Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

por Roberts, Adam J., Torrie, Leah S., Wyllie, Susan, Fairlamb, Alan H.
Publicado 2014

Burkholderia pseudomallei d‐alanine‐d‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

por Díaz‐Sáez, Laura, Torrie, Leah S., McElroy, Stuart P., Gray, David, Hunter, William N.
Publicado 2019

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

por Tidten-Luksch, Naomi, Grimaldi, Raffaella, Torrie, Leah S., Frearson, Julie A., Hunter, William N., Brenk, Ruth
Publicado 2012

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

por Torrie, Leah S., Zuccotto, Fabio, Robinson, David A., Gray, David W., Gilbert, Ian H., De Rycker, Manu
Publicado 2019

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

por Zmuda, Filip, Shepherd, Sharon M., Ferguson, Michael A. J., Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado 2019

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

por McElroy, Stuart P., Nomura, Toshifumi, Torrie, Leah S., Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W. H. Irwin
Publicado 2013

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

por Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Publicado 2012

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

por Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M., Jones, Deuan, Scott, Alison, Craggs, Peter D., Cortes, Alvaro, Gray, David W., Torrie, Leah S., De Rycker, Manu
Publicado 2019

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

por Torrie, Leah S., Wyllie, Susan, Spinks, Daniel, Oza, Sandra L., Thompson, Stephen, Harrison, Justin R., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H., Frearson, Julie A.
Publicado 2009

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

por Cleghorn, Laura A T, Woodland, Andrew, Collie, Iain T, Torrie, Leah S, Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G, Mottram, Jeremy C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado 2011

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

por Fang, Wenxia, Robinson, David A., Raimi, Olawale G., Blair, David E., Harrison, Justin R., Lockhart, Deborah E. A., Torrie, Leah S., Ruda, Gian Filippo, Wyatt, Paul G., Gilbert, Ian H., van Aalten, Daan M. F.
Publicado 2015

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

por Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P., Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Gilbert, Ian H., Wyatt, Paul G.
Publicado 2017

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

por Lima, Marta L., Tulloch, Lindsay B., Corpas-Lopez, Victoriano, Carvalho, Sandra, Wall, Richard J., Milne, Rachel, Rico, Eva, Patterson, Stephen, Gilbert, Ian H., Moniz, Sonia, MacLean, Lorna, Torrie, Leah S., Morgillo, Carmine, Horn, David, Zuccotto, Fabio, Wyllie, Susan
Publicado 2022

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

por Milne, Rachel, Wiedemar, Natalie, Corpas-Lopez, Victoriano, Moynihan, Eoin, Wall, Richard J., Dawson, Alice, Robinson, David A., Shepherd, Sharon M., Smith, Robert J., Hallyburton, Irene, Post, John M., Dowers, Karen, Torrie, Leah S., Gilbert, Ian H., Baragaña, Beatriz, Patterson, Stephen, Wyllie, Susan
Publicado 2022

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

por Torrie, Leah S., Robinson, David A., Thomas, Michael G., Hobrath, Judith V., Shepherd, Sharon M., Post, John M., Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J., Wrobel, Karolina, Edwards, Darren P., Gilbert, Ian H., Gray, David W., Fairlamb, Alan H., De Rycker, Manu
Publicado 2020

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

por Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A, Luksch, Torsten, Smith, Alasdair, Torrie, Leah S, McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T, Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Publicado 2015

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

por Harrison, Justin R., Brand, Stephen, Smith, Victoria, Robinson, David A., Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S., Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicado 2018

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

por Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Publicado 2017

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

por Corpas-Lopez, Victoriano, Moniz, Sonia, Thomas, Michael, Wall, Richard J., Torrie, Leah S., Zander-Dinse, Dorothea, Tinti, Michele, Brand, Stephen, Stojanovski, Laste, Manthri, Sujatha, Hallyburton, Irene, Zuccotto, Fabio, Wyatt, Paul G., De Rycker, Manu, Horn, David, Ferguson, Michael A. J., Clos, Joachim, Read, Kevin D., Fairlamb, Alan H., Gilbert, Ian H., Wyllie, Susan
Publicado 2018

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

por Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicado 2011