Jiuru, Matthews, Antony, Ung, Kheng, Whisstock, James C., Thompson, Philip E., Trapani, Joseph A., Bird, Phillip I.
Publicado 2006

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

por Zhao, Jinxin, Cheah, Soon-Ee, Roberts, Kade D., Nation, Roger L., Thompson, Philip E., Velkov, Tony, Du, Zongjun, Johnson, Matthew D., Li, Jian
Publicado 2016

TNP Analogues Inhibit the Virulence Promoting IP(3-4) Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

por Desmarini, Desmarini, Truong, Daniel, Wilkinson-White, Lorna, Desphande, Chandrika, Torrado, Mario, Mackay, Joel P., Matthews, Jacqueline M., Sorrell, Tania C., Lev, Sophie, Thompson, Philip E., Djordjevic, Julianne Teresa
Publicado 2022

Structural basis of nSH2 regulation and lipid binding in PI3Kα

por Miller, Michelle S., Schmidt-Kittler, Oleg, Bolduc, David M., Brower, Evan T., Chaves-Moreira, Daniele, Allaire, Marc, Kinzler, Kenneth W., Jennings, Ian G., Thompson, Philip E., Cole, Philip A., Amzel, L. Mario, Vogelstein, Bert, Gabelli, Sandra B.
Publicado 2014

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

por Azad, Mohammad A. K., Roberts, Kade D., Yu, Heidi H., Liu, Boyin, Schofield, Alice V., James, Simon A., Howard, Daryl L., Nation, Roger L., Rogers, Kelly, de Jonge, Martin D., Thompson, Philip E., Fu, Jing, Velkov, Tony, Li, Jian
Publicado 2015

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

por Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Publicado 2016

P1212: RATIONALLY DESIGNED CHIMERIC PI3K-BET BROMODOMAIN INHIBITORS ELICIT CURATIVE RESPONSES IN MYC-DRIVEN LYMPHOMA

por Oh, Danielle H., MA, Xiao, He, Jackson, Kearney, Conor, Hogg, Simon J., Newbold, Andrea, Fraser, Peter, Jennings, Ian G., Brasacchio, Daniella, Susanto, Olivia, Yew Fong, Chun, Dawson, Mark A., Gruber, Emily, Kats, Lev, Johnstone, Ricky W., Thompson, Philip E., Shortt, Jake
Publicado 2023

An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

por Zainal Abidin, Nurul A., Poon, Eric K. W., Szydzik, Crispin, Timofeeva, Mariia, Akbaridoust, Farzan, Brazilek, Rose J., Tovar Lopez, Francisco J., Ma, Xiao, Lav, Chitrarth, Marusic, Ivan, Thompson, Philip E., Mitchell, Arnan, Ooi, Andrew S. H., Hamilton, Justin R., Nesbitt, Warwick S.
Publicado 2022

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

por Jiang, Xukai, Patil, Nitin A., Azad, Mohammad A. K., Wickremasinghe, Hasini, Yu, Heidi, Zhao, Jinxin, Zhang, Xinru, Li, Mengyao, Gong, Bin, Wan, Lin, Ma, Wendong, Thompson, Philip E., Yang, Kai, Yuan, Bing, Schreiber, Falk, Wang, Lushan, Velkov, Tony, Roberts, Kade D., Li, Jian
Publicado 2021

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

por Roberts, Kade D., Zhu, Yan, Azad, Mohammad A. K., Han, Mei-Ling, Wang, Jiping, Wang, Lynn, Yu, Heidi H., Horne, Andrew S., Pinson, Jo-Anne, Rudd, David, Voelcker, Nicolas H., Patil, Nitin A., Zhao, Jinxin, Jiang, Xukai, Lu, Jing, Chen, Ke, Lomovskaya, Olga, Hecker, Scott J., Thompson, Philip E., Nation, Roger L., Dudley, Michael N., Griffith, David C., Velkov, Tony, Li, Jian
Publicado 2022