Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer’s disease

por Toomey, Christina E., Heywood, Wendy, Benson, Bridget C., Packham, Georgia, Mills, Kevin, Lashley, Tammaryn
Publicado 2020

Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration

por Woollacott, Ione O. C., Toomey, Christina E., Strand, Catherine, Courtney, Robert, Benson, Bridget C., Rohrer, Jonathan D., Lashley, Tammaryn
Publicado 2020

Molecular forms of neurogranin in cerebrospinal fluid

por Nazir, Faisal Hayat, Camporesi, Elena, Brinkmalm, Gunnar, Lashley, Tammaryn, Toomey, Christina E., Kvartsberg, Hlin, Zetterberg, Henrik, Blennow, Kaj, Becker, Bruno
Publicado 2020

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes

por Fodder, Katherine, Murthy, Megha, Rizzu, Patrizia, Toomey, Christina E., Hasan, Rahat, Humphrey, Jack, Raj, Towfique, Lunnon, Katie, Mill, Jonathan, Heutink, Peter, Lashley, Tammaryn, Bettencourt, Conceição
Publicado 2023

Chemical traits of cerebral amyloid angiopathy in familial British‐, Danish‐, and non‐Alzheimerʼs dementias

por Michno, Wojciech, Koutarapu, Srinivas, Camacho, Rafael, Toomey, Christina, Stringer, Katie, Minta, Karolina, Ge, Junyue, Jha, Durga, Fernandez‐Rodriguez, Julia, Brinkmalm, Gunnar, Zetterberg, Henrik, Blennow, Kaj, Ryan, Natalie S., Lashley, Tammaryn, Hanrieder, Jörg
Publicado 2022

Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

por Setó‐Salvia, Núria, Esteras, Noemi, de Silva, Rohan, de Pablo‐Fernandez, Eduardo, Arber, Charles, Toomey, Christina E., Polke, James M., Morris, Huw R., Rohrer, Jonathan D., Abramov, Andrey Y., Patani, Rickie, Wray, Selina, Warner, Thomas T.
Publicado 2021

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

por Rueda‐Carrasco, Javier, Sokolova, Dimitra, Lee, Sang‐Eun, Childs, Thomas, Jurčáková, Natália, Crowley, Gerard, De Schepper, Sebastiaan, Ge, Judy Z, Lachica, Joanne I, Toomey, Christina E, Freeman, Oliver J, Hardy, John, Barnes, Samuel J, Lashley, Tammaryn, Stevens, Beth, Chang, Sunghoe, Hong, Soyon
Publicado 2023

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

por De Schepper, Sebastiaan, Ge, Judy Z., Crowley, Gerard, Ferreira, Laís S. S., Garceau, Dylan, Toomey, Christina E., Sokolova, Dimitra, Rueda-Carrasco, Javier, Shin, Sun-Hye, Kim, Jung-Seok, Childs, Thomas, Lashley, Tammaryn, Burden, Jemima J., Sasner, Michael, Sala Frigerio, Carlo, Jung, Steffen, Hong, Soyon
Publicado 2023

P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease

por Lantero‐Rodriguez, Juan, Snellman, Anniina, Benedet, Andrea L, Milà‐Alomà, Marta, Camporesi, Elena, Montoliu‐Gaya, Laia, Ashton, Nicholas J, Vrillon, Agathe, Karikari, Thomas K, Gispert, Juan Domingo, Salvadó, Gemma, Shekari, Mahnaz, Toomey, Christina E, Lashley, Tammaryn L, Zetterberg, Henrik, Suárez‐Calvet, Marc, Brinkmalm, Gunnar, Rosa Neto, Pedro, Blennow, Kaj
Publicado 2021

Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s

por Toomey, Christina E., Heywood, Wendy E., Evans, James R., Lachica, Joanne, Pressey, Sarah N., Foti, Sandrine C., Al Shahrani, Mesfer, D’Sa, Karishma, Hargreaves, Iain P., Heales, Simon, Orford, Michael, Troakes, Claire, Attems, Johannes, Gelpi, Ellen, Palkovits, Miklos, Lashley, Tammaryn, Gentleman, Steve M., Revesz, Tamas, Mills, Kevin, Gandhi, Sonia
Publicado 2022