Revisiting NTRKs as an emerging oncogene in hematological malignancies

por Joshi, Sunil K., Davare, Monika A., Druker, Brian J., Tognon, Cristina E.
Publicado 2019

Functional characterization of two rare BCR–FGFR1(+) leukemias

por Barnes, Evan J., Leonard, Jessica, Medeiros, Bruno C., Druker, Brian J., Tognon, Cristina E.
Publicado 2020

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients

por Rosenberg, Mara W., Watanabe-Smith, Kevin, Tyner, Jeffrey W., Tognon, Cristina E., Druker, Brian J., Borate, Uma
Publicado 2020

Durable Disease Control with MEK Inhibition in a Patient with NRAS-mutated Atypical Chronic Myeloid Leukemia

por Khanna, Vishesh, Pierce, Scott T, Dao, Kim-Hien T, Tognon, Cristina E, Hunt, David E, Junio, Brian, Tyner, Jeffrey W, Druker, Brian J
Publicado 2015

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

por Rozanov, Dmitri, Cheltsov, Anton, Nilsen, Aaron, Boniface, Christopher, Forquer, Isaac, Korkola, James, Gray, Joe, Tyner, Jeffrey, Tognon, Cristina E., Mills, Gordon B., Spellman, Paul
Publicado 2019

ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia

por Joshi, Sunil K., Keck, Jamie M., Eide, Christopher A., Bottomly, Daniel, Traer, Elie, Tyner, Jeffrey W., McWeeney, Shannon K., Tognon, Cristina E., Druker, Brian J.
Publicado 2020

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3 mutation-positive leukemia

por Agarwal, Anupriya, MacKenzie, Ryan J., Eide, Christopher A., Davare, Monika A., Watanabe-Smith, Kevin, Tognon, Cristina E., Mongoue-Tchokote, Solange, Park, Byung, Braziel, Rita M., Tyner, Jeffrey W., Druker, Brian J.
Publicado 2014

Evaluation of Differential Peptide Loading on Tandem Mass Tag-Based Proteomic and Phosphoproteomic Data Quality

por Sanford, James A., Wang, Yang, Hansen, Joshua R., Gritsenko, Marina A., Weitz, Karl K., Sagendorf, Tyler J., Tognon, Cristina E., Petyuk, Vladislav A., Qian, Wei-Jun, Liu, Tao, Druker, Brian J., Rodland, Karin D., Piehowski, Paul D.
Publicado 2021

Comprehensive molecular characterization of a rare case of Philadelphia chromosome–positive acute myeloid leukemia

por Rosenberg, Mara W., Savage, Samantha L., Eide, Christopher A., Reister Schultz, Anna, Cook, Rachel J., Press, Richard D., Rempfer, Carole, Eickelberg, Garrett, Wilmot, Beth, McWeeney, Shannon K., Tyner, Jeffrey W., Druker, Brian J., Tognon, Cristina E.
Publicado 2022

NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2(V617F)-positive myeloproliferative neoplasm cells

por Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A., Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Publicado 2020

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2(V617F)-positive myeloproliferative neoplasms

por de Melo Campos, Paula, Machado-Neto, João A., Eide, Christopher A., Savage, Samantha L., Scopim-Ribeiro, Renata, da Silva Souza Duarte, Adriana, Favaro, Patricia, Lorand-Metze, Irene, Costa, Fernando F., Tognon, Cristina E., Druker, Brian J., Saad, Sara T. Olalla, Traina, Fabiola
Publicado 2016

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

por Drusbosky, Leylah M., Vidva, Robinson, Gera, Saji, Lakshminarayana, Anjanasree V., Shyamasundar, Vijayashree P., Agrawal, Ashish Kumar, Talawdekar, Anay, Abbasi, Taher, Vali, Shireen, Tognon, Cristina E., Kurtz, Stephen E., Tyner, Jeffrey W., McWeeney, Shannon K., Druker, Brian J., Cogle, Christopher R.
Publicado 2019

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

por White, Brian S., Khan, Suleiman A., Mason, Mike J., Ammad-ud-din, Muhammad, Potdar, Swapnil, Malani, Disha, Kuusanmäki, Heikki, Druker, Brian J., Heckman, Caroline, Kallioniemi, Olli, Kurtz, Stephen E., Porkka, Kimmo, Tognon, Cristina E., Tyner, Jeffrey W., Aittokallio, Tero, Wennerberg, Krister, Guinney, Justin
Publicado 2021

Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms

por Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Scopim-Ribeiro, Renata, Eide, Christopher A., Coelho-Silva, Juan Luiz, Dechandt, Carlos Roberto Porto, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Scheucher, Priscila Santos, Simões, Belinda Pinto, Alberici, Luciane Carla, de Figueiredo Pontes, Lorena Lôbo, Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Traina, Fabiola
Publicado 2018

Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

por Lamble, Adam J., Kosaka, Yoko, Laderas, Ted, Maffit, Allie, Kaempf, Andy, Brady, Lauren K., Wang, Weiwei, Long, Nicola, Saultz, Jennifer N., Mori, Motomi, Soong, David, LeFave, Clare V., Huang, Fei, Adams, Homer, Loriaux, Marc M., Tognon, Cristina E., Lo, Pierrette, Tyner, Jeffrey W., Fan, Guang, McWeeney, Shannon K., Druker, Brian J., Lind, Evan F.
Publicado 2020

Functional Genomic Landscape of Acute Myeloid Leukemia

por Tyner, Jeffrey W., Tognon, Cristina E., Bottomly, Dan, Wilmot, Beth, Kurtz, Stephen E., Savage, Samantha L., Long, Nicola, Schultz, Anna Reister, Traer, Elie, Abel, Melissa, Agarwal, Anupriya, Blucher, Aurora, Borate, Uma, Bryant, Jade, Burke, Russell, Carlos, Amy, Carpenter, Richie, Carroll, Joseph, Chang, Bill, Coblentz, Cody, d’Almeida, Amanda, Cook, Rachel, Danilov, Alexey, Dao, Kim-Hien T., Degnin, Michie, Devine, Deirdre, Dibb, James, Edwards, David K., Eide, Chris A., English, Isabel, Glover, Jason, Henson, Rachel, Ho, Hibery, Jemal, Abdusebur, Johnson, Kara, Johnson, Ryan, Junio, Brian, Kaempf, Andy, Leonard, Jessica, Lin, Chenwei, Liu, Selina (Qiuying), Lo, Pierrette, Loriaux, Marc M., Luty, Samuel, Macey, Tara, MacManiman, Jason, Martinez, Jacqueline, Mori, Motomi, Nelson, Dylan, Nichols, Ceilidh, Peters, Jill, Ramsdill, Justin, Rofelty, Angela, Schuff, Robert, Searles, Robert, Segerdell, Erik, Smith, Rebecca L., Spurgeon, Stephen E., Sweeney, Tyler, Thapa, Aashis, Visser, Corinne, Wagner, Jake, Watanabe-Smith, Kevin, Werth, Kristen, Wolf, Joelle, White, Libbey, Yates, Amy, Zhang, Haijiao, Cogle, Christopher R., Collins, Robert H., Connolly, Denise C., Deininger, Michael W., Drusbosky, Leylah, Hourigan, Christopher S., Jordan, Craig T., Kropf, Patricia, Lin, Tara L., Martinez, Micaela E., Medeiros, Bruno C., Pallapati, Rachel R., Pollyea, Daniel A., Swords, Ronan T., Watts, Justin M., Weir, Scott J., Wiest, David L., Winters, Ryan M., McWeeney, Shannon K., Druker, Brian J.
Publicado 2018