Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

por Gaudelli, Nicole M., Townsend, Craig A.
Publicado 2014

A Practical Route to Substituted 7-Aminoindoles from Pyrrole-3-carboxaldehydes

por Outlaw, Victor K., Townsend, Craig A.
Publicado 2014

A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis

por Cohen, Douglas R., Townsend, Craig A.
Publicado 2017

Colorimetric Determination of Adenylation Domain Activity in Nonribosomal Peptide Synthetases by Using Chrome Azurol S

por Kahlert, Lukas, Lichstrahl, Michael S., Townsend, Craig A.
Publicado 2023

Monobactam formation in sulfazecin by a non-ribosomal peptide synthetase thioesterase

por Oliver, Ryan A., Li, Rongfeng, Townsend, Craig A.
Publicado 2017

Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK

por Lichstrahl, Michael S., Townsend, Craig A., Sinner, Erica K.
Publicado 2022

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

por Gaudelli, Nicole M., Long, Darcie H., Townsend, Craig A.
Publicado 2015

Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes

por Sinner, Erica K., Marous, Daniel R., Townsend, Craig A.
Publicado 2021

ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis

por Sinner, Erica K., Li, Rongfeng, Marous, Daniel R., Townsend, Craig A.
Publicado 2022

Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

por Newman, Adam G., Vagstad, Anna L., Storm, Philip A., Townsend, Craig A.
Publicado 2014

Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT

por Buller, Andrew R., Freeman, Michael F., Schildbach, Joel F., Townsend, Craig A.
Publicado 2014

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm

por Kumar, Gaurav, Galanis, Christos, Batchelder, Hunter R., Townsend, Craig A., Lamichhane, Gyanu
Publicado 2022

Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis

por Lichstrahl, Michael S., Kahlert, Lukas, Li, Rongfeng, Zandi, Trevor A., Yang, Jerry, Townsend, Craig. A.
Publicado 2023

Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

por Buller, Andrew R., Labonte, Jason W., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Publicado 2012

Ldt(Mav2), a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems

por Mattoo, Rohini, Lloyd, Evan P, Kaushik, Amit, Kumar, Pankaj, Brunelle, Julie L, Townsend, Craig A, Lamichhane, Gyanu
Publicado 2017

Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

por Saraiva, Raúl G., Huitt-Roehl, Callie R., Tripathi, Abhai, Cheng, Yi-Qiang, Bosch, Jürgen, Townsend, Craig A., Dimopoulos, George
Publicado 2018

Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

por Patel, Ketan D., d’Andrea, Felipe B., Gaudelli, Nicole M., Buller, Andrew R., Townsend, Craig A., Gulick, Andrew M.
Publicado 2019

T405, a New Penem, Exhibits In Vivo Efficacy against M. abscessus and Synergy with β-Lactams Imipenem and Cefditoren

por Rimal, Binayak, Batchelder, Hunter R., Story-Roller, Elizabeth, Panthi, Chandra M., Tabor, Chavis, Nuermberger, Eric L., Townsend, Craig A., Lamichhane, Gyanu
Publicado 2022

Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster

por Horsman, Mark E., Marous, Daniel R., Li, Rongfeng, Oliver, Ryan A., Byun, Byungjin, Emrich, Scott J., Boggess, Bill, Townsend, Craig A., Mobashery, Shahriar
Publicado 2017

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt(Mt2) by biapenem and tebipenem

por Bianchet, Mario A., Pan, Ying H., Basta, Leighanne A. Brammer, Saavedra, Harry, Lloyd, Evan P., Kumar, Pankaj, Mattoo, Rohini, Townsend, Craig A., Lamichhane, Gyanu
Publicado 2017