The diamidine DB75 targets the nucleus of Plasmodium falciparum

por Purfield, Anne E, Tidwell, Richard R, Meshnick, Steven R
Publicado 2009

Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach

por Buckner, Frederick S., Buchynskyy, Andriy, Nagendar, Pendem, Patrick, Donald A., Gillespie, J. Robert, Herbst, Zackary, Tidwell, Richard R., Gelb, Michael H.
Publicado 2020

A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model

por Wasan, Ellen K., Gershkovich, Pavel, Zhao, Jinying, Zhu, Xiaohua, Werbovetz, Karl, Tidwell, Richard R., Clement, John G., Thornton, Sheila J., Wasan, Kishor M.
Publicado 2010

Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

por Mumba, Dieudonne, Bohorquez, Elaine, Messina, Jane, Kande, Victor, Taylor, Steven M., Tshefu, Antoinette K., Muwonga, Jeremie, Kashamuka, Melchior M., Emch, Michael, Tidwell, Richard, Büscher, Philippe, Meshnick, Steven R.
Publicado 2011

A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models

por Harrill, Alison H., DeSmet, Kristina D., Wolf, Kristina K., Bridges, Arlene S., Eaddy, J. Scott, Kurtz, C. Lisa, Hall, J. Ed., Paine, Mary F., Tidwell, Richard R., Watkins, Paul B.
Publicado 2012

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

por Thuita, John K., Wang, Michael Z., Kagira, John M., Denton, Cathrine L., Paine, Mary F., Mdachi, Raymond E., Murilla, Grace A., Ching, Shelley, Boykin, David W., Tidwell, Richard R., Hall, James E., Brun, Reto
Publicado 2012

Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys

por Thuita, John K., Wolf, Kristina K., Murilla, Grace A., Bridges, Arlene S., Boykin, David W., Mutuku, James N., Liu, Qiang, Jones, Susan K., Gem, Charles O., Ching, Shelley, Tidwell, Richard R., Wang, Michael Z., Paine, Mary F., Brun, Reto
Publicado 2015

Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis

por Thuita, John K., Wolf, Kristina K., Murilla, Grace A., Liu, Qiang, Mutuku, James N., Chen, Yao, Bridges, Arlene S., Mdachi, Raymond E., Ismail, Mohamed A., Ching, Shelley, Boykin, David W., Hall, James Edwin, Tidwell, Richard R., Paine, Mary F., Brun, Reto, Wang, Michael Zhuo
Publicado 2013

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

por Burri, Christian, Yeramian, Patrick D., Allen, James L., Merolle, Ada, Serge, Kazadi Kyanza, Mpanya, Alain, Lutumba, Pascal, Mesu, Victor Kande Betu Ku, Bilenge, Constantin Miaka Mia, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Thompson, Mark, Munungu, Blaise Fungula, Manuel, Francisco, Josenando, Théophilo, Bernhard, Sonja C., Olson, Carol A., Blum, Johannes, Tidwell, Richard R., Pohlig, Gabriele
Publicado 2016

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical...

por Pohlig, Gabriele, Bernhard, Sonja C., Blum, Johannes, Burri, Christian, Mpanya, Alain, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Munungu, Blaise Fungula, N’tombe, Patrick Mangoni, Deo, Gratias Kambau Manesa, Mutantu, Pierre Nsele, Kuikumbi, Florent Mbo, Mintwo, Alain Fukinsia, Munungi, Augustin Kayeye, Dala, Amadeu, Macharia, Stephen, Bilenge, Constantin Miaka Mia, Mesu, Victor Kande Betu Ku, Franco, Jose Ramon, Dituvanga, Ndinga Dieyi, Tidwell, Richard R., Olson, Carol A.
Publicado 2016

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

por Alghamdi, Ali H, Munday, Jane C, Campagnaro, Gustavo Daniel, Gurvic, Dominik, Svensson, Fredrik, Okpara, Chinyere E, Kumar, Arvind, Quintana, Juan, Martin Abril, Maria Esther, Milić, Patrik, Watson, Laura, Paape, Daniel, Settimo, Luca, Dimitriou, Anna, Wielinska, Joanna, Smart, Graeme, Anderson, Laura F, Woodley, Christopher M, Kelly, Siu Pui Ying, Ibrahim, Hasan MS, Hulpia, Fabian, Al-Salabi, Mohammed I, Eze, Anthonius A, Sprenger, Teresa, Teka, Ibrahim A, Gudin, Simon, Weyand, Simone, Field, Mark, Dardonville, Christophe, Tidwell, Richard R, Carrington, Mark, O'Neill, Paul, Boykin, David W, Zachariae, Ulrich, De Koning, Harry P
Publicado 2020