Variation in responses to incretin therapy: Modifiable and non-modifiable factors

por Austin, Gregory O., Tomas, Alejandra
Publicado 2023

The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells

por Marzook, Amaara, Tomas, Alejandra, Jones, Ben
Publicado 2021

Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis

por Tomas, Alejandra, Futter, Clare, Moss, Stephen E.
Publicado 2004

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

por Rondas, Dieter, Tomas, Alejandra, Halban, Philippe A.
Publicado 2011

EGF receptor trafficking: consequences for signaling and cancer

por Tomas, Alejandra, Futter, Clare E., Eden, Emily R.
Publicado 2014

Moesin and cortactin control actin-dependent multivesicular endosome biogenesis

por Muriel, Olivia, Tomas, Alejandra, Scott, Cameron C., Gruenberg, Jean
Publicado 2016

Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation

por Tomas, Alejandra, Jones, Sylwia, Vaughan, Simon O., Hochhauser, Daniel, Futter, Clare E.
Publicado 2017

Potent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor

por Jones, Ben J., Scopelliti, Rosario, Tomas, Alejandra, Bloom, Stephen R., Hodson, David J., Broichhagen, Johannes
Publicado 2017

Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

por Manchanda, Yusman, Bitsi, Stavroula, Chen, Shiqian, Broichhagen, Johannes, Bernardino de la Serna, Jorge, Jones, Ben, Tomas, Alejandra
Publicado 2023

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

por Tomas, Alejandra, Vaughan, Simon O., Burgoyne, Thomas, Sorkin, Alexander, Hartley, John A., Hochhauser, Daniel, Futter, Clare E.
Publicado 2015

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

por Marzban, Lucy, Tomas, Alejandra, Becker, Thomas C., Rosenberg, Lawrence, Oberholzer, Jose, Fraser, Paul E., Halban, Philippe A., Verchere, C. Bruce
Publicado 2008

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Di...

por Marzban, Lucy, Tomas, Alejandra, Becker, Thomas C., Rosenberg, Lawrence, Oberholzer, Jose, Fraser, Paul E., Halban, Philippe A., Verchere, C. Bruce
Publicado 2016

GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo

por Arcones, Alba C., Vila-Bedmar, Rocío, Mirasierra, Mercedes, Cruces-Sande, Marta, Vallejo, Mario, Jones, Ben, Tomas, Alejandra, Mayor, Federico, Murga, Cristina
Publicado 2021

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

por McGlone, Emma Rose, Manchanda, Yusman, Jones, Ben, Pickford, Phil, Inoue, Asuka, Carling, David, Bloom, Stephen R., Tan, Tricia, Tomas, Alejandra
Publicado 2021

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

por Lucey, Maria, Pickford, Philip, Bitsi, Stavroula, Minnion, James, Ungewiss, Jan, Schoeneberg, Katja, Rutter, Guy A., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Publicado 2020

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

por Solomou, Antonia, Meur, Gargi, Bellomo, Elisa, Hodson, David J., Tomas, Alejandra, Migrenne Li, Stéphanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, Rutter, Guy A.
Publicado 2015

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice

por Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra
Publicado 2023

Hepatocyte cholesterol content modulates glucagon receptor signalling

por McGlone, Emma Rose, Ansell, T. Bertie, Dunsterville, Cecilia, Song, Wanling, Carling, David, Tomas, Alejandra, Bloom, Stephen R., Sansom, Mark S.P., Tan, Tricia, Jones, Ben
Publicado 2022

Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

por Fremaux, Juliette, Venin, Claire, Mauran, Laura, Zimmer, Robert, Koensgen, Florian, Rognan, Didier, Bitsi, Stavroula, Lucey, Maria A., Jones, Ben, Tomas, Alejandra, Guichard, Gilles, Goudreau, Sébastien R.
Publicado 2019

Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

por Watson, Samuel A., Duff, James, Bardi, Ifigeneia, Zabielska, Magdalena, Atanur, Santosh S., Jabbour, Richard J., Simon, André, Tomas, Alejandra, Smolenski, Ryszard T., Harding, Sian E., Perbellini, Filippo, Terracciano, Cesare M.
Publicado 2019