The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins

por Salaun, Christine, Tomkinson, Nicholas C.O., Chamberlain, Luke H.
Publicado 2023

The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation

por Salaun, Christine, Greaves, Jennifer, Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Publicado 2020

Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2

por Locatelli, Carolina, Lemonidis, Kimon, Salaun, Christine, Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Publicado 2020

A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis

por Diez-Ardanuy, Cinta, Greaves, Jennifer, Munro, Kevin R., Tomkinson, Nicholas C. O., Chamberlain, Luke H.
Publicado 2017

Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system

por Tipping, William J., Merchant, Andrew S., Fearon, Rebecca, Tomkinson, Nicholas C. O., Faulds, Karen, Graham, Duncan
Publicado 2022

Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides

por Curle, Jonathan M., Perieteanu, Marina C., Humphreys, Philip G., Kennedy, Alan R., Tomkinson, Nicholas C. O.
Publicado 2020

Metal Triflate-Promoted Allylic Substitution Reactions of Cinnamyl Alcohol in the Presence of Orthoesters and Acetals

por Chaffey, Dawn R., Alamillo-Ferrer, Carla, Davies, Thomas E., Taylor, Stuart H., Tomkinson, Nicholas C. O., Graham, Andrew E.
Publicado 2019

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme–substrate interaction

por Butler, Liam, Locatelli, Carolina, Allagioti, Despoina, Lousa, Irina, Lemonidis, Kimon, Tomkinson, Nicholas C.O., Salaun, Christine, Chamberlain, Luke H.
Publicado 2022

Determination of Intracellular Esterase Activity Using Ratiometric Raman Sensing and Spectral Phasor Analysis

por Braddick, Henry J., Tipping, William J., Wilson, Liam T., Jaconelli, Harry S., Grant, Emma K., Faulds, Karen, Graham, Duncan, Tomkinson, Nicholas C. O.
Publicado 2023

Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug–cell interactions

por Tipping, William J., Wilson, Liam T., An, Connie, Leventi, Aristea A., Wark, Alastair W., Wetherill, Corinna, Tomkinson, Nicholas C. O., Faulds, Karen, Graham, Duncan
Publicado 2022

Covalent targeting of non-cysteine residues in PI4KIIIβ

por Cosgrove, Brett, Grant, Emma K., Bertrand, Sophie, Down, Kenneth D., Somers, Don O., P. Evans, John, Tomkinson, Nicholas C. O., Barker, Michael D.
Publicado 2023

Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy

por Jamieson, Lauren E., Greaves, Jennifer, McLellan, Jayde A., Munro, Kevin R., Tomkinson, Nicholas C.O., Chamberlain, Luke H., Faulds, Karen, Graham, Duncan
Publicado 2018

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

por Salaun, Christine, Takizawa, Hiroya, Galindo, Alex, Munro, Kevin R., McLellan, Jayde, Sugimoto, Isamu, Okino, Tomotaka, Tomkinson, Nicholas C.O., Chamberlain, Luke H.
Publicado 2022

Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry

por Thomas, Ross P., Grant, Emma K., Dickinson, Eleanor R., Zappacosta, Francesca, Edwards, Lee J., Hann, Michael M., House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Publicado 2023

A direct-to-biology high-throughput chemistry approach to reactive fragment screening

por Thomas, Ross P., Heap, Rachel E., Zappacosta, Francesca, Grant, Emma K., Pogány, Peter, Besley, Stephen, Fallon, David J., Hann, Michael M., House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Publicado 2021

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments

por Aatkar, Arron, Vuorinen, Aini, Longfield, Oliver E., Gilbert, Katharine, Peltier-Heap, Rachel, Wagner, Craig D., Zappacosta, Francesca, Rittinger, Katrin, Chung, Chun-wa, House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Publicado 2023

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

por Pariollaud, Marie, Gibbs, Julie E., Hopwood, Thomas W., Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D. Heulyn, Tellam, James P., Bresciani, Stefano, Tomkinson, Nicholas C.O., Wojno-Picon, Justyna, Cooper, Anthony W.J., Daniels, Dion A., Trump, Ryan P., Grant, Daniel, Zuercher, William, Willson, Timothy M., MacDonald, Andrew S., Bolognese, Brian, Podolin, Patricia L., Sanchez, Yolanda, Loudon, Andrew S.I., Ray, David W.
Publicado 2018