Favipiravir elicits antiviral mutagenesis during virus replication in vivo

por Arias, Armando, Thorne, Lucy, Goodfellow, Ian
Publicado 2014

Advances Toward a Norovirus Antiviral: From Classical Inhibitors to Lethal Mutagenesis

por Thorne, Lucy, Arias, Armando, Goodfellow, Ian
Publicado 2016

Identification of Protein Interacting Partners Using Tandem Affinity Purification

por Bailey, Dalan, Urena, Luis, Thorne, Lucy, Goodfellow, Ian
Publicado 2012

miR-155 induction is a marker of murine norovirus infection but does not contribute to control of replication in vivo

por Thorne, Lucy, Lu, Jia, Chaudhry, Yasmin, Goodfellow, Ian
Publicado 2018

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

por Arias, Armando, Thorne, Lucy, Ghurburrun, Elsa, Bailey, Dalan, Goodfellow, Ian
Publicado 2016

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

por Arias, Armando, Ureña, Luis, Thorne, Lucy, Yunus, Muhammad A., Goodfellow, Ian
Publicado 2012

Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

por Borg, Constantina, Jahun, Aminu S., Thorne, Lucy, Sorgeloos, Frédéric, Bailey, Dalan, Goodfellow, Ian G.
Publicado 2021

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

por Sumner, Rebecca P., Thorne, Lucy G., Fink, Doug L., Khan, Hataf, Milne, Richard S., Towers, Greg J.
Publicado 2017

Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases

por Lin, Xiaoyan, Thorne, Lucy, Jin, Zhinan, Hammad, Loubna A., Li, Serena, Deval, Jerome, Goodfellow, Ian G., Kao, C. Cheng
Publicado 2015

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

por Thorne, Lucy G, Reuschl, Ann‐Kathrin, Zuliani‐Alvarez, Lorena, Whelan, Matthew V X, Turner, Jane, Noursadeghi, Mahdad, Jolly, Clare, Towers, Greg J
Publicado 2021

Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment

por De Riva, Alessandra, Wållberg, Maja, Ronchi, Francesca, Coulson, Richard, Sage, Andrew, Thorne, Lucy, Goodfellow, Ian, McCoy, Kathy D., Azuma, Miyuki, Cooke, Anne, Busch, Robert
Publicado 2017

SARS-CoV-2 evolution influences GBP and IFITM sensitivity

por Mesner, Dejan, Reuschl, Ann-Kathrin, Whelan, Matthew V. X., Bronzovich, Taylor, Haider, Tafhima, Thorne, Lucy G., Ragazzini, Roberta, Bonfanti, Paola, Towers, Greg J., Jolly, Clare
Publicado 2023

Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine–Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2

por McCune, Broc T., Tang, Wei, Lu, Jia, Eaglesham, James B., Thorne, Lucy, Mayer, Anne E., Condiff, Emily, Nice, Timothy J., Goodfellow, Ian, Krezel, Andrzej M., Virgin, Herbert W.
Publicado 2017

SARS-CoV-2 variant biology: immune escape, transmission and fitness

por Carabelli, Alessandro M., Peacock, Thomas P., Thorne, Lucy G., Harvey, William T., Hughes, Joseph, Peacock, Sharon J., Barclay, Wendy S., de Silva, Thushan I., Towers, Greg J., Robertson, David L.
Publicado 2023

The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors

por Thorne, Lucy, Nalwoga, Angela, Mentzer, Alexander J, de Rougemont, Alexis, Hosmillo, Myra, Webb, Emily, Nampiija, Margaret, Muhwezi, Allan, Carstensen, Tommy, Gurdasani, Deepti, Hill, Adrian V, Sandhu, Manj S, Elliott, Alison, Goodfellow, Ian
Publicado 2018

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

por Khan, Hataf, Sumner, Rebecca P, Rasaiyaah, Jane, Tan, Choon Ping, Rodriguez-Plata, Maria Teresa, Van Tulleken, Chris, Fink, Douglas, Zuliani-Alvarez, Lorena, Thorne, Lucy, Stirling, David, Milne, Richard SB, Towers, Greg J
Publicado 2020

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

por Petrillo, Carolina, Thorne, Lucy G., Unali, Giulia, Schiroli, Giulia, Giordano, Anna M.S., Piras, Francesco, Cuccovillo, Ivan, Petit, Sarah J., Ahsan, Fatima, Noursadeghi, Mahdad, Clare, Simon, Genovese, Pietro, Gentner, Bernhard, Naldini, Luigi, Towers, Greg J., Kajaste-Rudnitski, Anna
Publicado 2018

Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2.

por Dicken, Samuel J., Murray, Matthew J., Thorne, Lucy G., Reuschl, Ann-Kathrin, Forrest, Calum, Ganeshalingham, Maaroothen, Muir, Luke, Kalemera, Mphatso D., Palor, Machaela, McCoy, Laura E., Jolly, Clare, Towers, Greg J., Reeves, Matthew B., Grove, Joe
Publicado 2021

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

por Reuschl, Ann-Kathrin, Thorne, Lucy G., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Hiatt, Joseph, Soucheray, Margaret, Turner, Jane, Fabius, Jacqueline M., Nguyen, Gina T., Swaney, Danielle L., Rosales, Romel, White, Kris M., Avilés, Pablo, Kirby, Ilsa T., Melnyk, James E., Shi, Ying, Zhang, Ziyang, Shokat, Kevan M., García-Sastre, Adolfo, Jolly, Clare, Towers, Gregory J., Krogan, Nevan J.
Publicado 2021

Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial

por Dunning, Jake, Sahr, Foday, Rojek, Amanda, Gannon, Fiona, Carson, Gail, Idriss, Baimba, Massaquoi, Thomas, Gandi, Regina, Joseph, Sebatu, Osman, Hassan K., Brooks, Timothy J. G., Simpson, Andrew J. H., Goodfellow, Ian, Thorne, Lucy, Arias, Armando, Merson, Laura, Castle, Lyndsey, Howell-Jones, Rebecca, Pardinaz-Solis, Raul, Hope-Gill, Benjamin, Ferri, Mauricio, Grove, Jennifer, Kowalski, Mark, Stepniewska, Kasia, Lang, Trudie, Whitehead, John, Olliaro, Piero, Samai, Mohammed, Horby, Peter W.
Publicado 2016