Lifespan of γ/δ T Cells

por Tough, David F., Sprent, Jonathan
Publicado 1998

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

por Tough, David F., Sun, Siquan, Sprent, Jonathan
Publicado 1997

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

por Sun, Siquan, Zhang, Xiaohong, Tough, David F., Sprent, Jonathan
Publicado 1998

Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives

por Ghiboub, Mohammed, Elfiky, Ahmed M. I., de Winther, Menno P. J., Harker, Nicola R., Tough, David F., de Jonge, Wouter J.
Publicado 2021

The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential

por Ghiboub, Mohammed, Bell, Matthew, Sinkeviciute, Dovile, Prinjha, Rab K., de Winther, Menno P. J., Harker, Nicola R., Tough, David F., de Jonge, Wouter J.
Publicado 2023

Rapid Turnover of Effector–Memory CD4(+) T Cells in Healthy Humans

por Macallan, Derek C., Wallace, Diana, Zhang, Yan, de Lara, Catherine, Worth, Andrew T., Ghattas, Hala, Griffin, George E., Beverley, Peter C.L., Tough, David F.
Publicado 2004

Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention

por Groves, Ian J., Jackson, Sarah E., Poole, Emma L., Nachshon, Aharon, Rozman, Batsheva, Schwartz, Michal, Prinjha, Rab K., Tough, David F., Sinclair, John H., Wills, Mark R.
Publicado 2021

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

por Davies, Matthew N., Bayry, Jagadeesh, Tchilian, Elma Z., Vani, Janakiraman, Shaila, Melkote S., Forbes, Emily K., Draper, Simon J., Beverley, Peter C. L., Tough, David F., Flower, Darren R.
Publicado 2009

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome

por Schulz, Danae, Mugnier, Monica R., Paulsen, Eda-Margaret, Kim, Hee-Sook, Chung, Chun-wa W., Tough, David F., Rioja, Inmaculada, Prinjha, Rab K., Papavasiliou, F. Nina, Debler, Erik W.
Publicado 2015

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

por Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher GC, Bronson, Paola G., Willé, David, Trynka, Gosia
Publicado 2019

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

por Kerscher, Bernhard, Barlow, Jillian L., Rana, Batika M., Jolin, Helen E., Gogoi, Mayuri, Bartholomew, Michelle A., Jhamb, Deepali, Pandey, Ashutosh, Tough, David F., van Oosterhout, Antoon J. M., McKenzie, Andrew N. J.
Publicado 2019

Preclinical models of arthritis for studying immunotherapy and immune tolerance

por Meehan, Gavin R, Thomas, Ranjeny, Al Khabouri, Shaima, Wehr, Pascale, Hilkens, Catharien MU, Wraith, David C, Sieghart, Daniela, Bonelli, Michael, Nagy, György, Garside, Paul, Tough, David F, Lewis, Huw D, Brewer, James M
Publicado 2021

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4(+) T cells to cytokines

por Cano-Gamez, Eddie, Soskic, Blagoje, Roumeliotis, Theodoros I., So, Ernest, Smyth, Deborah J., Baldrighi, Marta, Willé, David, Nakic, Nikolina, Esparza-Gordillo, Jorge, Larminie, Christopher G. C., Bronson, Paola G., Tough, David F., Rowan, Wendy C., Choudhary, Jyoti S., Trynka, Gosia
Publicado 2020

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression

por Grant, Francis M., Yang, Jie, Nasrallah, Rabab, Clarke, James, Sadiyah, Firas, Whiteside, Sarah K., Imianowski, Charlotte J., Kuo, Paula, Vardaka, Panagiota, Todorov, Tihomir, Zandhuis, Nordin, Patrascan, Ilinca, Tough, David F., Kometani, Kohei, Eil, Robert, Kurosaki, Tomohiro, Okkenhaug, Klaus, Roychoudhuri, Rahul
Publicado 2020

Immune disease risk variants regulate gene expression dynamics during CD4(+) T cell activation

por Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Matte, Julie C., Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Lorenc, Anna, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, David, Tough, David F., Bronson, Paola G., Trynka, Gosia
Publicado 2022

Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia

por Furze, Rebecca C., Molnar, Judit, Parr, Nigel J., Ahmad, Faiz, Henry, Yvette, Howe, David, Singh, Rajendra, Toal, Martin, Bassil, Anna K., Bernard, Sharon G., Davis, Robert P., Gibson, Adele, Maller, N. Claire, Sharp, Catriona, Tough, David F., Prinjha, Rab K., Lewis, Huw D.
Publicado 2022

HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

por Ghiboub, Mohammed, Zhao, Jing, Li Yim, Andrew Y. F., Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia H. P., Duarte, Jose M., Hakvoort, Theodorus B. M., Admiraal, Iris, Harker, Nicola R., Tough, David F., Henneman, Peter, de Winther, Menno P. J., de Jonge, Wouter J.
Publicado 2020

Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbe...

por Li Yim, Andrew Y. F., Ferrero, Enrico, Maratou, Klio, Lewis, Huw D., Royal, George, Tough, David F., Larminie, Chris, Mannens, Marcel M. A. M., Henneman, Peter, de Jonge, Wouter J., van de Sande, Marleen G. H., Gerlag, Danielle M., Prinjha, Rab K., Tak, Paul P.
Publicado 2021

Robust temporal map of human in vitro myelopoiesis using single-cell genomics

por Alsinet, Clara, Primo, Maria Nascimento, Lorenzi, Valentina, Bello, Erica, Kelava, Iva, Jones, Carla P., Vilarrasa-Blasi, Roser, Sancho-Serra, Carmen, Knights, Andrew J., Park, Jong-Eun, Wyspianska, Beata S., Trynka, Gosia, Tough, David F., Bassett, Andrew, Gaffney, Daniel J., Alvarez-Errico, Damiana, Vento-Tormo, Roser
Publicado 2022

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

por Ghiboub, Mohammed, Koster, Jan, Craggs, Peter D., Li Yim, Andrew Y. F., Shillings, Anthony, Hutchinson, Sue, Bingham, Ryan P., Gatfield, Kelly, Hageman, Ishtu L., Yao, Gang, O’Keefe, Heather P., Coffin, Aaron, Patel, Amish, Sloan, Lisa A., Mitchell, Darren J., Hayhow, Thomas G., Lunven, Laurent, Watson, Robert J., Blunt, Christopher E., Harrison, Lee A., Bruton, Gordon, Kumar, Umesh, Hamer, Natalie, Spaull, John R., Zwijnenburg, Danny A., Welting, Olaf, Hakvoort, Theodorus B. M., te Velde, Anje A., van Limbergen, Johan, Henneman, Peter, Prinjha, Rab K., de Winther, Menno P. J., Harker, Nicola R., Tough, David F., de Jonge, Wouter J.
Publicado 2022