Drug–Target Kinetics in Drug Discovery

por Tonge, Peter J.
Publicado 2017

Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis

por Tonge, Peter J.
Publicado 2019

Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics

por Evans, Christopher E., Matarlo, Joe S., Tonge, Peter J., Tan, Derek S.
Publicado 2016

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

por Kinnings, Sarah L., Liu, Nina, Buchmeier, Nancy, Tonge, Peter J., Xie, Lei, Bourne, Philip E.
Publicado 2009

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

por Daryaee, Fereidoon, Zhang, Zhuo, Gogarty, Kayla R., Li, Yong, Merino, Jonathan, Fisher, Stewart L., Tonge, Peter J.
Publicado 2017

Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE

por Evans, Christopher E., Si, Yuanyuan, Matarlo, Joe S., Yin, Yue, French, Jarrod B., Tonge, Peter J., Tan, Derek S.
Publicado 2019

Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants**

por Laptenok, Sergey P, Lukacs, Andras, Gil, Agnieszka, Brust, Richard, Sazanovich, Igor V, Greetham, Gregory M, Tonge, Peter J, Meech, Stephen R
Publicado 2015

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

por Li, Huei-Jiun, Lai, Cheng-Tsung, Pan, Pan, Yu, Weixuan, Liu, Nina, Bommineni, Gopal R., Garcia-Diaz, Miguel, Simmerling, Carlos, Tonge, Peter J.
Publicado 2014

Proteins in Action: Femtosecond to Millisecond Structural Dynamics of a Photoactive Flavoprotein

por Brust, Richard, Lukacs, Andras, Haigney, Allison, Addison, Kiri, Gil, Agnieszka, Towrie, Michael, Clark, Ian P., Greetham, Gregory M., Tonge, Peter J., Meech, Stephen R.
Publicado 2013

BLUF Domain Function Does Not Require a Metastable Radical Intermediate State

por Lukacs, Andras, Brust, Richard, Haigney, Allison, Laptenok, Sergey P., Addison, Kiri, Gil, Agnieszka, Towrie, Michael, Greetham, Gregory M., Tonge, Peter J., Meech, Stephen R.
Publicado 2014

Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase

por Daryaee, Fereidoon, Chang, Andrew, Schiebel, Johannes, Lu, Yang, Zhang, Zhuo, Kapilashrami, Kanishk, Walker, Stephen G., Kisker, Caroline, Sotriffer, Christoph A., Fisher, Stewart L., Tonge, Peter J.
Publicado 2016

The biodistribution of 5-[(18)F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography

por Zhang, Zhuo, Ordonez, Alvaro A., Smith-Jones, Peter, Wang, Hui, Gogarty, Kayla R., Daryaee, Fereidoon, Bambarger, Lauren E., Chang, Yong S., Jain, Sanjay K., Tonge, Peter J.
Publicado 2017

Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis

por Tolentino Collado, Jinnette, Iuliano, James N., Pirisi, Katalin, Jewlikar, Samruddhi, Adamczyk, Katrin, Greetham, Gregory M., Towrie, Michael, Tame, Jeremy R. H., Meech, Stephen R., Tonge, Peter J., Lukacs, Andras
Publicado 2022

Photocycle alteration and increased enzymatic activity in genetically modified photoactivated adenylate cyclase OaPAC

por Raics, Katalin, Pirisi, Katalin, Zhuang, Bo, Fekete, Zsuzsanna, Kis-Bicskei, Nikolett, Pecsi, Ildiko, Ujfalusi, Kinga Pozsonyi, Telek, Elek, Li, Yin, Collado, Jinnette Tolentino, Tonge, Peter J., Meech, Stephen R., Vos, Marten H., Bodis, Emoke, Lukacs, Andras
Publicado 2023

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii

por Brust, Richard, Haigney, Allison, Lukacs, Andras, Gil, Agnieszka, Hossain, Shahrier, Addison, Kiri, Lai, Cheng-Tsung, Towrie, Michael, Greetham, Gregory M., Clark, Ian P., Illarionov, Boris, Bacher, Adelbert, Kim, Ryu-Ryun, Fischer, Markus, Simmerling, Carlos, Meech, Stephen R., Tonge, Peter J.
Publicado 2013

Positron Emission Tomography Imaging with 2-[(18)F]F-p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

por Zhang, Zhuo, Ordonez, Alvaro A., Wang, Hui, Li, Yong, Gogarty, Kayla R., Weinstein, Edward A., Daryaee, Fereidoon, Merino, Jonathan, Yoon, Grace E., Kalinda, Alvin S., Mease, Ronnie C., Iuliano, James N., Smith-Jones, Peter M., Jain, Sanjay K., Tonge, Peter J.
Publicado 2018

Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

por Karadi, Kristof, Kapetanaki, Sofia M., Raics, Katalin, Pecsi, Ildiko, Kapronczai, Robert, Fekete, Zsuzsanna, Iuliano, James N., Collado, Jinnette Tolentino, Gil, Agnieszka A., Orban, Jozsef, Nyitrai, Miklos, Greetham, Greg M., Vos, Marten H., Tonge, Peter J., Meech, Stephen R., Lukacs, Andras
Publicado 2020

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

por Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, MRK
Publicado 2018