Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension

por Heuberger, Benjamin D., Pal, Ayan, Del Frate, Francesca, Topkar, Ved V., Szostak, Jack W.
Publicado 2015

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets

por Tsai, Shengdar Q., Nguyen, Nhu T., Malagon-Lopez, Jose, Topkar, Ved V., Aryee, Martin J., Joung, J. Keith
Publicado 2017

GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

por Tsai, Shengdar Q., Zheng, Zongli, Nguyen, Nhu T., Liebers, Matthew, Topkar, Ved V., Thapar, Vishal, Wyvekens, Nicolas, Khayter, Cyd, Iafrate, A. John, Le, Long P., Aryee, Martin J., Joung, J. Keith
Publicado 2014

Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures

por Kappel, Kalli, Zhang, Kaiming, Su, Zhaoming, Watkins, Andrew M., Kladwang, Wipapat, Li, Shanshan, Pintilie, Grigore, Topkar, Ved V., Rangan, Ramya, Zheludev, Ivan N., Yesselman, Joseph D., Chiu, Wah, Das, Rhiju
Publicado 2020

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

por Leppek, Kathrin, Byeon, Gun Woo, Kladwang, Wipapat, Wayment-Steele, Hannah K., Kerr, Craig H., Xu, Adele F., Kim, Do Soon, Topkar, Ved V., Choe, Christian, Rothschild, Daphna, Tiu, Gerald C., Wellington-Oguri, Roger, Fujii, Kotaro, Sharma, Eesha, Watkins, Andrew M., Nicol, John J., Romano, Jonathan, Tunguz, Bojan, Participants, Eterna, Barna, Maria, Das, Rhiju
Publicado 2021

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

por Leppek, Kathrin, Byeon, Gun Woo, Kladwang, Wipapat, Wayment-Steele, Hannah K., Kerr, Craig H., Xu, Adele F., Kim, Do Soon, Topkar, Ved V., Choe, Christian, Rothschild, Daphna, Tiu, Gerald C., Wellington-Oguri, Roger, Fujii, Kotaro, Sharma, Eesha, Watkins, Andrew M., Nicol, John J., Romano, Jonathan, Tunguz, Bojan, Diaz, Fernando, Cai, Hui, Guo, Pengbo, Wu, Jiewei, Meng, Fanyu, Shi, Shuai, Participants, Eterna, Dormitzer, Philip R., Solórzano, Alicia, Barna, Maria, Das, Rhiju
Publicado 2022