Conserved Peptide Fragmentation as a Benchmarking Tool for Mass Spectrometers and a Discriminating Feature for Targeted Proteomics

por Toprak, Umut H., Gillet, Ludovic C., Maiolica, Alessio, Navarro, Pedro, Leitner, Alexander, Aebersold, Ruedi
Publicado 2014

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

por Shostak, Anton, Ruppert, Bianca, Ha, Nati, Bruns, Philipp, Toprak, Umut H., Eils, Roland, Schlesner, Matthias, Diernfellner, Axel, Brunner, Michael
Publicado 2016

Accurate and efficient detection of gene fusions from RNA sequencing data

por Uhrig, Sebastian, Ellermann, Julia, Walther, Tatjana, Burkhardt, Pauline, Fröhlich, Martina, Hutter, Barbara, Toprak, Umut H., Neumann, Olaf, Stenzinger, Albrecht, Scholl, Claudia, Fröhling, Stefan, Brors, Benedikt
Publicado 2021

FOXR2 Stabilizes MYCN Protein and Identifies Non–MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome

por Schmitt-Hoffner, Felix, van Rijn, Sjoerd, Toprak, Umut H., Mauermann, Monika, Rosemann, Felix, Heit-Mondrzyk, Anke, Hübner, Jens-Martin, Camgöz, Aylin, Hartlieb, Sabine, Pfister, Stefan M., Henrich, Kai-Oliver, Westermann, Frank, Kool, Marcel
Publicado 2021

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

por Jabs, Julia, Zickgraf, Franziska M, Park, Jeongbin, Wagner, Steve, Jiang, Xiaoqi, Jechow, Katharina, Kleinheinz, Kortine, Toprak, Umut H, Schneider, Marc A, Meister, Michael, Spaich, Saskia, Sütterlin, Marc, Schlesner, Matthias, Trumpp, Andreas, Sprick, Martin, Eils, Roland, Conrad, Christian
Publicado 2017

Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma

por Afanasyeva, Elena A, Gartlgruber, Moritz, Ryl, Tatsiana, Decaesteker, Bieke, Denecker, Geertrui, Mönke, Gregor, Toprak, Umut H, Florez, Andres, Torkov, Alica, Dreidax, Daniel, Herrmann, Carl, Okonechnikov, Konstantin, Ek, Sara, Sharma, Ashwini Kumar, Sagulenko, Vitaliya, Speleman, Frank, Henrich, Kai-Oliver, Westermann, Frank
Publicado 2021

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities

por Giesen, Nicola, Paramasivam, Nagarajan, Toprak, Umut H., Huebschmann, Daniel, Xu, Jing, Uhrig, Sebastian, Samur, Mehmet, Bähr, Stella, Fröhlich, Martina, Mughal, Sadaf S., Mai, Elias K., Jauch, Anna, Müller-Tidow, Carsten, Brors, Benedikt, Munshi, Nikhil, Goldschmidt, Hartmut, Weinhold, Niels, Schlesner, Matthias, Raab, Marc S.
Publicado 2022

Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

por Weichenhan, Dieter, Riedel, Anna, Meinen, Charlotte, Basic, Alisa, Toth, Reka, Bähr, Marion, Lutsik, Pavlo, Hey, Joschka, Sollier, Etienne, Toprak, Umut H., Kelekçi, Simge, Lin, Yu-Yu, Hakobyan, Mariam, Touzart, Aurore, Goyal, Ashish, Wierzbinska, Justyna A., Schlesner, Matthias, Westermann, Frank, Lipka, Daniel B., Plass, Christoph
Publicado 2023

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

por George, Sally L, Lorenzi, Federica, King, David, Hartlieb, Sabine, Campbell, James, Pemberton, Helen, Toprak, Umut H, Barker, Karen, Tall, Jennifer, da Costa, Barbara Martins, van den Boogaard, Marlinde L, Dolman, M Emmy M, Molenaar, Jan J, Bryant, Helen E, Westermann, Frank, Lord, Christopher J, Chesler, Louis
Publicado 2020

