Structural Comparison of a Promiscuous and a Highly Specific Sucrose 6(F)-Phosphate Phosphorylase

por Franceus, Jorick, Capra, Nikolas, Desmet, Tom, Thunnissen, Andy-Mark W.H.
Publicado 2019

Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid

por Mayer, Clemens, Dulson, Christopher, Reddem, Eswar, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard
Publicado 2019

Using Mutability Landscapes To Guide Enzyme Thermostabilization

por Guo, Chao, Ni, Yan, Biewenga, Lieuwe, Pijning, Tjaard, Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J.
Publicado 2020

Crystal Structures of Two Transcriptional Regulators from Bacillus cereus Define the Conserved Structural Features of a PadR Subfamily

por Fibriansah, Guntur, Kovács, Ákos T., Pool, Trijntje J., Boonstra, Mirjam, Kuipers, Oscar P., Thunnissen, Andy-Mark W. H.
Publicado 2012

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme

por Xu, Guangcai, Kunzendorf, Andreas, Crotti, Michele, Rozeboom, Henriëtte J., Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J.
Publicado 2021

Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted l-aspartic acids

por Abidin, Mohammad Z., Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Publicado 2021

Structural Basis for the Catalytic Mechanism of Ethylenediamine-N,N′-disuccinic Acid Lyase, a Carbon–Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope

por Poddar, Harshwardhan, de Villiers, Jandré, Zhang, Jielin, Puthan Veetil, Vinod, Raj, Hans, Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Publicado 2018

Ligand Binding and Crystal Structures of the Substrate-Binding Domain of the ABC Transporter OpuA

por Wolters, Justina C., Berntsson, Ronnie P-A., Gul, Nadia, Karasawa, Akira, Thunnissen, Andy-Mark W. H., Slotboom, Dirk-Jan, Poolman, Bert
Publicado 2010

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

por Zhang, Jielin, Grandi, Eleonora, Fu, Haigen, Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J.
Publicado 2019

Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme

por Villarino, Lara, Chordia, Shreyans, Alonso-Cotchico, Lur, Reddem, Eswar, Zhou, Zhi, Thunnissen, Andy Mark W. H., Maréchal, Jean-Didier, Roelfes, Gerard
Publicado 2020

Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

por Kunzendorf, Andreas, Xu, Guangcai, van der Velde, Jesse J. H., Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Publicado 2021

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

por Shao, Jinfeng, Kuiper, Bastiaan P., Thunnissen, Andy-Mark W. H., Cool, Robbert H., Zhou, Liang, Huang, Chenxi, Dijkstra, Bauke W., Broos, Jaap
Publicado 2022

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium

por Jóźwik, Ilona K., Kiss, Flora M., Gricman, Łukasz, Abdulmughni, Ammar, Brill, Elisa, Zapp, Josef, Pleiss, Juergen, Bernhardt, Rita, Thunnissen, Andy‐Mark W. H.
Publicado 2016

An Artificial Heme Enzyme for Cyclopropanation Reactions

por Villarino, Lara, Splan, Kathryn E., Reddem, Eswar, Alonso‐Cotchico, Lur, Gutiérrez de Souza, Cora, Lledós, Agustí, Maréchal, Jean‐Didier, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard
Publicado 2018

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

por Meng, Qinglong, Capra, Nikolas, Palacio, Cyntia M., Lanfranchi, Elisa, Otzen, Marleen, van Schie, Luc Z., Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Wijma, Hein J., Janssen, Dick B.
Publicado 2020

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

por Meng, Qinglong, Ramírez-Palacios, Carlos, Capra, Nikolas, Hooghwinkel, Mattijs E., Thallmair, Sebastian, Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Wijma, Hein J., Marrink, Siewert J., Janssen, Dick B.
Publicado 2021

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

por Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, van der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Publicado 2019

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

por van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G., Geertsema, Edzard M., Thunnissen, Andy-Mark W. H., Quax, Wim J., Poelarends, Gerrit J.
Publicado 2016