A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

por Hannaford, Matthew, Loyer, Nicolas, Tonelli, Francesca, Zoltner, Martin, Januschke, Jens
Publicado 2019

Knocking out TMEM38B in human foetal osteoblasts hFOB 1.19 by CRISPR/Cas9: A model for recessive OI type XIV

por Leoni, Laura, Tonelli, Francesca, Besio, Roberta, Gioia, Roberta, Moccia, Francesco, Rossi, Antonio, Forlino, Antonella
Publicado 2021

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

por Nirujogi, Raja S., Tonelli, Francesca, Taylor, Matthew, Lis, Pawel, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Publicado 2021

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

por Dhekne, Herschel S, Yanatori, Izumi, Vides, Edmundo G, Sobu, Yuriko, Diez, Federico, Tonelli, Francesca, Pfeffer, Suzanne R
Publicado 2021

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

por Khan, Shahzad S, Sobu, Yuriko, Dhekne, Herschel S, Tonelli, Francesca, Berndsen, Kerryn, Alessi, Dario R, Pfeffer, Suzanne R
Publicado 2021

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

por Tonelli, Francesca, Alossaimi, Manal, Natarajan, Viswanathan, Gorshkova, Irina, Berdyshev, Evgeny, Bittman, Robert, Watson, David G., Pyne, Susan, Pyne, Nigel J
Publicado 2013

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-inde...

por Tonelli, Francesca, Lim, Keng Gat, Loveridge, Carolyn, Long, Jaclyn, Pitson, Stuart M., Tigyi, Gabor, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Publicado 2010

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

por Dhekne, Herschel S, Yanatori, Izumi, Gomez, Rachel C, Tonelli, Francesca, Diez, Federico, Schüle, Birgitt, Steger, Martin, Alessi, Dario R, Pfeffer, Suzanne R
Publicado 2018

Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders

por Tonelli, Francesca, Bek, Jan Willem, Besio, Roberta, De Clercq, Adelbert, Leoni, Laura, Salmon, Phil, Coucke, Paul J., Willaert, Andy, Forlino, Antonella
Publicado 2020

Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease

por Karayel, Özge, Tonelli, Francesca, Virreira Winter, Sebastian, Geyer, Phillip E., Fan, Ying, Sammler, Esther M., Alessi, Dario R., Steger, Martin, Mann, Matthias
Publicado 2020

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

por Kalogeropulou, Alexia F., Purlyte, Elena, Tonelli, Francesca, Lange, Sven M., Wightman, Melanie, Prescott, Alan R., Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R.
Publicado 2022

Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta

por Forte-Gomez, Helena Fabiana, Gioia, Roberta, Tonelli, Francesca, Kobbe, Birgit, Koch, Peter, Bloch, Wilhelm, Paulsson, Mats, Zaucke, Frank, Forlino, Antonella, Wagener, Raimund
Publicado 2022

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase

por Purlyte, Elena, Dhekne, Herschel S, Sarhan, Adil R, Gomez, Rachel, Lis, Pawel, Wightman, Melanie, Martinez, Terina N, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R
Publicado 2017

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

por Steger, Martin, Diez, Federico, Dhekne, Herschel S, Lis, Pawel, Nirujogi, Raja S, Karayel, Ozge, Tonelli, Francesca, Martinez, Terina N, Lorentzen, Esben, Pfeffer, Suzanne R, Alessi, Dario R, Mann, Matthias
Publicado 2017

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

por Berndsen, Kerryn, Lis, Pawel, Yeshaw, Wondwossen M, Wawro, Paulina S, Nirujogi, Raja S, Wightman, Melanie, Macartney, Thomas, Dorward, Mark, Knebel, Axel, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R
Publicado 2019

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

por Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A.S., Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D., Alessi, Dario R.
Publicado 2016

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

por Gioia, Roberta, Tonelli, Francesca, Ceppi, Ilaria, Biggiogera, Marco, Leikin, Sergey, Fisher, Shannon, Tenedini, Elena, Yorgan, Timur A., Schinke, Thorsten, Tian, Kun, Schwartz, Jean-Marc, Forte, Fabiana, Wagener, Raimund, Villani, Simona, Rossi, Antonio, Forlino, Antonella
Publicado 2017

Zebrafish Tric-b is required for skeletal development and bone cells differentiation

por Tonelli, Francesca, Leoni, Laura, Daponte, Valentina, Gioia, Roberta, Cotti, Silvia, Fiedler, Imke A. K., Larianova, Daria, Willaert, Andy, Coucke, Paul J., Villani, Simona, Busse, Björn, Besio, Roberta, Rossi, Antonio, Witten, P. Eckhard, Forlino, Antonella
Publicado 2023

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

por Mir, Rafeeq, Tonelli, Francesca, Lis, Pawel, Macartney, Thomas, Polinski, Nicole K., Martinez, Terina N., Chou, Meng-Yun, Howden, Andrew J.M., König, Theresa, Hotzy, Christoph, Milenkovic, Ivan, Brücke, Thomas, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R.
Publicado 2018

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

por Lis, Pawel, Burel, Sophie, Steger, Martin, Mann, Matthias, Brown, Fiona, Diez, Federico, Tonelli, Francesca, Holton, Janice L., Ho, Philip Winglok, Ho, Shu-Leong, Chou, Meng-Yun, Polinski, Nicole K., Martinez, Terina N., Davies, Paul, Alessi, Dario R.
Publicado 2018