Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

por Paoletta, Silvia, Tosh, Dilip K., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado 2014

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

por Navratna, Vikas, Tosh, Dilip K., Jacobson, Kenneth A., Gouaux, Eric
Publicado 2018

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

por Jacobson, Kenneth A., Tosh, Dilip K., Jain, Shanu, Gao, Zhan-Guo
Publicado 2019

Structure activity relationship of novel antiviral nucleosides against Enterovirus A71

por Tosh, Dilip K., Toti, Kiran S., Hurst, Brett L., Julander, Justin G., Jacobson, Kenneth A.
Publicado 2020

Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A(3 )adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

por Wan, Tina C, Tosh, Dilip K, Du, Lili, Gizewski, Elizabeth T, Jacobson, Kenneth A, Auchampach, John A
Publicado 2011

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors()

por Jacobson, Kenneth A., Gao, Zhan-Guo, Paoletta, Silvia, Kiselev, Evgeny, Chakraborty, Saibal, Jayasekara, P. Suresh, Balasubramanian, Ramachandran, Tosh, Dilip K.
Publicado 2014

Adenosine A(3) Receptor (A(3)AR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice

por Sgambellone, Silvia, Marri, Silvia, Catarinicchia, Stefano, Pini, Alessandro, Tosh, Dilip K., Jacobson, Kenneth A., Masini, Emanuela, Salvemini, Daniela, Lucarini, Laura
Publicado 2022

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A(3) Adenosine Receptor Agonists

por Tosh, Dilip K., Finley, Amanda, Paoletta, Silvia, Moss, Steven M., Gao, Zhan-Guo, Gizewski, Elizabeth T., Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado 2014

Targeting the A(3) adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

por Singh, Anand Kumar, Mahalingam, Rajasekaran, Squillace, Silvia, Jacobson, Kenneth A., Tosh, Dilip K., Dharmaraj, Shruti, Farr, Susan A., Kavelaars, Annemieke, Salvemini, Daniela, Heijnen, Cobi J.
Publicado 2022

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A(3) Adenosine Receptor Agonists

por Tosh, Dilip K., Ciancetta, Antonella, Warnick, Eugene, O’Connor, Robert, Chen, Zhoumou, Gizewski, Elizabeth, Crane, Steven, Gao, Zhan-Guo, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Publicado 2016

Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice

por Whitehead, Gregory S., Karcz, Tadeusz P., Tosh, Dilip K., Jung, Young-Hwan, Wen, Zhiwei, Campbell, Ryan G., Gopinatth, Varun, Gao, Zhan-Guo, Jacobson, Kenneth A., Cook, Donald N.
Publicado 2022

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists

por Tosh, Dilip K., Ciancetta, Antonella, Mannes, Philip, Warnick, Eugene, Janowsky, Aaron, Eshleman, Amy J., Gizewski, Elizabeth, Brust, Tarsis F., Bohn, Laura M., Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado 2018