Peroxide-cleavable linkers for antibody–drug conjugates

por Ashman, Nicola, Bargh, Jonathan D., Walsh, Stephen J., Greenwood, Ryan D., Tiberghien, Arnaud, Carroll, Jason S., Spring, David R.
Publicado 2023

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

por Christie, R. James, Tiberghien, Arnaud C., Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip W., Gao, Changshou
Publicado 2017

A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

por MacGregor, Paula, Gonzalez-Munoz, Andrea L., Jobe, Fatoumatta, Taylor, Martin C., Rust, Steven, Sandercock, Alan M., Macleod, Olivia J. S., Van Bocxlaer, Katrien, Francisco, Amanda F., D’Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S., Howard, Philip, Higgins, Matthew K., Vaughan, Tristan J., Minter, Ralph, Carrington, Mark
Publicado 2019

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

por Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Publicado 2018