Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

por Schmid, Manuel, Toepfer, Christopher N.
Publicado 2021

Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (k (tr)) in a length‐dependent fashion

por Toepfer, Christopher N., West, Timothy G., Ferenczi, Michael A.
Publicado 2016

Non-Linear Optical Microscopy Sheds Light on Cardiovascular Disease

por Caorsi, Valentina, Toepfer, Christopher, Sikkel, Markus B., Lyon, Alexander R., MacLeod, Ken, Ferenczi, Mike A.
Publicado 2013

Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy

por Margara, Francesca, Psaras, Yiangos, Wang, Zhinuo Jenny, Schmid, Manuel, Doste, Ruben, Garfinkel, Amanda C., Repetti, Giuliana G., Seidman, Jonathan G., Seidman, Christine E., Rodriguez, Blanca, Toepfer, Christopher N., Bueno-Orovio, Alfonso
Publicado 2022

A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation

por Toepfer, Christopher N., Sikkel, Markus B., Caorsi, Valentina, Vydyanath, Anupama, Torre, Iratxe, Copeland, O'Neal, Lyon, Alexander R., Marston, Steven B., Luther, Pradeep K., Macleod, Kenneth T., West, Timothy G., Ferenczi, Michael A.
Publicado 2016

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

por Toepfer, Christopher, Caorsi, Valentina, Kampourakis, Thomas, Sikkel, Markus B., West, Timothy G., Leung, Man-Ching, Al-Saud, Sara A., MacLeod, Kenneth T., Lyon, Alexander R., Marston, Steven B., Sellers, James R., Ferenczi, Michael A.
Publicado 2013

Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere

por Agarwal, Radhika, Wakimoto, Hiroko, Paulo, Joao A., Zhang, Qi, Reichart, Daniel, Toepfer, Christopher, Sharma, Arun, Tai, Angela C., Lun, Mingyue, Gorham, Joshua, DePalma, Steven R., Gygi, Steven P., Seidman, J.G., Seidman, Christine E.
Publicado 2022

SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes

por Toepfer, Christopher N., Sharma, Arun, Cicconet, Marcelo, Garfinkel, Amanda C., Mücke, Michael, Neyazi, Meraj, Willcox, Jon A.L., Agarwal, Radhika, Schmid, Manuel, Rao, Jyoti, Ewoldt, Jourdan, Pourquié, Olivier, Chopra, Anant, Chen, Christopher S., Seidman, Jonathan G., Seidman, Christine E.
Publicado 2019

CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes

por Psaras, Yiangos, Margara, Francesca, Cicconet, Marcelo, Sparrow, Alexander J., Repetti, Giuliana G., Schmid, Manuel, Steeples, Violetta, Wilcox, Jonathan A.L., Bueno-Orovio, Alfonso, Redwood, Charles S., Watkins, Hugh C., Robinson, Paul, Rodriguez, Blanca, Seidman, Jonathan G., Seidman, Christine E., Toepfer, Christopher N.
Publicado 2021

Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization

por Zhang, Kehan, Cloonan, Paige E., Sundaram, Subramanian, Liu, Feng, Das, Shoshana L., Ewoldt, Jourdan K., Bays, Jennifer L., Tomp, Samuel, Toepfer, Christopher N., Marsiglia, Júlia D. C., Gorham, Joshua, Reichart, Daniel, Eyckmans, Jeroen, Seidman, Jonathan G., Seidman, Christine E., Chen, Christopher S.
Publicado 2021

Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation

por Venturini, Gabriela, Alvim, Juliana M., Padilha, Kallyandra, Toepfer, Christopher N., Gorham, Joshua M., Wasson, Lauren K., Biagi, Diogo, Schenkman, Sergio, Carvalho, Valdemir M., Salgueiro, Jessica S., Cardozo, Karina H. M., Krieger, Jose E., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.
Publicado 2023

Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome

por Meier, Anna B., Raj Murthi, Sarala, Rawat, Hilansi, Toepfer, Christopher N., Santamaria, Gianluca, Schmid, Manuel, Mastantuono, Elisa, Schwarzmayr, Thomas, Berutti, Riccardo, Cleuziou, Julie, Ewert, Peter, Görlach, Agnes, Klingel, Karin, Laugwitz, Karl-Ludwig, Seidman, Christine E., Seidman, Jonathan G., Moretti, Alessandra, Wolf, Cordula M.
Publicado 2021

Comparing the effects of chemical Ca(2+) dyes and R-GECO on contractility and Ca(2+) transients in adult and human iPSC cardiomyocytes

por Robinson, Paul, Sparrow, Alexander J., Psaras, Yiangos, Steeples, Violetta, Simon, Jillian N., Broyles, Connor N., Chang, Yu-Fen, Brook, Frances A., Wang, Ying-Jie, Blease, Andrew, Zhang, Xiaoyu, Abassi, Yama A., Geeves, Michael A., Toepfer, Christopher N., Watkins, Hugh, Redwood, Charles, Daniels, Matthew J.
Publicado 2023

