The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

por Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Publicado 2021

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

por Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.
Publicado 2022

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

por McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Publicado 2022

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

por Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie
Publicado 2017

Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

por Mayers, Jared R., Wu, Chen, Clish, Clary B., Kraft, Peter, Torrence, Margaret E., Fiske, Brian P., Yuan, Chen, Bao, Ying, Townsend, Mary K., Tworoger, Shelley S., Davidson, Shawn M., Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L., Ogino, Shuji, Stampfer, Meir J., Giovannucci, Edward L., Qian, Zhi Rong, Rubinson, Douglas A., Ma, Jing, Sesso, Howard D., Gaziano, John Michael, Cochrane, Barbara B., Liu, Simin, Wactawski–Wende, Jean, Manson, JoAnn E., Pollak, Michael N., Kimmelman, Alec C., Souza, Amanda, Pierce, Kerry, Wang, Thomas J., Gerszten, Robert E., Fuchs, Charles S., Heiden, Matthew G. Vander, Wolpin, Brian M.
Publicado 2014