mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci

por Kelsey, Ilana, Zbinden, Marie, Byles, Vanessa, Torrence, Margaret, Manning, Brendan D.
Publicado 2017

IMPROVED HEALTHSPAN AND LIFESPAN WITH LATE ONSET PHARMACOLOGICAL OR DIETARY INTERVENTIONS IN MICE

por Mitchell, Sarah, MacArthur, Michael, Kane, Alice, Torrence, Margaret, Manning, Brendan, mItchell, James
Publicado 2019

Late-Onset Pharmacological or Dietary Interventions Improve Healthspan and Lifespan in Male and Female Mice

por Mitchell, Sarah, MacArthur, Michael, Kane, Alice, Torrence, Margaret, Mehmet, Huseyin, Vath, James, Manning, Brendan, Mitchell, James
Publicado 2020

Longevity-Extending MetAP2 Inhibitors Induce Caloric Restriction Through P53-Dependent Induction of GDF-15

por MacArthur, Michael, Mitchell, Sarah, Jung, Jon, Torrence, Margaret, Kane, Alice, Mehmet, Huseyin, Manning, Brendan, Mitchell, James
Publicado 2020

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

por Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Publicado 2021

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

por Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.
Publicado 2022

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

por McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Publicado 2022

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

por Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie
Publicado 2017

Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

por Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
Publicado 2014