Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentr...

por Sato, Sho, Matsumiya, Kota, Tohyama, Kimio, Kosugi, Yohei
Publicado 2021

Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

por Harada, Akina, Suzuki, Kazunori, Kamiguchi, Naomi, Miyamoto, Maki, Tohyama, Kimio, Nakashima, Kosuke, Taniguchi, Takahiko, Kimura, Haruhide
Publicado 2015

Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury

por Sisson, Thomas H., Christensen, Paul J., Muraki, Yo, Dils, Anthony J., Chibucos, Lauren, Subbotina, Natalya, Tohyama, Kimio, Horowitz, Jeffrey C., Matsuo, Takanori, Bailie, Marc, Nikam, Sham, Hazama, Masatoshi
Publicado 2018

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

por Sasaki, Masako, Miyahisa, Ikuo, Itono, Sachiko, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Ken‐ichi, Moritoh, Yusuke, Watanabe, Masanori, Tohyama, Kimio, Sasaki, Minoru, Sakamoto, Jun‐ichi, Kawamoto, Tomohiro
Publicado 2019

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obes...

por Ikeda, Zenichi, Kakegawa, Keiko, Kikuchi, Fumiaki, Itono, Sachiko, Oki, Hideyuki, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Kenichi, Watanabe, Masanori, Sasaki, Masako, Ishihara, Youko, Tohyama, Kimio, Kitazaki, Tomoyuki, Maekawa, Tsuyoshi, Sasaki, Minoru
Publicado 2022

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

por Ikeda, Zenichi, Kamei, Taku, Sasaki, Yusuke, Reynolds, Matthew, Sakai, Nozomu, Yoshikawa, Masato, Tawada, Michiko, Morishita, Nao, Dougan, Douglas R., Chen, Chien-Hung, Levin, Irena, Zou, Hua, Kuno, Masako, Arimura, Naoto, Kikukawa, Yusuke, Kondo, Mitsuyo, Tohyama, Kimio, Sato, Kenjiro
Publicado 2023