Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

por Tran, Hue N.T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina, Schroeder, Christina I.
Publicado 2022

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

por Kremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga, Muttenthaler, Markus
Publicado 2022

Improving the Gastrointestinal Stability of Linaclotide

por Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina, Muttenthaler, Markus
Publicado 2021

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site

por Gulsevin, Alican, Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina, Meiler, Jens
Publicado 2021

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor

por McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina, Schroeder, Christina I.
Publicado 2020

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na(V)1.7

por McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina, Schroeder, Christina I.
Publicado 2022

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite

por Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I., Muttenthaler, Markus
Publicado 2021

Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function

por Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N., Zhao, Jing, Stehbens, Samantha J., Mobli, Mehdi, Leffler, Andreas, Jiang, Daohua, Cox, James J., Waxman, Stephen G., Dib-Hajj, Sulayman D., Neely, G. Gregory, Durek, Thomas, Vetter, Irina
Publicado 2023