Free fatty acid receptors: structural models and elucidation of ligand binding interactions

por Tikhonova, Irina G., Poerio, Elena
Publicado 2015

Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations

por Ding, Tianyi, Karlov, Dmitry S., Pino-Angeles, Almudena, Tikhonova, Irina G.
Publicado 2022

Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase

por Moore, Daniel S., Brines, Conor, Jewhurst, Heather, Dalton, John P., Tikhonova, Irina G.
Publicado 2018

An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica

por Smith, David, Cwiklinski, Krystyna, Jewhurst, Heather, Tikhonova, Irina G., Dalton, John P.
Publicado 2020

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

por Hudson, Brian D., Tikhonova, Irina G., Pandey, Sunil K., Ulven, Trond, Milligan, Graeme
Publicado 2012

Simulations of Biased Agonists in the β(2) Adrenergic Receptor with Accelerated Molecular Dynamics

por Tikhonova, Irina G., Selvam, Balaji, Ivetac, Anthony, Wereszczynski, Jeff, McCammon, J. Andrew
Publicado 2013

The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity

por Xu, Fuzhou, Hu, Xiao-Jian, Singh, Warispreet, Geng, Wenjing, Tikhonova, Irina G., Lin, Jun
Publicado 2019

Structural basis for the ligand recognition and signaling of free fatty acid receptors

por Zhang, Xuan, Guseinov, Abdul-Akim, Jenkins, Laura, Li, Kunpeng, Tikhonova, Irina G., Milligan, Graeme, Zhang, Cheng
Publicado 2023

β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

por Daly, Carole, Guseinov, Akim Abdul, Hahn, Hyunggu, Wright, Adam, Tikhonova, Irina G., Thomsen, Alex Rojas Bie, Plouffe, Bianca
Publicado 2023

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

por Daly, Carole, Guseinov, Akim Abdul, Hahn, Hyunggu, Wright, Adam, Tikhonova, Irina G, Thomsen, Alex Rojas Bie, Plouffe, Bianca
Publicado 2023

Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction

por Ciancetta, Antonella, Gill, Amandeep Kaur, Ding, Tianyi, Karlov, Dmitry S., Chalhoub, George, McCormick, Peter J., Tikhonova, Irina G.
Publicado 2021

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

por Hudson, Brian D., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Kostenis, Evi, Adams, David R., Ulven, Trond, Milligan, Graeme
Publicado 2012

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases

por De Marco Verissimo, Carolina, Jewhurst, Heather L., Tikhonova, Irina G., Urbanus, Rolf T., Maule, Aaron G., Dalton, John P., Cwiklinski, Krystyna
Publicado 2020

Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES

por Smith, David, Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla C., Dvořák, Jan, Robinson, Mark W., Cwiklinski, Krystyna, Dalton, John P.
Publicado 2016

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

por Olatunji, Samir, Bowen, Katherine, Huang, Chia-Ying, Weichert, Dietmar, Singh, Warispreet, Tikhonova, Irina G., Scanlan, Eoin M., Olieric, Vincent, Caffrey, Martin
Publicado 2021

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

por Mahmud, Zobaer Al, Jenkins, Laura, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D., Tikhonova, Irina G., Milligan, Graeme
Publicado 2017

Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

por Pritsch, Izanara C., Tikhonova, Irina G., Jewhurst, Heather L., Drysdale, Orla, Cwiklinski, Krystyna, Molento, Marcelo B., Dalton, John P., Verissimo, Carolina De M.
Publicado 2020

Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart

por Yoval-Sánchez, Belem, Ansari, Fariha, James, Joel, Niatsetskaya, Zoya, Sosunov, Sergey, Filipenko, Peter, Tikhonova, Irina G., Ten, Vadim, Wittig, Ilka, Rafikov, Ruslan, Galkin, Alexander
Publicado 2022

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3

por Schmidt, Johannes, Smith, Nicola J., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Hudson, Brian D., Ward, Richard J., Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Publicado 2011

Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands

por Marsango, Sara, Ward, Richard J., Jenkins, Laura, Butcher, Adrian J., Al Mahmud, Zobaer, Dwomoh, Louis, Nagel, Falko, Schulz, Stefan, Tikhonova, Irina G., Tobin, Andrew B., Milligan, Graeme
Publicado 2022