Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy

por Jiang, Xiaowei, Tomlinson, Ian P. M.
Publicado 2020

Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer

por Cornish, Alex J., Tomlinson, Ian P.M., Houlston, Richard S.
Publicado 2019

The effects of mutational processes and selection on driver mutations across cancer types

por Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.
Publicado 2018

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types

por Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.
Publicado 2020

What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data?

por Willis, Lisa, Graham, Trevor A., Alarcón, Tomás, Alison, Malcolm R., Tomlinson, Ian P. M., Page, Karen M.
Publicado 2013

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

por Mäkinen, Netta, Heinonen, Hanna-Riikka, Moore, Shane, Tomlinson, Ian P.M., van der Spuy, Zephne M., Aaltonen, Lauri A.
Publicado 2011

Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer

por Beggs, Andrew D., Dilworth, Mark P., Domingo, Enric, Midgley, Rachel, Kerr, David, Tomlinson, Ian P.M., Middleton, Gary W.
Publicado 2015

Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation

por Beggs, Andrew D., Jones, Angela, Shepherd, Neil, Arnaout, Abed, Finlayson, Caroline, Abulafi, A. Muti, Morton, Dion G., Matthews, Glenn M., Hodgson, Shirley V., Tomlinson, Ian P. M.
Publicado 2013

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank

por Zhang, Xiaomeng, Li, Xue, He, Yazhou, Law, Philip J., Farrington, Susan M., Campbell, Harry, Tomlinson, Ian P. M., Houlston, Richard S., Dunlop, Malcolm G., Timofeeva, Maria, Theodoratou, Evropi
Publicado 2021

The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer

por Elsaba, Tarek M. A., Martinez-Pomares, Luisa, Robins, Adrian R., Crook, Simon, Seth, Rashmi, Jackson, Darryl, McCart, Amy, Silver, Andrew R., Tomlinson, Ian P. M., Ilyas, Mohammad
Publicado 2010

Genomic Evolution and Transcriptional Changes in the Evolution of Prostate Cancer into Neuroendocrine and Ductal Carcinoma Types

por Rao, Srinivasa R., Protheroe, Andrew, Cerundolo, Lucia, Maldonado-Perez, David, Browning, Lisa, Lamb, Alastair D., Bryant, Richard J., Mills, Ian G., Woodcock, Dan J., Hamdy, Freddie C., Tomlinson, Ian P. M., Verrill, Clare
Publicado 2023

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

por Church, David N., Briggs, Sarah E.W., Palles, Claire, Domingo, Enric, Kearsey, Stephen J., Grimes, Jonathon M., Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M., Hodgson, Shirley V., Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P.M.
Publicado 2013

Measuring single cell divisions in human tissues from multi-region sequencing data

por Werner, Benjamin, Case, Jack, Williams, Marc J., Chkhaidze, Ketevan, Temko, Daniel, Fernández-Mateos, Javier, Cresswell, George D., Nichol, Daniel, Cross, William, Spiteri, Inmaculada, Huang, Weini, Tomlinson, Ian P. M., Barnes, Chris P., Graham, Trevor A., Sottoriva, Andrea
Publicado 2020

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

por Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M
Publicado 2013

Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study

por Zhang, Xiaomeng, Theodoratou, Evropi, Li, Xue, Farrington, Susan M., Law, Philip J., Broderick, Peter, Walker, Marion, Klimentidis, Yann C., Rees, Jessica M. B., Houlston, Richard S., Tomlinson, Ian P. M., Burgess, Stephen, Campbell, Harry, Dunlop, Malcolm G., Timofeeva, Maria
Publicado 2021

Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer

por Church, David N., Stelloo, Ellen, Nout, Remi A., Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P. M., Wild, Peter J., Lambrechts, Diether, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Bosse, Tjalling
Publicado 2014

Evolutionary history of human colitis-associated colorectal cancer

por Baker, Ann-Marie, Cross, William, Curtius, Kit, Al Bakir, Ibrahim, Choi, Chang-Ho Ryan, Davis, Hayley Louise, Temko, Daniel, Biswas, Sujata, Martinez, Pierre, Williams, Marc J, Lindsay, James O, Feakins, Roger, Vega, Roser, Hayes, Stephen J, Tomlinson, Ian P M, McDonald, Stuart A C, Moorghen, Morgan, Silver, Andrew, East, James E, Wright, Nicholas A, Wang, Lai Mun, Rodriguez-Justo, Manuel, Jansen, Marnix, Hart, Ailsa L, Leedham, Simon J, Graham, Trevor A
Publicado 2019

Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

por Spain, Sarah L., Carvajal-Carmona, Luis G., Howarth, Kimberley M., Jones, Angela M., Su, Zhan, Cazier, Jean-Baptiste, Williams, Jennet, Aaltonen, Lauri A., Pharoah, Paul, Kerr, David J., Cheadle, Jeremy, Li, Li, Casey, Graham, Vodicka, Pavel, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Morreau, Hans, van Wezel, Tom, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellvi-Bel, Sergi, Dunlop, Malcolm, Houlston, Richard S., Tomlinson, Ian P.M.
Publicado 2012

Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies

por Elliott, Katherine S., Zeggini, Eleftheria, McCarthy, Mark I., Gudmundsson, Julius, Sulem, Patrick, Stacey, Simon N., Thorlacius, Steinunn, Amundadottir, Laufey, Grönberg, Henrik, Xu, Jianfeng, Gaborieau, Valerie, Eeles, Rosalind A., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Muir, Kenneth, Hwang, Shih-Jen, Spitz, Margaret R., Zanke, Brent, Carvajal-Carmona, Luis, Brown, Kevin M., Hayward, Nicholas K., Macgregor, Stuart, Tomlinson, Ian P. M., Lemire, Mathieu, Amos, Christopher I., Murabito, Joanne M., Isaacs, William B., Easton, Douglas F., Brennan, Paul, Barkardottir, Rosa B., Gudbjartsson, Daniel F., Rafnar, Thorunn, Hunter, David J., Chanock, Stephen J., Stefansson, Kari, Ioannidis, John P. A.
Publicado 2010

A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection

por Reijns, Martin A. M., Thompson, Louise, Acosta, Juan Carlos, Black, Holly A., Sanchez-Luque, Francisco J., Diamond, Austin, Parry, David A., Daniels, Alison, O'Shea, Marie, Uggenti, Carolina, Sanchez, Maria C., O'Callaghan, Alan, McNab, Michelle L. L., Adamowicz, Martyna, Friman, Elias T., Hurd, Toby, Jarman, Edward J., Chee, Frederic Li Mow, Rainger, Jacqueline K., Walker, Marion, Drake, Camilla, Longman, Dasa, Mordstein, Christine, Warlow, Sophie J., McKay, Stewart, Slater, Louise, Ansari, Morad, Tomlinson, Ian P. M., Moore, David, Wilkinson, Nadine, Shepherd, Jill, Templeton, Kate, Johannessen, Ingolfur, Tait-Burkard, Christine, Haas, Jürgen G., Gilbert, Nick, Adams, Ian R., Jackson, Andrew P.
Publicado 2020