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

por Ishaque, Naveed, Abba, Mohammed L., Hauser, Christine, Patil, Nitin, Paramasivam, Nagarajan, Huebschmann, Daniel, Leupold, Jörg Hendrik, Balasubramanian, Gnana Prakash, Kleinheinz, Kortine, Toprak, Umut H., Hutter, Barbara, Benner, Axel, Shavinskaya, Anna, Zhou, Chan, Gu, Zuguang, Kerssemakers, Jules, Marx, Alexander, Moniuszko, Marcin, Kozlowski, Miroslaw, Reszec, Joanna, Niklinski, Jacek, Eils, Jürgen, Schlesner, Matthias, Eils, Roland, Brors, Benedikt, Allgayer, Heike
Publicado 2018

S120: MNX1-ACTIVATING ENHANCER HIJACKING EVENTS IN ACUTE MYELOID LEUKEMIA WITH DELETIONS ON CHROMOSOME 7Q

por Riedel, Anna, Wierzbińska, Justyna A., Toprak, Umut H., Touzart, Aurore, Sollier, Etienne, Kelekçi, Simge, Kelly, Katherine, Weichenhan, Dieter, Pejkovska, Anastasija, Goyal, Ashish, Meinen, Charlotte, Schlesner, Matthias, Westermann, Frank, Brors, Benedikt, Bullinger, Lars, Greif, Philipp, Lübbert, Michael, Heidel, Florian, Fischer, Thomas, Gebhard, Claudia, Schlegelberger, Brigitte, Göhring, Gudrun, Behrens, Yvonne, Jahn, Ekaterina, Döhner, Hartmut, Döhner, Konstanze, Delwel, Ruud, Lutsik, Pavlo, Lipka, Daniel B., Plass, Christoph
Publicado 2023

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

por Hartlieb, Sabine A., Sieverling, Lina, Nadler-Holly, Michal, Ziehm, Matthias, Toprak, Umut H., Herrmann, Carl, Ishaque, Naveed, Okonechnikov, Konstantin, Gartlgruber, Moritz, Park, Young-Gyu, Wecht, Elisa Maria, Savelyeva, Larissa, Henrich, Kai-Oliver, Rosswog, Carolina, Fischer, Matthias, Hero, Barbara, Jones, David T. W., Pfaff, Elke, Witt, Olaf, Pfister, Stefan M., Volckmann, Richard, Koster, Jan, Kiesel, Katharina, Rippe, Karsten, Taschner-Mandl, Sabine, Ambros, Peter, Brors, Benedikt, Selbach, Matthias, Feuerbach, Lars, Westermann, Frank
Publicado 2021

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone

por Lutsik, Pavlo, Baude, Annika, Mancarella, Daniela, Öz, Simin, Kühn, Alexander, Toth, Reka, Hey, Joschka, Toprak, Umut H., Lim, Jinyeong, Nguyen, Viet Ha, Jiang, Chao, Mayakonda, Anand, Hartmann, Mark, Rosemann, Felix, Breuer, Kersten, Vonficht, Dominik, Grünschläger, Florian, Lee, Suman, Schuhmacher, Maren Kirstin, Kusevic, Denis, Jauch, Anna, Weichenhan, Dieter, Zustin, Jozef, Schlesner, Matthias, Haas, Simon, Park, Joo Hyun, Park, Yoon Jung, Oppermann, Udo, Jeltsch, Albert, Haller, Florian, Fellenberg, Jörg, Lindroth, Anders M., Plass, Christoph
Publicado 2020

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas

por López, Cristina, Schleussner, Nikolai, Bernhart, Stephan H., Kleinheinz, Kortine, Sungalee, Stephanie, Sczakiel, Henrike L., Kretzmer, Helene, Toprak, Umut H., Glaser, Selina, Wagener, Rabea, Ammerpohl, Ole, Bens, Susanne, Giefing, Maciej, González Sánchez, Juan C., Apic, Gordana, Hübschmann, Daniel, Janz, Martin, Kreuz, Markus, Mottok, Anja, Müller, Judith M., Seufert, Julian, Hoffmann, Steve, Korbel, Jan O., Russell, Robert B., Schüle, Roland, Trümper, Lorenz, Klapper, Wolfram, Radlwimmer, Bernhard, Lichter, Peter, Küppers, Ralf, Schlesner, Matthias, Mathas, Stephan, Siebert, Reiner
Publicado 2022

