Tying up loose ends: the N-degron and C-degron pathways of protein degradation

por Timms, Richard T., Koren, Itay
Publicado 2020

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

por Timms, Richard T., Tchasovnikarova, Iva A., Antrobus, Robin, Dougan, Gordon, Lehner, Paul J.
Publicado 2016

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

por Zhang, Zhiqian, Sie, Brandon, Chang, Aiquan, Leng, Yumei, Nardone, Christopher, Timms, Richard T., Elledge, Stephen J.
Publicado 2023

Fluorescence-Based Phenotypic Selection Allows Forward Genetic Screens in Haploid Human Cells

por Duncan, Lidia M., Timms, Richard T., Zavodszky, Eszter, Cano, Florencia, Dougan, Gordon, Randow, Felix, Lehner, Paul J.
Publicado 2012

A Genetic Screen Identifies a Critical Role for the WDR81‐WDR91 Complex in the Trafficking and Degradation of Tetherin

por Rapiteanu, Radu, Davis, Luther J., Williamson, James C., Timms, Richard T., Paul Luzio, J., Lehner, Paul J.
Publicado 2016

Defining E3 ligase–substrate relationships through multiplex CRISPR screening

por Timms, Richard T., Mena, Elijah L., Leng, Yumei, Li, Mamie Z., Tchasovnikarova, Iva A., Koren, Itay, Elledge, Stephen J.
Publicado 2023

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

por Douse, Christopher H., Bloor, Stuart, Liu, Yangci, Shamin, Maria, Tchasovnikarova, Iva A., Timms, Richard T., Lehner, Paul J., Modis, Yorgo
Publicado 2018

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

por Menzies, Sam A, Volkmar, Norbert, van den Boomen, Dick JH, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J
Publicado 2018

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

por Timms, Richard T., Duncan, Lidia M., Tchasovnikarova, Iva A., Antrobus, Robin, Smith, Duncan L., Dougan, Gordon, Weekes, Michael P., Lehner, Paul J.
Publicado 2013

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

por Timms, Richard T., Menzies, Sam A., Tchasovnikarova, Iva A., Christensen, Lea C., Williamson, James C., Antrobus, Robin, Dougan, Gordon, Ellgaard, Lars, Lehner, Paul J.
Publicado 2016

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

por Robbez-Masson, Luisa, Tie, Christopher H.C., Conde, Lucia, Tunbak, Hale, Husovsky, Connor, Tchasovnikarova, Iva A., Timms, Richard T., Herrero, Javier, Lehner, Paul J., Rowe, Helen M.
Publicado 2018

Ubiquitin-independent proteasomal degradation driven by C-degron pathways

por Makaros, Yaara, Raiff, Anat, Timms, Richard T., Wagh, Ajay R., Gueta, Mor Israel, Bekturova, Aizat, Guez-Haddad, Julia, Brodsky, Sagie, Opatowsky, Yarden, Glickman, Michael H., Elledge, Stephen J., Koren, Itay
Publicado 2023

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

por Burr, Stephen P., Costa, Ana S.H., Grice, Guinevere L., Timms, Richard T., Lobb, Ian T., Freisinger, Peter, Dodd, Roger B., Dougan, Gordon, Lehner, Paul J., Frezza, Christian, Nathan, James A.
Publicado 2016

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

por Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo
Publicado 2020

Periphilin self-association underpins epigenetic silencing by the HUSH complex

por Prigozhin, Daniil M, Douse, Christopher H, Farleigh, Laura E, Albecka, Anna, Tchasovnikarova, Iva A, Timms, Richard T, Oda, Shun-ichiro, Adolf, Frank, Freund, Stefan M V, Maslen, Sarah, Lehner, Paul J, Modis, Yorgo
Publicado 2020

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses

por Shrock, Ellen L., Timms, Richard T., Kula, Tomasz, Mena, Elijah L., West, Anthony P., Guo, Rui, Lee, I-Hsiu, Cohen, Alexander A., McKay, Lindsay G. A., Bi, Caihong, Keerti, Leng, Yumei, Fujimura, Eric, Horns, Felix, Li, Mamie, Wesemann, Duane R., Griffiths, Anthony, Gewurz, Benjamin E., Bjorkman, Pamela J., Elledge, Stephen J.
Publicado 2023

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

por Shrock, Ellen, Fujimura, Eric, Kula, Tomasz, Timms, Richard T., Lee, I-Hsiu, Leng, Yumei, Robinson, Matthew L., Sie, Brandon M., Li, Mamie Z., Chen, Yuezhou, Logue, Jennifer, Zuiani, Adam, McCulloch, Denise, Lelis, Felipe J. N., Henson, Stephanie, Monaco, Daniel R., Travers, Meghan, Habibi, Shaghayegh, Clarke, William A., Caturegli, Patrizio, Laeyendecker, Oliver, Piechocka-Trocha, Alicja, Li, Jonathan Z., Khatri, Ashok, Chu, Helen Y., Villani, Alexandra-Chloé, Kays, Kyle, Goldberg, Marcia B., Hacohen, Nir, Filbin, Michael R., Yu, Xu G., Walker, Bruce D., Wesemann, Duane R., Larman, H. Benjamin, Lederer, James A., Elledge, Stephen J.
Publicado 2020