Creation of a Peptide Antagonist of the GFRAL–RET Receptor Complex for the Treatment of GDF15-Induced Malaise

por Borner, Tito, Tinsley, Ian C., Milliken, Brandon T., Doebley, Sarah A., Najjar, Nicholas R., Kerwood, Deborah J., De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
Publicado 2023

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

por Tinsley, Ian C., Borner, Tito, Swanson, MacKenzie L., Chepurny, Oleg G., Doebley, Sarah A., Kamat, Varun, Sweet, Ian R., Holz, George G., Hayes, Matthew R., De Jonghe, Bart C., Doyle, Robert P.
Publicado 2021

Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects

por Asker, Mohammed, Krieger, Jean‐Philippe, Liles, Amber, Tinsley, Ian C., Borner, Tito, Maric, Ivana, Doebley, Sarah, Furst, C. Daniel, Börchers, Stina, Longo, Francesco, Bhat, Yashaswini R., De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P., Skibicka, Karolina P.
Publicado 2023