DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

por Kondo, Naohide, Tohnai, Genki, Sahashi, Kentaro, Iida, Madoka, Kataoka, Mayumi, Nakatsuji, Hideaki, Tsutsumi, Yutaka, Hashizume, Atsushi, Adachi, Hiroaki, Koike, Haruki, Shinjo, Keiko, Kondo, Yutaka, Sobue, Gen, Katsuno, Masahisa
Publicado 2019

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

por Hirunagi, Tomoki, Sahashi, Kentaro, Tachikawa, Kiyoshi, Leu, Angel I., Nguyen, Michelle, Mukthavaram, Rajesh, Karmali, Priya P., Chivukula, Padmanabh, Tohnai, Genki, Iida, Madoka, Onodera, Kazunari, Ohyama, Manabu, Okada, Yohei, Okano, Hideyuki, Katsuno, Masahisa
Publicado 2021

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

por Iida, Madoka, Sahashi, Kentaro, Kondo, Naohide, Nakatsuji, Hideaki, Tohnai, Genki, Tsutsumi, Yutaka, Noda, Seiya, Murakami, Ayuka, Onodera, Kazunari, Okada, Yohei, Nakatochi, Masahiro, Tsukagoshi Okabe, Yuka, Shimizu, Shinobu, Mizuno, Masaaki, Adachi, Hiroaki, Okano, Hideyuki, Sobue, Gen, Katsuno, Masahisa
Publicado 2019

The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK

por Yokoi, Satoshi, Ito, Takuji, Sahashi, Kentaro, Nakatochi, Masahiro, Nakamura, Ryoichi, Tohnai, Genki, Fujioka, Yusuke, Ishigaki, Shinsuke, Udagawa, Tsuyoshi, Izumi, Yuishin, Morita, Mitsuya, Kano, Osamu, Oda, Masaya, Sone, Takefumi, Okano, Hideyuki, Atsuta, Naoki, Katsuno, Masahisa, Okada, Yohei, Sobue, Gen
Publicado 2022

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

por Nakamura, Ryoichi, Misawa, Kazuharu, Tohnai, Genki, Nakatochi, Masahiro, Furuhashi, Sho, Atsuta, Naoki, Hayashi, Naoki, Yokoi, Daichi, Watanabe, Hazuki, Watanabe, Hirohisa, Katsuno, Masahisa, Izumi, Yuishin, Kanai, Kazuaki, Hattori, Nobutaka, Morita, Mitsuya, Taniguchi, Akira, Kano, Osamu, Oda, Masaya, Shibuya, Kazumoto, Kuwabara, Satoshi, Suzuki, Naoki, Aoki, Masashi, Ohta, Yasuyuki, Yamashita, Toru, Abe, Koji, Hashimoto, Rina, Aiba, Ikuko, Okamoto, Koichi, Mizoguchi, Kouichi, Hasegawa, Kazuko, Okada, Yohei, Ishihara, Tomohiko, Onodera, Osamu, Nakashima, Kenji, Kaji, Ryuji, Kamatani, Yoichiro, Ikegawa, Shiro, Momozawa, Yukihide, Kubo, Michiaki, Ishida, Noriko, Minegishi, Naoko, Nagasaki, Masao, Sobue, Gen
Publicado 2020