High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington’s Disease Model

por Titus, Steven A, Southall, Noel, Marugan, Juan, Austin, Christopher P, Zheng, Wei
Publicado 2012

A high-throughput imaging and nuclear segmentation analysis protocol for cleared 3D culture models

por Boutin, Molly E., Voss, Ty C., Titus, Steven A., Cruz-Gutierrez, Kennie, Michael, Sam, Ferrer, Marc
Publicado 2018

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado 2017

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

por Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Publicado 2018

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System

por Cheng, Eric, Dorjsuren, Dorjbal, Lehman, Stephanie, Larson, Charles L., Titus, Steven A., Sun, Hongmao, Zakharov, Alexey, Rai, Ganesha, Heinzen, Robert A., Simeonov, Anton, Machner, Matthias P.
Publicado 2022

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets

por Klanert, Gerald, Fernandez, Daniel J., Weinguny, Marcus, Eisenhut, Peter, Bühler, Eugen, Melcher, Michael, Titus, Steven A., Diendorfer, Andreas B., Gludovacz, Elisabeth, Jadhav, Vaibhav, Xiao, Su, Stern, Beate, Lal, Madhu, Shiloach, Joseph, Borth, Nicole
Publicado 2019

Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5

por Stephen, Joshi, Yokoyama, Tadafumi, Tolman, Nathanial J., O’Brien, Kevin J., Nicoli, Elena-Raluca, Brooks, Brian P., Huryn, Laryssa, Titus, Steven A., Adams, David R., Chen, Dong, Gahl, William A., Gochuico, Bernadette R., Malicdan, May Christine V.
Publicado 2017

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology

por Pei, Fen, Li, Hongchun, Henderson, Mark J., Titus, Steven A., Jadhav, Ajit, Simeonov, Anton, Cobanoglu, Murat Can, Mousavi, Seyed H., Shun, Tongying, McDermott, Lee, Iyer, Prema, Fioravanti, Michael, Carlisle, Diane, Friedlander, Robert M., Bahar, Ivet, Taylor, D. Lansing, Lezon, Timothy R., Stern, Andrew M., Schurdak, Mark E.
Publicado 2017

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

por Al-Ramahi, Ismael, Giridharan, Sai Srinivas Panapakkam, Chen, Yu-Chi, Patnaik, Samarjit, Safren, Nathaniel, Hasegawa, Junya, de Haro, Maria, Wagner Gee, Amanda K, Titus, Steven A, Jeong, Hyunkyung, Clarke, Jonathan, Krainc, Dimitri, Zheng, Wei, Irvine, Robin F, Barmada, Sami, Ferrer, Marc, Southall, Noel, Weisman, Lois S, Botas, Juan, Marugan, Juan Jose
Publicado 2017

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

por Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Publicado 2017

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

por Kearney, Sara E., Zahoránszky-Kőhalmi, Gergely, Brimacombe, Kyle R., Henderson, Mark J., Lynch, Caitlin, Zhao, Tongan, Wan, Kanny K., Itkin, Zina, Dillon, Christopher, Shen, Min, Cheff, Dorian M., Lee, Tobie D., Bougie, Danielle, Cheng, Ken, Coussens, Nathan P., Dorjsuren, Dorjbal, Eastman, Richard T., Huang, Ruili, Iannotti, Michael J., Karavadhi, Surendra, Klumpp-Thomas, Carleen, Roth, Jacob S., Sakamuru, Srilatha, Sun, Wei, Titus, Steven A., Yasgar, Adam, Zhang, Ya-Qin, Zhao, Jinghua, Andrade, Rodrigo B., Brown, M. Kevin, Burns, Noah Z., Cha, Jin K., Mevers, Emily E., Clardy, Jon, Clement, Jason A., Crooks, Peter A., Cuny, Gregory D., Ganor, Jake, Moreno, Jesus, Morrill, Lucas A., Picazo, Elias, Susick, Robert B., Garg, Neil K., Goess, Brian C., Grossman, Robert B., Hughes, Chambers C., Johnston, Jeffrey N., Joullie, Madeleine M., Kinghorn, A. Douglas, Kingston, David G.I., Krische, Michael J., Kwon, Ohyun, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mohamed, Enas, Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Brown, Lauren E., Snyder, John K., Porco, John A., Rivas, Fatima, Ross, Samir A., Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Xu, Zhengren, Shen, Ben, Shi, Wei, Stephenson, Corey R.J., Verano, Alyssa L., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Vosburg, David A., Wu, Jimmy, Wuest, William M., Zakarian, Armen, Zhang, Yufeng, Ren, Tianjing, Zuo, Zhong, Inglese, James, Michael, Sam, Simeonov, Anton, Zheng, Wei, Shinn, Paul, Jadhav, Ajit, Boxer, Matthew B., Hall, Matthew D., Xia, Menghang, Guha, Rajarshi, Rohde, Jason M.
Publicado 2018