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C(+/−) During Development

por Shafaattalab, Sanam, Li, Alison Y, Jayousi, Farah, Maaref, Yasaman, Dababneh, Saif, Hamledari, Homa, Baygi, Dina Hosseini, Barszczewski, Tiffany, Ruprai, Balwinder, Jannati, Shayan, Nagalingam, Raghu, Cool, Austin M, Langa, Paulina, Chiao, Mu, Roston, Thomas, Solaro, R John, Sanatani, Shubhayan, Toepfer, Christopher, Lindert, Steffen, Lange, Philipp, Tibbits, Glen F
Publicado 2023

Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

por Guo, Yuxuan, Jardin, Blake D., Zhou, Pingzhu, Sethi, Isha, Akerberg, Brynn N., Toepfer, Christopher N, Ai, Yulan, Li, Yifei, Ma, Qing, Guatimosim, Silvia, Hu, Yongwu, Varuzhanyan, Grigor, VanDusen, Nathan J., Zhang, Donghui, Chan, David C., Yuan, Guo-Cheng, Seidman, Christine E., Seidman, Jonathan G., Pu, William T.
Publicado 2018

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

por Toepfer, Christopher N., Garfinkel, Amanda C., Venturini, Gabriela, Wakimoto, Hiroko, Repetti, Giuliana, Alamo, Lorenzo, Sharma, Arun, Agarwal, Radhika, Ewoldt, Jourdan F., Cloonan, Paige, Letendre, Justin, Lun, Mingyue, Olivotto, Iacopo, Colan, Steve, Ashley, Euan, Jacoby, Daniel, Michels, Michelle, Redwood, Charles S., Watkins, Hugh C., Day, Sharlene M., Staples, James F., Padrón, Raúl, Chopra, Anant, Ho, Carolyn Y., Chen, Christopher S., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.
Publicado 2020

GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm

por Sharma, Arun, Wasson, Lauren K, Willcox, Jon AL, Morton, Sarah U, Gorham, Joshua M, DeLaughter, Daniel M, Neyazi, Meraj, Schmid, Manuel, Agarwal, Radhika, Jang, Min Young, Toepfer, Christopher N, Ward, Tarsha, Kim, Yuri, Pereira, Alexandre C, DePalma, Steven R, Tai, Angela, Kim, Seongwon, Conner, David, Bernstein, Daniel, Gelb, Bruce D, Chung, Wendy K, Goldmuntz, Elizabeth, Porter, George, Tristani-Firouzi, Martin, Srivastava, Deepak, Seidman, Jonathan G, Seidman, Christine E
Publicado 2020

Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients

por Pua, Chee Jian, Tham, Nevin, Chin, Calvin W.L., Walsh, Roddy, Khor, Chiea Chuen, Toepfer, Christopher N., Repetti, Giuliana G., Garfinkel, Amanda C., Ewoldt, Jourdan F., Cloonan, Paige, Chen, Christopher S., Lim, Shi Qi, Cai, Jiashen, Loo, Li Yang, Kong, Siew Ching, Chiang, Charleston W.K., Whiffin, Nicola, de Marvao, Antonio, Lio, Pei Min, Hii, An An, Yang, Cheng Xi, Le, Thu Thao, Bylstra, Yasmin, Lim, Weng Khong, Teo, Jing Xian, Padilha, Kallyandra, Silva, Gabriela V., Pan, Bangfen, Govind, Risha, Buchan, Rachel J., Barton, Paul J.R., Tan, Patrick, Foo, Roger, Yip, James W.L., Wong, Raymond C.C., Chan, Wan Xian, Pereira, Alexandre C., Tang, Hak Chiaw, Jamuar, Saumya Shekhar, Ware, James S., Seidman, Jonathan G., Seidman, Christine E., Cook, Stuart A.
Publicado 2020

Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

por Garcia-Pavia, Pablo, Kim, Yuri, Restrepo-Cordoba, Maria Alejandra, Lunde, Ida G., Wakimoto, Hiroko, Smith, Amanda M., Toepfer, Christopher N., Getz, Kelly, Gorham, Joshua, Patel, Parth, Ito, Kaoru, Willcox, Jonathan A., Arany, Zoltan, Li, Jian, Owens, Anjali T., Govind, Risha, Nuñez, Beatriz, Mazaika, Erica, Bayes-Genis, Antoni, Walsh, Roddy, Finkelman, Brian, Lupon, Josep, Whiffin, Nicola, Serrano, Isabel, Midwinter, William, Wilk, Alicja, Bardaji, Alfredo, Ingold, Nathan, Buchan, Rachel, Tayal, Upasana, Pascual-Figal, Domingo A., de Marvao, Antonio, Ahmad, Mian, Garcia-Pinilla, Jose Manuel, Pantazis, Antonis, Dominguez, Fernando, John Baksi, A., O’Regan, Declan P., Rosen, Stuart D., Prasad, Sanjay K., Lara-Pezzi, Enrique, Provencio, Mariano, Lyon, Alexander R., Alonso-Pulpon, Luis, Cook, Stuart A., DePalma, Steven R., Barton, Paul J.R., Aplenc, Richard, Seidman, Jonathan G., Ky, Bonnie, Ware, James S., Seidman, Christine E.
Publicado 2019