Connexin Lateralization Contributes to Male Susceptibility to Atrial Fibrillation

por Thibault, Simon, Ton, Anh-Tuan, Huynh, François, Fiset, Céline
Publicado 2022

Targeting SARS-CoV-2 papain-like protease in the postvaccine era

por Ton, Anh-Tien, Pandey, Mohit, Smith, Jason R., Ban, Fuqiang, Fernandez, Michael, Cherkasov, Artem
Publicado 2022

Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer

por Ton, Anh-Tien, Singh, Kriti, Morin, Hélène, Ban, Fuqiang, Leblanc, Eric, Lee, Joseph, Lallous, Nada, Cherkasov, Artem
Publicado 2020

Atrial Electrical Remodeling in Mice With Cardiac‐Specific Overexpression of Angiotensin II Type 1 Receptor

por Demers, Julie, Ton, Anh‐Tuan, Huynh, François, Thibault, Simon, Ducharme, Anique, Paradis, Pierre, Nemer, Mona, Fiset, Céline
Publicado 2022

Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery

por Gentile, Francesco, Agrawal, Vibudh, Hsing, Michael, Ton, Anh-Tien, Ban, Fuqiang, Norinder, Ulf, Gleave, Martin E., Cherkasov, Artem
Publicado 2020

Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons

por Tiwari, Manindra Nath, Hall, Bradford E, Ton, Anh-Tuan, Ghetti, Re, Terse, Anita, Amin, Niranjana, Chung, Man-Kyo, Kulkarni, Ashok B
Publicado 2023

Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer

por Ton, Anh-Tien, Foo, Jane, Singh, Kriti, Lee, Joseph, Kalyta, Anastasia, Morin, Helene, Perez, Carl, Ban, Fuqiang, Leblanc, Eric, Lallous, Nada, Cherkasov, Artem
Publicado 2022

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

por Lee, Jaeyong, Kenward, Calem, Worrall, Liam J., Vuckovic, Marija, Gentile, Francesco, Ton, Anh-Tien, Ng, Myles, Cherkasov, Artem, Strynadka, Natalie C. J., Paetzel, Mark
Publicado 2022

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

por Lee, Jaeyong, Worrall, Liam J., Vuckovic, Marija, Rosell, Federico I., Gentile, Francesco, Ton, Anh-Tien, Caveney, Nathanael A., Ban, Fuqiang, Cherkasov, Artem, Paetzel, Mark, Strynadka, Natalie C. J.
Publicado 2020

Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules

por Gentile, Francesco, Fernandez, Michael, Ban, Fuqiang, Ton, Anh-Tien, Mslati, Hazem, Perez, Carl F., Leblanc, Eric, Yaacoub, Jean Charle, Gleave, James, Stern, Abraham, Wong, Bill, Jean, François, Strynadka, Natalie, Cherkasov, Artem
Publicado 2021

Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart

por Ton, Anh Tuan, Nguyen, William, Sweat, Katrina, Miron, Yannick, Hernandez, Eduardo, Wong, Tiara, Geft, Valentyna, Macias, Andrew, Espinoza, Ana, Truong, Ky, Rasoul, Lana, Stafford, Alexa, Cotta, Tamara, Mai, Christina, Indersmitten, Tim, Page, Guy, Miller, Paul E., Ghetti, Andre, Abi-Gerges, Najah
Publicado 2021

Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain

por Nguyen, Phuong T, Nguyen, Hai M, Wagner, Karen M, Stewart, Robert G, Singh, Vikrant, Thapa, Parashar, Chen, Yi-Je, Lillya, Mark W, Ton, Anh Tuan, Kondo, Richard, Ghetti, Andre, Pennington, Michael W, Hammock, Bruce, Griffith, Theanne N, Sack, Jon T, Wulff, Heike, Yarov-Yarovoy, Vladimir
Publicado 2022

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants

por Pérez-Vargas, Jimena, Worrall, Liam J., Olmstead, Andrea D., Ton, Anh-Tien, Lee, Jaeyong, Villanueva, Ivan, Thompson, Connor A. H., Dudek, Svenja, Ennis, Siobhan, Smith, Jason R., Shapira, Tirosh, De Guzman, Joshua, Gang, Shutong, Ban, Fuqiang, Vuckovic, Marija, Bielecki, Michael, Kovacic, Suzana, Kenward, Calem, Hong, Christopher Yee, Gordon, Danielle G., Levett, Paul N., Krajden, Mel, Leduc, Richard, Boudreault, Pierre-Luc, Niikura, Masahiro, Paetzel, Mark, Young, Robert N., Cherkasov, Artem, Strynadka, Natalie C. J., Jean, François
Publicado 2023

Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response

por Dragomir, Mihnea P., Fuentes-Mattei, Enrique, Winkle, Melanie, Okubo, Keishi, Bayraktar, Recep, Knutsen, Erik, Qdaisat, Aiham, Chen, Meng, Li, Yongfeng, Shimizu, Masayoshi, Pang, Lan, Liu, Kevin, Liu, Xiuping, Anfossi, Simone, Zhang, Huanyu, Koch, Ines, Tran, Anh M., Mohapatra, Swati, Ton, Anh, Kaplan, Mecit, Anderson, Matthew W., Rothfuss, Spencer J., Silasi, Robert, Keshari, Ravi S., Ferracin, Manuela, Ivan, Cristina, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Georgescu, Constantin, Banerjee, Pinaki P., Basar, Rafet, Li, Ziyi, Horst, David, Vasilescu, Catalin, Bertilaccio, Maria Teresa S., Rezvani, Katayoun, Lupu, Florea, Yeung, Sai-Ching, Calin, George A.
Publicado 2023