The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

por Dunmore, Benjamin J., Drake, Kylie M., Upton, Paul D., Toshner, Mark R., Aldred, Micheala A., Morrell, Nicholas W.
Publicado 2013

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood

por Ormiston, Mark L., Toshner, Mark R., Kiskin, Fedir N., Huang, Christopher J. Z., Groves, Emily, Morrell, Nicholas W., Rana, Amer A.
Publicado 2015

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension

por Toshner, Mark R., Gopalan, Deepa, Suntharalingam, Jay, Treacy, Carmen, Soon, Elaine, Sheares, Karen K., Morrell, Nicholas W., Screaton, Nicholas, Pepke-Zaba, Joanna
Publicado 2010

Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease?

por Sofianopoulou, Eleni, Church, Colin, Coghlan, Gerry, Howard, Luke, Johnson, Martin, Kiely, David G., Lawrie, Allan, Lordan, James, Wilkins, Martin R., Wort, Stephen J., Morrell, Nicholas W., Toshner, Mark R.
Publicado 2020

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice

por Crosby, Alexi, Toshner, Mark R., Southwood, Mark R., Soon, Elaine, Dunmore, Benjamin J., Groves, Emily, Moore, Stephen, Wright, Penny, Ottersbach, Katrin, Bennett, Cavan, Guerrero, Jose, Ghevaert, Cedric, Morrell, Nicholas W.
Publicado 2018

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension

por Rhodes, Christopher J., Ghataorhe, Pavandeep, Wharton, John, Rue-Albrecht, Kevin C., Hadinnapola, Charaka, Watson, Geoffrey, Bleda, Marta, Haimel, Matthias, Coghlan, Gerry, Corris, Paul A., Howard, Luke S., Kiely, David G., Peacock, Andrew J., Pepke-Zaba, Joanna, Toshner, Mark R., Wort, S. John, Gibbs, J. Simon R., Lawrie, Allan, Gräf, Stefan, Morrell, Nicholas W., Wilkins, Martin R.
Publicado 2017

EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results fro...

por Lewis, Robert A., Armstrong, Iain, Bergbaum, Carmel, Brewis, Melanie J., Cannon, John, Charalampopoulos, Athanasios, Church, A. Colin, Coghlan, J. Gerry, Davies, Rachel J., Dimopoulos, Konstantinos, Elliot, Charlie, Gibbs, J. Simon R., Gin-Sing, Wendy, Haji, Gulam, Hameed, Abdul G., Howard, Luke S., Johnson, Martin K., Kempny, Aleksander, Kiely, David G., Lo Giudice, Francesco, McCabe, Colm, Peacock, Andrew J., Peleyeju, Oyinkansola, Pepke-Zaba, Joanna, Polwarth, Gary, Price, Laura, Sabroe, Ian, Schreiber, Benjamin E., Sheares, Karen, Taboada, Dolores, Thompson, A.A. Roger, Toshner, Mark R., Wanjiku, Ivy, Wort, S. John, Yorke, Janelle, Condliffe, Robin
Publicado 2021

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

por Houchen-Wolloff, Linzy, Poinasamy, Krisnah, Holmes, Kate, Tarpey, Maryrose, Hastie, Claire, Raihani, Kelly, Rogers, Natalie, Smith, Nikki, Adams, Dawn, Burgess, Paul, Clark, Jean, Cranage, Clare, Desai, Mahadev, Geary, Nicola, Gill, Rhyan, Mangwani, Jitendra, Staunton, Lily, Berry, Colin, Bolton, Charlotte E, Chalder, Trudie, Chalmers, James, De Soyza, Anthony, Elneima, Omer, Geddes, John, Heller, Simon, Ho, Ling-Pei, Jacob, Joseph, McAuley, Hamish, Parmar, Aarti, Quint, Jennifer K, Raman, Betty, Rowland, Matthew, Singapuri, Amisha, Singh, Sally J, Thomas, David, Toshner, Mark R, Wain, Louise V, Horsley, Alex Robert, Marks, Michael, Brightling, Christopher E, Evans, Rachael A
Publicado 2022

Bayesian Inference Associates Rare KDR Variants With Specific Phenotypes in Pulmonary Arterial Hypertension

por Swietlik, Emilia M., Greene, Daniel, Zhu, Na, Megy, Karyn, Cogliano, Marcella, Rajaram, Smitha, Pandya, Divya, Tilly, Tobias, Lutz, Katie A., Welch, Carrie C.L., Pauciulo, Michael W., Southgate, Laura, Martin, Jennifer M., Treacy, Carmen M., Penkett, Christopher J., Stephens, Jonathan C., Bogaard, Harm J., Church, Colin, Coghlan, Gerry, Coleman, Anna W., Condliffe, Robin, Eichstaedt, Christina A., Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Girerd, Barbara, Grünig, Ekkehard, Holden, Simon, Howard, Luke, Humbert, Marc, Kiely, David G., Kovacs, Gabor, Lordan, Jim, Machado, Rajiv D., MacKenzie Ross, Robert V., McCabe, Colm, Moledina, Shahin, Montani, David, Olschewski, Horst, Pepke-Zaba, Joanna, Price, Laura, Rhodes, Christopher J., Seeger, Werner, Soubrier, Florent, Suntharalingam, Jay, Toshner, Mark R., Vonk Noordegraaf, Anton, Wharton, John, Wild, James M., Wort, Stephen John, Lawrie, Allan, Wilkins, Martin R., Trembath, Richard C., Shen, Yufeng, Chung, Wendy K., Swift, Andrew J., Nichols, William C., Morrell, Nicholas W., Gräf, Stefan
Publicado 2020

