Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling

por Horn, Margaux A., Trafford, Andrew W.
Publicado 2016

Calcium and Excitation-Contraction Coupling in the Heart

por Eisner, David A., Caldwell, Jessica L., Kistamás, Kornél, Trafford, Andrew W.
Publicado 2017

A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reco...

por Colman, Michael A., Pinali, Christian, Trafford, Andrew W., Zhang, Henggui, Kitmitto, Ashraf
Publicado 2017

Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection?

por Hutchings, David Charles, Anderson, Simon George, Caldwell, Jessica L, Trafford, Andrew W
Publicado 2018

The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications

por Eisner, David A., Caldwell, Jessica L., Trafford, Andrew W., Hutchings, David C.
Publicado 2020

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

por Greensmith, David J., Galli, Gina L.J., Trafford, Andrew W., Eisner, David A.
Publicado 2014

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

por Briston, Sarah J., Dibb, Katharine M., Solaro, R. John, Eisner, David A., Trafford, Andrew W.
Publicado 2014

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P(3) and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

por Bennett, Hayley J., Davenport, John Bernard, Collins, Richard F., Trafford, Andrew W., Pinali, Christian, Kitmitto, Ashraf
Publicado 2013

Localised micro-mechanical stiffening in the ageing aorta

por Graham, Helen K., Akhtar, Riaz, Kridiotis, Constantinos, Derby, Brian, Kundu, Tribikram, Trafford, Andrew W., Sherratt, Michael J.
Publicado 2011

Serial block face scanning electron microscopy reveals region-dependent remodelling of transverse tubules post-myocardial infarction

por Perera, Tharushi, Pius, Charlene, Niort, Barbara, Radcliffe, Emma J., Dibb, Katharine M., Trafford, Andrew W., Pinali, Christian
Publicado 2022

Increased Ca buffering underpins remodelling of Ca(2+) handling in old sheep atrial myocytes

por Clarke, Jessica D., Caldwell, Jessica L., Pearman, Charles M., Eisner, David A., Trafford, Andrew W., Dibb, Katharine M.
Publicado 2017

Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis

por Denham, Nathan C., Pearman, Charles M., Madders, George W. P., Smith, Charlotte E. R., Trafford, Andrew W., Dibb, Katharine M.
Publicado 2021

PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca(2+) Content

por Hutchings, David C., Pearman, Charles M., Madders, George W.P., Woods, Lori S., Eisner, David A., Dibb, Katharine M., Trafford, Andrew W.
Publicado 2021

Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

por Denham, Nathan C., Pearman, Charles M., Caldwell, Jessica L., Madders, George W. P., Eisner, David A., Trafford, Andrew W., Dibb, Katharine M.
Publicado 2018

Chronic vagal nerve stimulation has no effect on tachycardia‐induced heart failure progression or excitation–contraction coupling

por Radcliffe, Emma J., Pearman, Charles M., Watkins, Amy, Lawless, Michael, Kirkwood, Graeme J., Saxton, Sophie N., Eisner, David A., Trafford, Andrew W.
Publicado 2020

Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality

por Anderson, Simon G, Hutchings, David C, Woodward, Mark, Rahimi, Kazem, Rutter, Martin K, Kirby, Mike, Hackett, Geoff, Trafford, Andrew W, Heald, Adrian H
Publicado 2016

Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model

por Horn, Margaux A., Bode, Elizabeth F., Borland, Samantha J., Kirkwood, Graeme J., Briston, Sarah J., Richards, Mark A., Dibb, Katharine M., Trafford, Andrew W.
Publicado 2016

Interaction of background Ca(2+) influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca(2+) waves in sheep heart

por Hutchings, David C., Madders, George W. P., Niort, Barbara C., Bode, Elizabeth F., Waddell, Caitlin A., Woods, Lori S., Dibb, Katharine M., Eisner, David A., Trafford, Andrew W.
Publicado 2022

Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep

por Pearman, Charles M., Madders, George W.P., Radcliffe, Emma J., Kirkwood, Graeme J., Lawless, Michael, Watkins, Amy, Smith, Charlotte E.R., Trafford, Andrew W., Eisner, David A., Dibb, Katharine M.
Publicado 2018

Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner

por Smith, Kerri L. M., Swiderska, Agnieszka, Lock, Mitchell C., Graham, Lucia, Iswari, Wulan, Choudhary, Tashi, Thomas, Donna, Kowash, Hager M., Desforges, Michelle, Cottrell, Elizabeth C., Trafford, Andrew W., Giussani, Dino A., Galli, Gina L. J.
Publicado 2022