A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

por Tofaris, George K.
Publicado 2017

Initiation and progression of α-synuclein pathology in Parkinson’s disease

por Tofaris, George K.
Publicado 2022

Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers

por Yan, Shijun, Jiang, Cheng, Davis, Jason J, Tofaris, George K
Publicado 2023

Intact Acquisition and Short-Term Retention of Non-Motor Procedural Learning in Parkinson’s Disease

por Panouillères, Muriel T. N., Tofaris, George K., Brown, Peter, Jenkinson, Ned
Publicado 2016

Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson’s Disease Diagnostics

por Fu, Ying, Jiang, Cheng, Tofaris, George K., Davis, Jason J.
Publicado 2020

Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson’s Disease Diagnostics

por Sharafeldin, Mohamed, Yan, Shijun, Jiang, Cheng, Tofaris, George K., Davis, Jason J.
Publicado 2023

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

por Jiang, Cheng, Fu, Ying, Liu, Guozhen, Shu, Bowen, Davis, Jason, Tofaris, George K.
Publicado 2021

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

por Zenko, Dmitry, Marsh, Jade, Castle, Andrew R., Lewin, Rahel, Fischer, Roman, Tofaris, George K.
Publicado 2023

Validation of α‐Synuclein in L1CAM‐Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes

por Jiang, Cheng, Hopfner, Franziska, Berg, Daniela, Hu, Michele T., Pilotto, Andrea, Borroni, Barbara, Davis, Jason J., Tofaris, George K.
Publicado 2021

Dopamine enhances willingness to exert effort for reward in Parkinson's disease

por Chong, Trevor T.-J., Bonnelle, Valerie, Manohar, Sanjay, Veromann, Kai-Riin, Muhammed, Kinan, Tofaris, George K., Hu, Michele, Husain, Masud
Publicado 2015

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

por Yan, Shijun, Jiang, Cheng, Janzen, Annette, Barber, Thomas R., Seger, Aline, Sommerauer, Michael, Davis, Jason J., Marek, Kenneth, Hu, Michele T., Oertel, Wolfgang H., Tofaris, George K.
Publicado 2023

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

por Davies, Sian E., Hallett, Penelope J., Moens, Thomas, Smith, Gaynor, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L., Liu, Ji-Long, Isacson, Ole, Tofaris, George K.
Publicado 2014

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

por Tanudjojo, Benedict, Shaikh, Samiha S., Fenyi, Alexis, Bousset, Luc, Agarwal, Devika, Marsh, Jade, Zois, Christos, Heman-Ackah, Sabrina, Fischer, Roman, Sims, David, Melki, Ronald, Tofaris, George K.
Publicado 2021

Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1

por Jonikas, Mindaugas, Madill, Martin, Mathy, Alexandre, Zekoll, Theresa, Zois, Christos E., Wigfield, Simon, Kurzawa‐Akanbi, Marzena, Browne, Cathy, Sims, David, Chinnery, Patrick F., Cowley, Sally A., Tofaris, George K.
Publicado 2018

Identification of distinct circulating exosomes in Parkinson's disease

por Tomlinson, Paul R, Zheng, Ying, Fischer, Roman, Heidasch, Ronny, Gardiner, Chris, Evetts, Samuel, Hu, Michele, Wade-Martins, Richard, Turner, Martin R, Morris, John, Talbot, Kevin, Kessler, Benedikt M, Tofaris, George K
Publicado 2015

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism

por Jiang, Cheng, Hopfner, Franziska, Katsikoudi, Antigoni, Hein, Robert, Catli, Candan, Evetts, Samuel, Huang, Yongzhi, Wang, Hong, Ryder, John W, Kuhlenbaeumer, Gregor, Deuschl, Guenther, Padovani, Alessandro, Berg, Daniela, Borroni, Barbara, Hu, Michele T, Davis, Jason J, Tofaris, George K
Publicado 2020

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

por Fernandes, Hugo J.R., Hartfield, Elizabeth M., Christian, Helen C., Emmanoulidou, Evangelia, Zheng, Ying, Booth, Heather, Bogetofte, Helle, Lang, Charmaine, Ryan, Brent J., Sardi, S. Pablo, Badger, Jennifer, Vowles, Jane, Evetts, Samuel, Tofaris, George K., Vekrellis, Kostas, Talbot, Kevin, Hu, Michele T., James, William, Cowley, Sally A., Wade-Martins, Richard
Publicado 2016

The Phenotypic Continuum of ATP1A3-Related Disorders

por Vezyroglou, Aikaterini, Akilapa, Rhoda, Barwick, Katy, Koene, Saskia, Brownstein, Catherine A., Holder-Espinasse, Muriel, Fry, Andrew E., Németh, Andrea H., Tofaris, George K., Hay, Eleanor, Hughes, Imelda, Mansour, Sahar, Mordekar, Santosh R., Splitt, Miranda, Turnpenny, Peter D., Demetriou, Demetria, Koopmann, Tamara T., Ruivenkamp, Claudia A.L., Agrawal, Pankaj B., Carr, Lucinda, Clowes, Virginia, Ghali, Neeti, Holder, Susan Elizabeth, Radley, Jessica, Male, Alison, Sisodiya, Sanjay M., Kurian, Manju A., Cross, J. Helen, Balasubramanian, Meena
Publicado 2022

Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis

por Dominik, Natalia, Magri, Stefania, Currò, Riccardo, Abati, Elena, Facchini, Stefano, Corbetta, Marinella, Macpherson, Hannah, Di Bella, Daniela, Sarto, Elisa, Stevanovski, Igor, Chintalaphani, Sanjog R, Akcimen, Fulya, Manini, Arianna, Vegezzi, Elisa, Quartesan, Ilaria, Montgomery, Kylie-Ann, Pirota, Valentina, Crespan, Emmanuele, Perini, Cecilia, Grupelli, Glenda Paola, Tomaselli, Pedro J, Marques, Wilson, Shaw, Joseph, Polke, James, Salsano, Ettore, Fenu, Silvia, Pareyson, Davide, Pisciotta, Chiara, Tofaris, George K, Nemeth, Andrea H, Ealing, John, Radunovic, Aleksandar, Kearney, Seamus, Kumar, Kishore R, Vucic, Steve, Kennerson, Marina, Reilly, Mary M, Houlden, Henry, Deveson, Ira, Tucci, Arianna, Taroni, Franco, Cortese, Andrea
Publicado 2023