Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance

por Tooke, Catherine L., Hinchliffe, Philip, Bonomo, Robert A., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Publicado 2020

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

por Tooke, Catherine L., Hinchliffe, Philip, Lang, Pauline A., Mulholland, Adrian J., Brem, Jürgen, Schofield, Christopher J., Spencer, James
Publicado 2019

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation

por Lohans, Christopher T., van Groesen, Emma, Kumar, Kiran, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Publicado 2018

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

por Tooke, Catherine L., Hinchliffe, Philip, Bragginton, Eilis C., Colenso, Charlotte K., Hirvonen, Viivi H.A., Takebayashi, Yuiko, Spencer, James
Publicado 2019

Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase

por Tooke, Catherine L., Hinchliffe, Philip, Beer, Michael, Zinovjev, Kirill, Colenso, Charlotte K., Schofield, Christopher J., Mulholland, Adrian J., Spencer, James
Publicado 2023

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

por Lohans, Christopher T., Freeman, Emily I., Groesen, Emma van, Tooke, Catherine L., Hinchliffe, Philip, Spencer, James, Brem, Jürgen, Schofield, Christopher J.
Publicado 2019

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

por Lucic, Anka, Malla, Tika R., Calvopiña, Karina, Tooke, Catherine L., Brem, Jürgen, McDonough, Michael A., Spencer, James, Schofield, Christopher J.
Publicado 2022

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

por Evans, Lindsay E., Krishna, Aishwarya, Ma, Yajing, Webb, Thomas E., Marshall, Dominic C., Tooke, Catherine L., Spencer, James, Clarke, Thomas B., Armstrong, Alan, Edwards, Andrew M.
Publicado 2019

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition...

por Hinchliffe, Philip, Tooke, Catherine L., Bethel, Christopher R., Wang, Benlian, Arthur, Christopher, Heesom, Kate J., Shapiro, Stuart, Schlatzer, Daniela M., Papp-Wallace, Krisztina M., Bonomo, Robert A., Spencer, James
Publicado 2022

Profiling interactions of vaborbactam with metallo-β-lactamases

por Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen
Publicado 2019

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

por Galdadas, Ioannis, Qu, Shen, Oliveira, Ana Sofia F, Olehnovics, Edgar, Mack, Andrew R, Mojica, Maria F, Agarwal, Pratul K, Tooke, Catherine L, Gervasio, Francesco Luigi, Spencer, James, Bonomo, Robert A, Mulholland, Adrian J, Haider, Shozeb
Publicado 2021

Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants

por Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Publicado 2019

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

por Hinchliffe, Philip, Yang, Qiu E., Portal, Edward, Young, Tom, Li, Hui, Tooke, Catherine L., Carvalho, Maria J., Paterson, Neil G., Brem, Jürgen, Niumsup, Pannika R., Tansawai, Uttapoln, Lei, Lei, Li, Mei, Shen, Zhangqi, Wang, Yang, Schofield, Christopher J., Mulholland, Adrian J, Shen, Jianzhong, Fey, Natalie, Walsh, Timothy R., Spencer, James
Publicado 2017

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

por Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.
Publicado 2021