ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIα

por Dong, Zhiwan, Tomkinson, Alan E.
Publicado 2006

Translocation of XRCC1 and DNA ligase IIIα from centrosomes to chromosomes in response to DNA damage in mitotic human cells

por Okano, Satoshi, Lan, Li, Tomkinson, Alan E., Yasui, Akira
Publicado 2005

NAD(+) is not utilized as a co-factor for DNA ligation by human DNA ligase IV

por Zhao, Bailin, Naila, Tasmin, Lieber, Michael R, Tomkinson, Alan E
Publicado 2020

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions

por Bilkis, Rabeya, Lake, Robert J, Cooper, Karen L, Tomkinson, Alan, Fan, Hua-Ying
Publicado 2023

Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells

por Matsumoto, Yoshihiro, Rodriguez, Victoria, Whitford, Tracy A., Beeharry, Neil, Ide, Hiroshi, Tomkinson, Alan E.
Publicado 2015

The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast

por Wiest, Nathaniel E., Houghtaling, Scott, Sanchez, Joseph C., Tomkinson, Alan E., Osley, Mary Ann
Publicado 2017

Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining

por Kukshal, Vandna, Kim, In-Kwon, Hura, Gregory L., Tomkinson, Alan E., Tainer, John A., Ellenberger, Tom
Publicado 2015

Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1

por Bhandari, Seema Khattri, Wiest, Nathaniel, Sallmyr, Annahita, Du, Ruofei, Ferry, Laure, Defossez, Pierre-Antoine, Tomkinson, Alan E.
Publicado 2023

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase

por Vijayakumar, Sangeetha, Chapados, Brian R., Schmidt, Kristina H., Kolodner, Richard D., Tainer, John A., Tomkinson, Alan E.
Publicado 2007

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

por Rashid, Ishtiaque, Hammel, Michal, Sverzhinsky, Aleksandr, Tsai, Miaw-Sheue, Pascal, John M., Tainer, John A., Tomkinson, Alan E.
Publicado 2021

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ

por Chen, Siyu, Vogt, Alex, Lee, Linda, Naila, Tasmin, McKeown, Ryan, Tomkinson, Alan E, Lees-Miller, Susan P, He, Yuan
Publicado 2023

Replication protein A safeguards genome integrity by controlling NER incision events

por Overmeer, René M., Moser, Jill, Volker, Marcel, Kool, Hanneke, Tomkinson, Alan E., van Zeeland, Albert A., Mullenders, Leon H.F., Fousteri, Maria
Publicado 2011

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

por Hammel, Michal, Rashid, Ishtiaque, Sverzhinsky, Aleksandr, Pourfarjam, Yasin, Tsai, Miaw-Sheue, Ellenberger, Tom, Pascal, John M, Kim, In-Kwon, Tainer, John A, Tomkinson, Alan E
Publicado 2020

Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

por Berquist, Brian R., Singh, Dharmendra Kumar, Fan, Jinshui, Kim, Daemyung, Gillenwater, Elizabeth, Kulkarni, Avanti, Bohr, Vilhelm A., Ackerman, Eric J., Tomkinson, Alan E., Wilson, David M.
Publicado 2010

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

por Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Vandoorne, Tijs, Eckelmann, Bradley J., Mitra, Sankar, Tomkinson, Alan E., Van Den Bosch, Ludo, Hegde, Muralidhar L.
Publicado 2018

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells

por Eckelmann, Bradley J, Bacolla, Albino, Wang, Haibo, Ye, Zu, Guerrero, Erika N, Jiang, Wei, El-Zein, Randa, Hegde, Muralidhar L, Tomkinson, Alan E, Tainer, John A, Mitra, Sankar
Publicado 2020

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

por Hammel, Michal, Yu, Yaping, Radhakrishnan, Sarvan K., Chokshi, Chirayu, Tsai, Miaw-Sheue, Matsumoto, Yoshihiro, Kuzdovich, Monica, Remesh, Soumya G., Fang, Shujuan, Tomkinson, Alan E., Lees-Miller, Susan P., Tainer, John A.
Publicado 2016

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

por Ali, Reem, Alabdullah, Muslim, Algethami, Mashael, Alblihy, Adel, Miligy, Islam, Shoqafi, Ahmed, Mesquita, Katia A., Abdel-Fatah, Tarek, Chan, Stephen YT, Chiang, Pei Wen, Mongan, Nigel P, Rakha, Emad A, Tomkinson, Alan E, Madhusudan, Srinivasan
Publicado 2021

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration

por Kodavati, Manohar, Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Provasek, Vincent, Maloji Rao, Vikas H, Vedula, Indira, Zhang, Aijun, Mitra, Sankar, Tomkinson, Alan E., Hamilton, Dale J., Bosch, Ludo Van Den, Hegde, Muralidhar L.
Publicado 2023