Initial statin dose after myocardial infarction and long-term cardiovascular outcomes

por Kytö, Ville, Rautava, Päivi, Tornio, Aleksi
Publicado 2022

Digoxin use and outcomes after myocardial infarction in patients with atrial fibrillation

por Kytö, Ville, Saraste, Antti, Rautava, Päivi, Tornio, Aleksi
Publicado 2022

Clinical Studies on Drug–Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation

por Tornio, Aleksi, Filppula, Anne M., Niemi, Mikko, Backman, Janne T.
Publicado 2019

Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans

por Neuvonen, Mikko, Tornio, Aleksi, Hirvensalo, Päivi, Backman, Janne T., Niemi, Mikko
Publicado 2021

Lack of Statin Therapy and Outcomes After Ischemic Stroke: A Population-Based Study

por Åivo, Julia, Ruuskanen, Jori O., Tornio, Aleksi, Rautava, Päivi, Kytö, Ville
Publicado 2023

Placental transporter‐mediated drug interactions and offspring congenital anomalies

por Ellfolk, Maria, Tornio, Aleksi, Niemi, Mikko, Leinonen, Maarit K., Lahesmaa‐Korpinen, Anna‐Maria, Malm, Heli
Publicado 2020

Pharmacogenomics of celiprolol – evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics

por Hirvensalo, Päivi, Tornio, Aleksi, Tapaninen, Tuija, Paile‐Hyvärinen, Maria, Neuvonen, Mikko, Backman, Janne T., Niemi, Mikko
Publicado 2021

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans

por Itkonen, Matti K., Tornio, Aleksi, Filppula, Anne M., Neuvonen, Mikko, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Publicado 2017

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel

por Itkonen, Matti K., Tornio, Aleksi, Lapatto‐Reiniluoto, Outi, Neuvonen, Mikko, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Publicado 2018

Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

por Tapaninen, Tuija, Olkkola, Aleksi M., Tornio, Aleksi, Neuvonen, Mikko, Elonen, Erkki, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Publicado 2019

Investigating Real‐World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records

por Tornio, Aleksi, Flynn, Rob, Morant, Steve, Velten, Elena, Palmer, Colin N. A., MacDonald, Thomas M., Doney, Alex S. F.
Publicado 2017

Enantiospecific Pharmacogenomics of Fluvastatin

por Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Kiander, Wilma, Kidron, Heidi, Paile‐Hyvärinen, Maria, Tapaninen, Tuija, Backman, Janne T., Niemi, Mikko
Publicado 2019

Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants

por Lönnberg, K. Ivar, Tornio, Aleksi, Hirvensalo, Päivi, Keskitalo, Jenni, Mustaniemi, Anna-Liina, Kiiski, Johanna I., Filppula, Anne M., Niemi, Mikko
Publicado 2023

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

por Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Tapaninen, Tuija, Paile‐Hyvärinen, Maria, Kärjä, Vesa, Männistö, Ville T., Pihlajamäki, Jussi, Backman, Janne T., Niemi, Mikko
Publicado 2017

Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

por Lehtisalo, Minna, Keskitalo, Jenni E., Tornio, Aleksi, Lapatto‐Reiniluoto, Outi, Deng, Feng, Jaatinen, Taina, Viinamäki, Jenni, Neuvonen, Mikko, Backman, Janne T., Niemi, Mikko
Publicado 2020

Genomewide Association Study of Simvastatin Pharmacokinetics

por Mykkänen, Anssi J. H., Taskinen, Suvi, Neuvonen, Mikko, Paile‐Hyvärinen, Maria, Tarkiainen, E. Katriina, Lilius, Tuomas, Tapaninen, Tuija, Backman, Janne T., Tornio, Aleksi, Niemi, Mikko
Publicado 2022

A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics

por Lehtisalo, Minna, Taskinen, Suvi, Tarkiainen, E. Katriina, Neuvonen, Mikko, Viinamäki, Jenni, Paile‐Hyvärinen, Maria, Lilius, Tuomas O., Tapaninen, Tuija, Backman, Janne T., Tornio, Aleksi, Niemi, Mikko
Publicado 2022

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records

por Melhem, Alaa’ Lutfi, Chourasia, Mehul Kumar, Bigossi, Margherita, Maroteau, Cyrielle, Taylor, Alasdair, Pola, Roberto, Dawed, Adem Y., Tornio, Aleksi, Palmer, Colin N. A., Siddiqui, Moneeza K.
Publicado 2021

Identification of Glycochenodeoxycholate 3‐O‐Glucuronide and Glycodeoxycholate 3‐O‐Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers

por Neuvonen, Mikko, Hirvensalo, Päivi, Tornio, Aleksi, Rago, Brian, West, Mark, Lazzaro, Sarah, Mathialagan, Sumathy, Varma, Manthena, Cerny, Matthew A., Costales, Chester, Ramanathan, Ragu, Rodrigues, A. David, Niemi, Mikko
Publicado 2020

The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial

por Tornio, Aleksi, Bigossi, Margherita, Siddiqui, Moneeza K., Kennedy, Gwen, Melhem, Ala’a, Chourasia, Mehul K., Maroteau, Cyrielle, Pola, Roberto, Chasman, Daniel I., Doney, Alexander S. F., Palmer, Colin N. A.
Publicado 2023