The genomic and transcriptional landscape of primary central nervous system lymphoma

por Radke, Josefine, Ishaque, Naveed, Koll, Randi, Gu, Zuguang, Schumann, Elisa, Sieverling, Lina, Uhrig, Sebastian, Hübschmann, Daniel, Toprak, Umut H., López, Cristina, Hostench, Xavier Pastor, Borgoni, Simone, Juraeva, Dilafruz, Pritsch, Fabienne, Paramasivam, Nagarajan, Balasubramanian, Gnana Prakash, Schlesner, Matthias, Sahay, Shashwat, Weniger, Marc, Pehl, Debora, Radbruch, Helena, Osterloh, Anja, Korfel, Agnieszka, Misch, Martin, Onken, Julia, Faust, Katharina, Vajkoczy, Peter, Moskopp, Dag, Wang, Yawen, Jödicke, Andreas, Trümper, Lorenz, Anagnostopoulos, Ioannis, Lenze, Dido, Küppers, Ralf, Hummel, Michael, Schmitt, Clemens A., Wiestler, Otmar D., Wolf, Stephan, Unterberg, Andreas, Eils, Roland, Herold-Mende, Christel, Brors, Benedikt, Siebert, Reiner, Wiemann, Stefan, Heppner, Frank L.
Publicado 2022

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

por López, Cristina, Kleinheinz, Kortine, Aukema, Sietse M., Rohde, Marius, Bernhart, Stephan H., Hübschmann, Daniel, Wagener, Rabea, Toprak, Umut H., Raimondi, Francesco, Kreuz, Markus, Waszak, Sebastian M., Huang, Zhiqin, Sieverling, Lina, Paramasivam, Nagarajan, Seufert, Julian, Sungalee, Stephanie, Russell, Robert B., Bausinger, Julia, Kretzmer, Helene, Ammerpohl, Ole, Bergmann, Anke K., Binder, Hans, Borkhardt, Arndt, Brors, Benedikt, Claviez, Alexander, Doose, Gero, Feuerbach, Lars, Haake, Andrea, Hansmann, Martin-Leo, Hoell, Jessica, Hummel, Michael, Korbel, Jan O., Lawerenz, Chris, Lenze, Dido, Radlwimmer, Bernhard, Richter, Julia, Rosenstiel, Philip, Rosenwald, Andreas, Schilhabel, Markus B., Stein, Harald, Stilgenbauer, Stephan, Stadler, Peter F., Szczepanowski, Monika, Weniger, Marc A., Zapatka, Marc, Eils, Roland, Lichter, Peter, Loeffler, Markus, Möller, Peter, Trümper, Lorenz, Klapper, Wolfram, Hoffmann, Steve, Küppers, Ralf, Burkhardt, Birgit, Schlesner, Matthias, Siebert, Reiner
Publicado 2019

Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

por Hübschmann, Daniel, Kleinheinz, Kortine, Wagener, Rabea, Bernhart, Stephan H., López, Cristina, Toprak, Umut H., Sungalee, Stephanie, Ishaque, Naveed, Kretzmer, Helene, Kreuz, Markus, Waszak, Sebastian M., Paramasivam, Nagarajan, Ammerpohl, Ole, Aukema, Sietse M., Beekman, Renée, Bergmann, Anke K., Bieg, Matthias, Binder, Hans, Borkhardt, Arndt, Borst, Christoph, Brors, Benedikt, Bruns, Philipp, Carrillo de Santa Pau, Enrique, Claviez, Alexander, Doose, Gero, Haake, Andrea, Karsch, Dennis, Haas, Siegfried, Hansmann, Martin-Leo, Hoell, Jessica I., Hovestadt, Volker, Huang, Bingding, Hummel, Michael, Jäger-Schmidt, Christina, Kerssemakers, Jules N. A., Korbel, Jan O., Kube, Dieter, Lawerenz, Chris, Lenze, Dido, Martens, Joost H. A., Ott, German, Radlwimmer, Bernhard, Reisinger, Eva, Richter, Julia, Rico, Daniel, Rosenstiel, Philip, Rosenwald, Andreas, Schillhabel, Markus, Stilgenbauer, Stephan, Stadler, Peter F., Martín-Subero, José I., Szczepanowski, Monika, Warsow, Gregor, Weniger, Marc A., Zapatka, Marc, Valencia, Alfonso, Stunnenberg, Hendrik G., Lichter, Peter, Möller, Peter, Loeffler, Markus, Eils, Roland, Klapper, Wolfram, Hoffmann, Steve, Trümper, Lorenz, Küppers, Ralf, Schlesner, Matthias, Siebert, Reiner
Publicado 2021