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

por Gräf, Stefan, Haimel, Matthias, Bleda, Marta, Hadinnapola, Charaka, Southgate, Laura, Li, Wei, Hodgson, Joshua, Liu, Bin, Salmon, Richard M., Southwood, Mark, Machado, Rajiv D., Martin, Jennifer M., Treacy, Carmen M., Yates, Katherine, Daugherty, Louise C., Shamardina, Olga, Whitehorn, Deborah, Holden, Simon, Aldred, Micheala, Bogaard, Harm J., Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A., Danesino, Cesare, Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J. Simon R., Girerd, Barbara, Houweling, Arjan C., Howard, Luke, Humbert, Marc, Kiely, David G., Kovacs, Gabor, MacKenzie Ross, Robert V., Moledina, Shahin, Montani, David, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Peacock, Andrew J., Pepke-Zaba, Joanna, Prokopenko, Inga, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Soubrier, Florent, Stein, Dan F., Suntharalingam, Jay, Swietlik, Emilia M., Toshner, Mark R., van Heel, David A., Vonk Noordegraaf, Anton, Waisfisz, Quinten, Wharton, John, Wort, Stephen J., Ouwehand, Willem H., Soranzo, Nicole, Lawrie, Allan, Upton, Paul D., Wilkins, Martin R., Trembath, Richard C., Morrell, Nicholas W.
Publicado 2018

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

por Rhodes, Christopher J, Batai, Ken, Bleda, Marta, Haimel, Matthias, Southgate, Laura, Germain, Marine, Pauciulo, Michael W, Hadinnapola, Charaka, Aman, Jurjan, Girerd, Barbara, Arora, Amit, Knight, Jo, Hanscombe, Ken B, Karnes, Jason H, Kaakinen, Marika, Gall, Henning, Ulrich, Anna, Harbaum, Lars, Cebola, Inês, Ferrer, Jorge, Lutz, Katie, Swietlik, Emilia M, Ahmad, Ferhaan, Amouyel, Philippe, Archer, Stephen L, Argula, Rahul, Austin, Eric D, Badesch, David, Bakshi, Sahil, Barnett, Christopher, Benza, Raymond, Bhatt, Nitin, Bogaard, Harm J, Burger, Charles D, Chakinala, Murali, Church, Colin, Coghlan, John G, Condliffe, Robin, Corris, Paul A, Danesino, Cesare, Debette, Stéphanie, Elliott, C Gregory, Elwing, Jean, Eyries, Melanie, Fortin, Terry, Franke, Andre, Frantz, Robert P, Frost, Adaani, Garcia, Joe G N, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J Simon R, Harley, John, He, Hua, Hill, Nicholas S, Hirsch, Russel, Houweling, Arjan C, Howard, Luke S, Ivy, Dunbar, Kiely, David G, Klinger, James, Kovacs, Gabor, Lahm, Tim, Laudes, Matthias, Machado, Rajiv D, MacKenzie Ross, Robert V, Marsolo, Keith, Martin, Lisa J, Moledina, Shahin, Montani, David, Nathan, Steven D, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Oudiz, Ronald J, Ouwehand, Willem H, Peacock, Andrew J, Pepke-Zaba, Joanna, Rehman, Zia, Robbins, Ivan, Roden, Dan M, Rosenzweig, Erika B, Saydain, Ghulam, Scelsi, Laura, Schilz, Robert, Seeger, Werner, Shaffer, Christian M, Simms, Robert W, Simon, Marc, Sitbon, Olivier, Suntharalingam, Jay, Tang, Haiyang, Tchourbanov, Alexander Y, Thenappan, Thenappan, Torres, Fernando, Toshner, Mark R, Treacy, Carmen M, Vonk Noordegraaf, Anton, Waisfisz, Quinten, Walsworth, Anna K, Walter, Robert E, Wharton, John, White, R James, Wilt, Jeffrey, Wort, Stephen J, Yung, Delphine, Lawrie, Allan, Humbert, Marc, Soubrier, Florent, Trégouët, David-Alexandre, Prokopenko, Inga, Kittles, Richard, Gräf, Stefan, Nichols, William C, Trembath, Richard C, Desai, Ankit A, Morrell, Nicholas W, Wilkins, Martin R
Publicado 2019