Cancer Therapy-Induced Cardiotoxicity—A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy

por Choksey, Anurag, Timm, Kerstin N.
Publicado 2021

The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity

por Timm, Kerstin N., Tyler, Damian J.
Publicado 2020

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

por Timm, Kerstin N., Apps, Andrew, Miller, Jack J., Ball, Vicky, Chong, Cher‐Rin, Dodd, Michael S., Tyler, Damian J.
Publicado 2018

A 3D hybrid-shot spiral sequence for hyperpolarized (13)C imaging

por Tyler, Andrew, Lau, Justin Y. C., Ball, Vicky, Timm, Kerstin N., Zhou, Tony, Tyler, Damian J., Miller, Jack J.
Publicado 2021

Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics

por Timm, Kerstin N., Ball, Vicky, Miller, Jack J., Savic, Dragana, West, James A., Griffin, Julian L., Tyler, Damian J.
Publicado 2022

Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic fun...

por Savic, Dragana, Ball, Vicky, Holzner, Lorenz, Hauton, David, Timm, Kerstin N., Curtis, M. Kate, Heather, Lisa C., Tyler, Damian J.
Publicado 2021

Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol

por Kerr, Matthew, Miller, Jack J., Thapa, Dharendra, Stiewe, Sophie, Timm, Kerstin N., Aparicio, Claudia N. Montes, Scott, Iain, Tyler, Damian J., Heather, Lisa C.
Publicado 2020

Probing hepatic metabolism of [2-(13)C]dihydroxyacetone in vivo with (1)H-decoupled hyperpolarized (13)C-MR

por Marco-Rius, Irene, Wright, Alan J., Hu, De-en, Savic, Dragana, Miller, Jack J., Timm, Kerstin N., Tyler, Damian, Brindle, Kevin M., Comment, Arnaud
Publicado 2020

L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI

por Savic, Dragana, Ball, Vicky, Curtis, M. Kate, Sousa Fialho, Maria da Luz, Timm, Kerstin N., Hauton, David, West, James, Griffin, Julian, Heather, Lisa C., Tyler, Damian J.
Publicado 2021

Rapid, [Formula: see text] ‐insensitive, dual‐band quasi‐adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux

por Miller, Jack J., Valkovič, Ladislav, Kerr, Matthew, Timm, Kerstin N., Watson, William D., Lau, Justin Y. C., Tyler, Andrew, Rodgers, Christopher, Bottomley, Paul A., Heather, Lisa C., Tyler, Damian J.
Publicado 2021

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-(13)C]Dehydroascorbic Acid Reduction Using (13)C Magnetic Resonance Spectroscopy

por Timm, Kerstin N., Hu, De-En, Williams, Michael, Wright, Alan J., Kettunen, Mikko I., Kennedy, Brett W. C., Larkin, Timothy J., Dzien, Piotr, Marco-Rius, Irene, Bohndiek, Sarah E., Brindle, Kevin M.
Publicado 2017

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse

por Marco-Rius, Irene, Tayler, Michael C D, Kettunen, Mikko I, Larkin, Timothy J, Timm, Kerstin N, Serrao, Eva M, Rodrigues, Tiago B, Pileio, Giuseppe, Ardenkjaer-Larsen, Jan Henrik, Levitt, Malcolm H, Brindle, Kevin M
Publicado 2013

Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

por Dodd, Michael S., Sousa Fialho, Maria da Luz, Montes Aparicio, Claudia N., Kerr, Matthew, Timm, Kerstin N., Griffin, Julian L., Luiken, Joost J.F.P., Glatz, Jan F.C., Tyler, Damian J., Heather, Lisa C.
Publicado 2018

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI

por Timm, Kerstin N., Perera, Charith, Ball, Vicky, Henry, John A., Miller, Jack J., Kerr, Matthew, West, James A., Sharma, Eshita, Broxholme, John, Logan, Angela, Savic, Dragana, Dodd, Michael S., Griffin, Julian L., Murphy, Michael P., Heather, Lisa C., Tyler, Damian J.
Publicado 2020

(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo...

por Dzien, Piotr, Tee, Sui‐Seng, Kettunen, Mikko I., Lyons, Scott K., Larkin, Timothy J., Timm, Kerstin N., Hu, De‐En, Wright, Alan, Rodrigues, Tiago B., Serrao, Eva M., Marco‐Rius, Irene, Mannion, Elizabeth, D'Santos, Paula, Kennedy, Brett W. C., Brindle, Kevin M.
Publicado 2015