Novel Scaffolds for Modulation of NOD2 Identified by Pharmacophore-Based Virtual Screening

por Guzelj, Samo, Tomašič, Tihomir, Jakopin, Žiga
Publicado 2022

In Silico Discovery and Optimisation of a Novel Structural Class of Hsp90 C-Terminal Domain Inhibitors

por Zajec, Živa, Dernovšek, Jaka, Gobec, Martina, Tomašič, Tihomir
Publicado 2022

Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K(V)10.1 Pore Blockers

por Toplak, Žan, Merzel, Franci, Pardo, Luis A., Peterlin Mašič, Lucija, Tomašič, Tihomir
Publicado 2021

Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

por Dernovšek, Jaka, Zajec, Živa, Durcik, Martina, Mašič, Lucija Peterlin, Gobec, Martina, Zidar, Nace, Tomašič, Tihomir
Publicado 2021

Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling

por Gramec Skledar, Darja, Trontelj, Jurij, Troberg, Johanna, Tomašič, Tihomir, Zega, Anamarija, Finel, Moshe, Peterlin Mašič, Lucija
Publicado 2018

Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

por Loi, Elena Maria, Weiss, Matjaž, Pajk, Stane, Gobec, Martina, Tomašič, Tihomir, Pieters, Roland J., Anderluh, Marko
Publicado 2020

Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors

por van Klaveren, Sjors, Dernovšek, Jaka, Jakopin, Žiga, Anderluh, Marko, Leffler, Hakon, Nilsson, Ulf J., Tomašič, Tihomir
Publicado 2022

Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery

por Durcik, Martina, Toplak, Žan, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin, Tomašič, Tihomir
Publicado 2020

Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations

por Tomašič, Tihomir, Durcik, Martina, Keegan, Bradley M., Skledar, Darja Gramec, Zajec, Živa, Blagg, Brian S. J., Bryant, Sharon D.
Publicado 2020

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

por Weiss, Matjaž, Loi, Elena M., Sterle, Maša, Balsollier, Cyril, Tomašič, Tihomir, Pieters, Roland J., Gobec, Martina, Anderluh, Marko
Publicado 2021

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores

por Tomašič, Tihomir, Zubrienė, Asta, Skok, Žiga, Martini, Riccardo, Pajk, Stane, Sosič, Izidor, Ilaš, Janez, Matulis, Daumantas, Bryant, Sharon D.
Publicado 2021

Catalytic Stereoconvergent Synthesis of Homochiral β-CF(3), β-SCF(3), and β-OCF(3) Benzylic Alcohols

por Cotman, Andrej Emanuel, Dub, Pavel A., Sterle, Maša, Lozinšek, Matic, Dernovšek, Jaka, Zajec, Živa, Zega, Anamarija, Tomašič, Tihomir, Cahard, Dominique
Publicado 2022

Discovery of K(V)1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

por Gubič, Špela, Hendrickx, Louise A., Toplak, Žan, Sterle, Maša, Peigneur, Steve, Tomašič, Tihomir, Pardo, Luis A., Tytgat, Jan, Zega, Anamarija, Mašič, Lucija P.
Publicado 2021

Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain

por Hassan, Mujtaba, Baussière, Floriane, Guzelj, Samo, Sundin, Anders P., Håkansson, Maria, Kovačič, Rebeka, Leffler, Hakon, Tomašič, Tihomir, Anderluh, Marko, Jakopin, Žiga, Nilsson, Ulf J.
Publicado 2021

Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening

por Loi, Elena M., Tomašič, Tihomir, Balsollier, Cyril, van Eekelen, Kevin, Weiss, Matjaž, Gobec, Martina, Alteen, Matthew G., Vocadlo, David J., Pieters, Roland J., Anderluh, Marko
Publicado 2022

New Diarylamine K(V)10.1 Inhibitors and Their Anticancer Potential

por Gubič, Špela, Toplak, Žan, Shi, Xiaoyi, Dernovšek, Jaka, Hendrickx, Louise Antonia, Pinheiro-Junior, Ernesto Lopes, Peigneur, Steve, Tytgat, Jan, Pardo, Luis A., Peterlin Mašič, Lucija, Tomašič, Tihomir
Publicado 2022

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

por Durcik, Martina, Skok, Žiga, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Szili, Petra Éva, Draskovits, Gábor, Révész, Tamás, Kikelj, Danijel, Nyerges, Akos, Pál, Csaba, Mašič, Lucija Peterlin, Tomašič, Tihomir
Publicado 2020

3D Pharmacophore-Based Discovery of Novel K(V)10.1 Inhibitors with Antiproliferative Activity

por Toplak, Žan, Hendrickx, Louise Antonia, Gubič, Špela, Možina, Štefan, Žegura, Bojana, Štern, Alja, Novak, Matjaž, Shi, Xiaoyi, Peigneur, Steve, Tytgat, Jan, Tomašič, Tihomir, Pardo, Luis A., Mašič, Lucija Peterlin
Publicado 2021

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

por Škedelj, Veronika, Arsovska, Emilija, Tomašić, Tihomir, Kroflič, Ana, Hodnik, Vesna, Hrast, Martina, Bešter-Rogač, Marija, Anderluh, Gregor, Gobec, Stanislav, Bostock, Julieanne, Chopra, Ian, O'Neill, Alex J., Randall, Christopher, Zega, Anamarija
Publicado 2012

Correction: Gubič et al. Design of New Potent and Selective Thiophene-Based K(V)1.3 Inhibitors and Their Potential for Anticancer Activity. Cancers 2022, 14, 2595

por Gubič, Špela, Hendrickx, Louise Antonia, Shi, Xiaoyi, Toplak, Žan, Možina, Štefan, Theemsche, Kenny M. Van, Pinheiro-Junior, Ernesto Lopes, Peigneur, Steve, Labro, Alain J., Pardo, Luis A., Tytgat, Jan, Tomašič, Tihomir, Peterlin Mašič, Lucija
Publicado 2023