Turning the Tide Against Regulatory T Cells

por Han, SeongJun, Toker, Aras, Liu, Zhe Qi, Ohashi, Pamela S.
Publicado 2019

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

por Herppich, Susanne, Toker, Aras, Pietzsch, Beate, Kitagawa, Yohko, Ohkura, Naganari, Miyao, Takahisa, Floess, Stefan, Hori, Shohei, Sakaguchi, Shimon, Huehn, Jochen
Publicado 2019

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

por Muik, Alexander, Lui, Bonny Gaby, Bacher, Maren, Wallisch, Ann-Kathrin, Toker, Aras, Finlayson, Andrew, Krüger, Kimberly, Ozhelvaci, Orkun, Grikscheit, Katharina, Hoehl, Sebastian, Ciesek, Sandra, Türeci, Özlem, Sahin, Ugur
Publicado 2022

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells

por Garg, Garima, Nikolouli, Eirini, Hardtke-Wolenski, Matthias, Toker, Aras, Ohkura, Naganari, Beckstette, Michael, Miyao, Takahisa, Geffers, Robert, Floess, Stefan, Gerdes, Norbert, Lutgens, Esther, Osterloh, Anke, Hori, Shohei, Sakaguchi, Shimon, Jaeckel, Elmar, Huehn, Jochen
Publicado 2017

Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer

por MacGregor, Heather L., Garcia-Batres, Carlos, Sayad, Azin, Elia, Andrew, Berman, Hal K., Toker, Aras, Katz, Sarah Rachel, Shaw, Patricia A., Clarke, Blaise A., Crome, Sarah Q., Robert-Tissot, Celine, Bernardini, Marcus Q., Nguyen, Linh T., Ohashi, Pamela S.
Publicado 2019

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

por Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur
Publicado 2022

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

por Muik, Alexander, Adams, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria
Publicado 2022

Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice

por Muik, Alexander, Lui, Bonny Gaby, Bacher, Maren, Wallisch, Ann-Kathrin, Toker, Aras, Couto, Carla Iris Cadima, Güler, Alptekin, Mampilli, Veena, Schmitt, Geneva J., Mottl, Jonathan, Ziegenhals, Thomas, Fesser, Stephanie, Reinholz, Jonas, Wernig, Florian, Schraut, Karla-Gerlinde, Hefesha, Hossam, Cai, Hui, Yang, Qi, Walzer, Kerstin C., Grosser, Jessica, Strauss, Stefan, Finlayson, Andrew, Krüger, Kimberly, Ozhelvaci, Orkun, Grikscheit, Katharina, Kohmer, Niko, Ciesek, Sandra, Swanson, Kena A., Vogel, Annette B., Türeci, Özlem, Sahin, Ugur
Publicado 2022

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

por Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M., Alonso, Guzman, Rodriguez-Ruiz, Maria E., Schoedel, Kristina B., Blum, Jordan M., Sänger, Bianca, Salcedo, Theodora W., Burm, Saskia M., Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S., Toker, Aras, van den Brink, Edward N., Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C.W., Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio
Publicado 2022